Recombinant Human Interferon gamma receptor 2(IFNGR2), Escherichia Coli

Unavailable
Code CSB-EP011052HU
Product Type Recombinant Protein
Size Pls inquiry other sizes
Uniprot No. P38484
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Purity >85% (SDS-PAGE)
Sequence SQL PAPQHPKIRL YNAEQVLSWE PVALSNSTRP VVYQVQFKYT DSKWFTADIM SIGVNCTQIT ATECDFTAAS PSAGFPMDFN VTLRLRAELG ALHSAWVTMP WFQHYRNVTV GPPENIEVTP GEGSLIIRFS SPFDIADTST AFFCYYVHYW EKGGIQQVKG PFRSNSISLD NLKPSRVYCL QVQAQLLWNK SNIFRVGHLS NISCYETMAD ASTELQQ
Source E.coli
Gene Names IFNGR2
Protein Names Recommended name: Interferon gamma receptor 2 Short name= IFN-gamma receptor 2 Short name= IFN-gamma-R2 Alternative name(s): Interferon gamma receptor accessory factor 1 Short name= AF-1 Interferon gamma transducer 1
Expression Region 28-247
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Product Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
If we fail in developing the specified tag, we will send other tag type directly without negotiation.
Protein Description Extracellular domain
Target Details This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
HGNC 5440
RGD 1307532
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Function Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG)
Involvement in disease Immunodeficiency 28 (IMD28)
Subcellular location Cell membrane, Single-pass type I membrane protein, Cytoplasmic vesicle membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Endoplasmic reticulum membrane, Single-pass type I membrane protein, Cytoplasm
Pathway HIF-1 signaling pathway
Jak-STAT signaling pathway
Necroptosis
Natural killer cell mediated cytotoxicity
Osteoclast differentiation
Th1 and Th2 cell differentiation
Th17 cell differentiation

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