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| Product Type | Recombinant Protein |
| Uniprot No. | P08069 |
| Species | Homo sapiens (Human) |
| Gene Names | IGF1R |
| Protein Names | Recommended name: Insulin-like growth factor 1 receptor EC= 2.7.10.1 Alternative name(s): Insulin-like growth factor I receptor Short name= IGF-I receptor CD_antigen= CD221 Cleaved into the following 2 chains: 1. Insulin-l |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Function | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways |
| Involvement in disease | Insulin-like growth factor 1 resistance (IGF1RES) |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein |
| Protein Families | Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily |
| Tissue Specificity | Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the |
| Database Links |
HGNC: 5465 OMIM: 147370 KEGG: hsa:3480 STRING: 9606.ENSP00000268035 UniGene: Hs.643120 |
| Pathway |
HIF-1 signaling pathway
MAPK signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Focal adhesion Adherens junction Autophagy Ras signaling pathway Signaling pathways regulating pluripotency of stem cells AMPK signaling FoxO signaling pathway Rap1 signaling pathway Endocytosis |
| Product Name | Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial,E.coli |
| Code | CSB-EP011087HU |
| Size | Pls inquiry other sizes |
| Source | E.coli |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-SUMO-tagged and C-terminal Myc-tagged N-terminal His-B2M-tagged and C-terminal Myc-tagged N-terminal His-GST-tagged and C-terminal Myc-tagged N-terminal His-tagged N-terminal His-SUMO-tagged N-terminal His-B2M-tagged N-terminal His-GST-tagged N-terminal GST-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial,Baculovirus |
| Code | CSB-BP011087HU |
| Size | Pls inquiry other sizes |
| Source | Baculovirus |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
We currently have a catalog number CSB-EP011087HU human IGF1R. Can you please tell me the difference between CSB-EP011087HU and CSB-EP011087HUa0?
IGF1R Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA011087GA01HU | IGF1R Antibody | Human,Mouse,Rat | ELISA,WB,IP |
| CSB-PA597654 | Phospho-IGF1R (Tyr1165/Tyr1166) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA067618 | IGF1R (Ab-1161) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA142373 | IGF1R (Ab-1165/1166) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA120059 | Phospho-IGF1R (Tyr1161) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA945418 | Phospho-IGF1R (Tyr1346) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA942675 | IGF1R (Ab-1346) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA443662 | IGF1R (Ab-1280) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA449888 | Phospho-IGF1R (Tyr1280) Antibody | Human | ELISA,WB |
| CSB-PA277594 | IGF1R (Ab-1346) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000549 | Phospho-IGF1R (Y1165/Y1166) Antibody | Human,Mouse,Rat,Monkey | WB,ELISA |
| CSB-PA009487 | Phospho-IGF1R (Y1346) Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA009489 | IGF1R Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA009490 | IGF1R Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA08395B0Rb | IGF1R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08395C0Rb | IGF1R Antibody, FITC conjugated | Human | ELISA |
| CSB-PA08395D0Rb | IGF1R Antibody, Biotin conjugated | Human | ELISA |
IGF1R Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA009488 | IGF1R Antibody | Human,Mouse,Rat | WB,ELISA |
IGF1R Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA08395A0Rb | IGF1R Antibody | Human | ELISA, IF |
IGF1R Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP011087HU | Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial | E.coli |
| CSB-YP011087HU | Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial | Yeast |
| CSB-CF011087HU | Recombinant Human Insulin-like growth factor 1 receptor(IGF1R) | in vitro E.coli expression system |
| CSB-EP011087HUa0 | Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial | E.coli |
| CSB-MP011087HU | Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial | Mammalian cell |
IGF1R ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E13766h | Human insulin-like growth factors 1 receptor,IGF-1R ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
Recombinant Mouse Homeobox protein Nkx-3.2(Nkx3-2)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Mouse Interleukin-2 receptor subunit beta(Il2rb),partial
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Dog Annexin A4(ANXA4)
Express system: E.coli
Species: Canis lupus familiaris (Dog) (Canis familiaris)
Recombinant Human Phospholipid transfer protein(PLTP)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Sulfotransferase 1A1(Sult1a1)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Heat shock protein HSP 90-beta(HSP90AB1)
Express system: E.coli
Species: Homo sapiens (Human)
