Recombinant Human Integrin alpha-1 (ITGA1), partial

1. It was found that the levels of integrin alpha1 and VE-cadherin mRNA increased during co-culturing of activated endothelium cells with mesenchymal stromal cells. PMID: 29504106
2. Results suggest that genetic variants in ITGA1 may be involved in the etiology of attention-deficit/hyperactivity disorder and the single-nucleotide polymorphisms -set based analysis is a promising strategy for the detection of underlying genetic risk factors. PMID: 28809852
3. favors adhesive over migratory fibroblast phenotype PMID: 27294728
4. Data suggest that the residue volume at phenylalanine (Phe) in alpha1-helix is critical for alpha(L)/beta(2) integrin (CD49a/CD18) activation and binding with soluble/immobilized ICAM1 (intercellular cell adhesion molecule 1). PMID: 29079572
5. Studies suggest there are two nonoverlapping NK cell populations that are potentially liver resident in humans: CD49a+ NK cells and Eomes hi. PMID: 28318877
6. ANGPTL1 inhibited angiogenesis by interacting with integrin alpha1beta1 receptor to suppress the downstreamJAK2-STAT3 signaling pathway. PMID: 28904065
7. A range of affinities from almost no interaction to the relatively high avidity that characterizes alphaIIbbeta3 is seen between various alpha subunits and beta1 transmembrane and cytosolic domains. PMID: 27929375
8. Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10, Wnt5a, alpha1 integrin, and matrix metalloproteinase-3 in GS/BMP-4-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage. PMID: 27639333
9. a comparative study between the wild type integrin alpha1 I and a gain-of-function E317A mutant. NMR HDX results suggest a relationship between regions exhibiting a reduced local stability in the unbound I domain and those that undergo significant conformational changes upon binding. PMID: 27342747
10. MYC is a key regulating factor for the control of ITGA1 expression in colorectal cancer. PMID: 26096932
11. Data indicate that CD49a(+) NK cells retain their phenotype after expansion in long-term in vitro cultures. PMID: 25672754
12. Integrin alpha1 and beta4 are downregulated, following Dendrofalconerol A treatment, in H460 cells. PMID: 25550552
13. miR-101:DNMT-3B interaction modulates integrin alpha-1 epigenetically. PMID: 24018042
14. 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields. PMID: 23819010
15. CD49a promoted Con A-induced hepatitis through enhancing inflammatory cytokine production (IFN-gamma and IL-17A) by CD4(+) T and invariant natural killer T cells. PMID: 24164540
16. ITGA1 gene SNPs rs1862610, rs24321 43, and rs2447867 and the ITGA1 haplotype block that includes SNPs rs1862610 and rs2432143 were significantly associated with gastric cancer. PMID: 24124332
17. small angle x-ray scattering data suggest that at low collagen peptide concentrations the complex exists in equilibrium between a 1:1 and 2:1 alpha1I-peptide complex. PMID: 24187131
18. CagL is a versatile surface protein equipped with at least two motifs to promote binding to integrins, thereby causing aberrant signaling within host cells and facilitating translocation of CagA into host cells. PMID: 22919661
19. Pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha strongly promotes pericyte proliferation and migration, and concomitantly induces a switch in pericyte integrins, from alpha1 to alpha2 integrin. PMID: 23448258
20. Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation. PMID: 23284937
21. Collagen receptors alpha(1)beta(1) and alpha(2)beta(1) integrins are involved in transmigration of peripheral blood eosinophils, but not mononuclear cells through human microvascular endothelial cells monolayer PMID: 23070086
22. Dynamic structural changes are observed upon collagen and metal ion binding to the integrin alpha1 I domain. PMID: 22847004
23. study characterized the collagen binding properties of an activated variant of the alpha1I domain, harboring a gain-of-function mutation E317A; the activated alpha(1)I domain represents a novel conformation of the alphaI domain, mimicking the structural state where the Arg(287)-Glu(317) ion pair has just broken during the integrin activation PMID: 22030389
