Recombinant Human Interferon gamma receptor 1(IFNGR1), Escherichia Coli

Unavailable
Code CSB-EP011051HU
Product Type Recombinant Protein
Size Pls inquiry other sizes
Uniprot No. P15260
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Purity >85% (SDS-PAGE)
Sequence EMG TADLGPSSVP TPTNVTIESY NMNPIVYWEY QIMPQVPVFT VEVKNYGVKN SEWIDACINI SHHYCNISDH VGDPSNSLWV RVKARVGQKE SAYAKSEEFA VCRDGKIGPP KLDIRKEEKQ IMIDIFHPSV FVNGDEQEVD YDPETTCYIR VYNVYVRMNG SEIQYKILTQ KEDDCDEIQC QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN SSIKG
Source E.coli
Gene Names IFNGR1
Protein Names Recommended name: Interferon gamma receptor 1 Short name= IFN-gamma receptor 1 Short name= IFN-gamma-R1 Alternative name(s): CDw119 CD_antigen= CD119
Expression Region 18-245
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Product Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
If we fail in developing the specified tag, we will send other tag type directly without negotiation.
Protein Description Extracellular domain
Target Details This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
HGNC 5439
RGD 620570
MGI 107655
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Function Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG)
Involvement in disease Immunodeficiency 27A (IMD27A)
Subcellular location Cell membrane, Single-pass type I membrane protein
Pathway HIF-1 signaling pathway
Jak-STAT signaling pathway
Necroptosis
Natural killer cell mediated cytotoxicity
Osteoclast differentiation
Th1 and Th2 cell differentiation
Th17 cell differentiation

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