24. we have identified a new locus candidate, ITGA1, influencing both fasting glucose and BMD, that may begin to explain the genetic contribution to the epidemiological observations linking type 2 diabetes and osteoporosis PMID: 22698912
25. study identified integrin alpha1/beta1 and alpha2/beta1 heterodimer as a new candidate IgA1 receptor in human mesangial cells PMID: 22298882
26. There was no evidence for differences in integrin alpha1, alpha4, beta1 and beta3 protein levels between the follicular and mid-luteal staged samples. PMID: 22002573
27. the C-linker has a role as a spring-like element that allows relaxation of the alphaI domain in the resting state and controlled tension of the alphaI domain during activation, exerted by the beta chain PMID: 21965670
28. alpha(1)beta(1) integrin is of importance not only for the differentiation of mesenchymal cells into myofibroblasts but also for the neovascularization and connective tissue organization PMID: 19397781
29. Integrin alpha2beta1 might play a more crucial role in maintaining the mechanical creep properties of the collagen matrix than does integrin alpha1beta1. PMID: 21647271
30. Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing PMID: 21521694
31. Prostate tissue-derived CD133+ cells exhibited a moderate level of expression of alpha1 integrin PMID: 20531279
32. Androgens increased INT alpha1 and alpha2 subunits in tubuloepithelial cells and in healthy labial salivary glands. PMID: 20436081
33. Results show that plumieribetin, a fish lectin from the scorpionfish (Scorpaena plumieri), inhibits alpha1beta1 integrin binding to basement membrane collagen IV. PMID: 19850917
34. results suggest that the inadequate trophoblastic invasion, induced by antiphospholipid antibodies, can be the result of decreased alpha1 integrin and VE-cadherin and increased alpha5 integrin and E-cadherin expression in the trophoblast PMID: 11937138
35. role of VLA1 in migration of multiple sclerosis derived antigen-reactive T-cell migration PMID: 12078857
36. determination of crystal structure in complex with an antibody Fab fragment PMID: 12662928
37. endometrial integrin alpha1 and alpha4 expression is more consistently present in the early luteal phase in stimulated cycles than in natural cycles PMID: 12694973
38. VEGF-A induced alpha1 & alpha2 integrins, promoting lymphatic endothelial tube formation & haptotactic migration. Lineage-specific integrin receptor expression contribute to the distinct dynamics of wound-associated angiogenesis & lymphangiogenesis. PMID: 15132990
39. alpha(1)beta(1) and Col-IV contribute to beta-cell functions known to be important for islet morphogenesis and glucose homeostasis PMID: 15485856
40. Enhanced expression of Integrin alpha1 is associated with liver metastases from gastrointestinal tumours PMID: 15679046
41. analysis of binding between collagen type III and integrins alpha1beta1 and alpha2beta1 PMID: 16043429
42. No statistical difference was observed on the expression of alpha1 integrin subunit expression in endometrium in tubal phimosis or hydrosalpinx PMID: 16412752
43. identified integrin alpha1 as a protein tyrosine phosphatase type IVA-interacting protein for the first time, and verified this physical association with pull-down and co-immunoprecipitation assays PMID: 16472776
44. alpha1beta1 integrin is a type IV collagen receptor in pancreatic cancer cells PMID: 17312461
45. results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment PMID: 17603494
46. thrombopoietin-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1, but not PELO or ITGA2. PMID: 17669516
47. A significant subset of VLA-1-positive effector T cells from rheumatoid arthritis patients persists in vivo and in vitro during monoclonal antibody therapy and contributes to residual and recurring inflammation. PMID: 17891451
48. are suggestive of the association of ITGA1 with osteoporosis and related risk in postmenopausal women PMID: 17931993
49. Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion. PMID: 17982677
50. Group B streptococci ACP binds alpha(1)beta(1)-integrin via the D1 domain that promotes GBS internalization within epithelial cells. PMID: 18048918

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HGNC: 6134

OMIM: 192968

KEGG: hsa:3672

STRING: 9606.ENSP00000282588

UniGene: Hs.644352