Recombinant Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), partial

1. The allelic diversity of the KIR2DL4 receptor locus showed no significant association with leukemia among ethnic Hans from southern China. PMID: 29419875
2. Data show that most of the Langerhans cell histiocytosis (LCH)cases were positive for KIR2DL4, suggesting that KIR2DL4 may serve as a marker for LCH diagnosis. PMID: 28445138
3. Data show the alignment of different KIR2DL4 receptor alleles with ADOMA. PMID: 27491653
4. Serum levels of soluble HLA-G were similar in CMV- and CMV+ subjects but levels in culture supernatants were significantly higher in cells from CMV+ than from CMV- subjects stimulated with CMV antigens. The HLA-G ligand KIR2DL4 was mainly expressed on NK cells and CD56+ T cells with no differences between CMV+ and CMV- subjects. PMID: 28817184
5. a woman's heterozygosity in HLA-G and LILRB1 might be an advantage for a success of reproduction, but the partner's heterozygosity in 9A/10A KIR2DL4 alleles might not PMID: 26973020
6. Decreased level of KIR2DL4 rather than its single nucleotide polymorphism is correlated with the susceptibility of pre-eclampsia PMID: 26823774
7. the KIR2DL4 on human mast cells facilitates HLA-G-expressing cancer invasion and the subsequent metastasis. PMID: 25735953
8. Among 438 Polish people, a weak difference was seen between males and females in 9769 C/A genotypes and alleles. Fertile women had a high frequency of homozygosity for the defective 9A variant, so KIR2DL4 is not absolutely necessary for reproduction. PMID: 25818657
9. The 9620 9A/10A (rs11410751) polymorphism in exon 7 did not influence the risk of NSCLC. PMID: 25855135
10. Results show that HLA-E and KIR2DL4 demonstrate evidence of positive selection between human, chimpanzee and gorilla suggesting a main role for immunological adaptations linked to embryo deep invasion of the maternal endometrium during pregnancy. PMID: 25451741
11. The unique functional properties of KIR2DL4 may be mediated by self-association of the receptor. PMID: 25759384
12. Genetic polymorphism of KIR2DL4, a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma. PMID: 24033084
13. Abs to KIR2DL4 and HLA-G did not block NK cell IFN-gamma production. PMID: 24337374
14. KIR2DL4 was found to directly interact with HS/heparin, and the D0 domain of KIR2DL4 was essential for this interaction. PMID: 24127555
15. Beta Microglobulin-free HLA-G activates NK cells via engagement of KIR2DL4 receptors. PMID: 23228393
16. Sustained activation through CD158d induced morphological changes in NK cell shape and size, and survival in the absence of cell-cycle entry, all hallmarks of senescence. PMID: 23184984
17. Significant differences in the frequency of KIR genes were found between the two populations despite being separated by only 300 km PMID: 22320834
18. Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions. PMID: 22467658
19. KIR2DL4 gene may not be essential for fertility, as shown in a fertile Caucasian woman missing KIR2DL4 [case report] PMID: 21623736
20. Decreased KIR2DL4 expression in placenta may participate in the pathogenesis of pre-eclampsia. PMID: 19134329
21. The frequencies of alleles of killer cell immunoglobulin-like receptor genes, KIR3DL3 and KIR3DL2, and the carrier frequency of KIR2DL4 alleles have been determined from a population of African Americans by DNA sequencing of the coding regions. PMID: 21607693
22. The expression of KIR2DL4 on NK cells in acute rejection group was statistically lower than that in stable kidney function group after renal transplantation. PMID: 21092455
23. By promoting polyubiquitylation and degradation, E3 ubiquitin ligase Triad3A is identified as an interaction partner for the KIR2DL4 cytoplasmic domain. PMID: 21270397
24. The sequential requirement for DNA-dependent protein kinase, Akt, and NF-kappaB in signaling by CD158d delineates a previously uncharacterized endosomal signaling pathway for a proinflammatory response in natural killer cells. PMID: 20179272
25. KIR2DL4 itself is not associated with preeclampsia, but it may modulate the effect of HLA-G*0106 on risk for preeclampsia. PMID: 19700612
26. The single tyrosine-based inhibitory motif (ITIM)in the cytoplasmic domain of KIR2DL4 efficiently inhibits natural cytotoxicity responses and recruits SHP-2 protein tyrosine phosphatase (but not SHP-1) to the 2DL4 cytoplasmic domain in NK cells. PMID: 11994457
27. KIR2DL4 has the potential for both activating and inhibitory functions. PMID: 12055234
28. NK clones express both 2DL4 alleles and either one or both alleles of the clonally restricted KIR 3DL1 and 3DL2 genes. PMID: 12538663
29. All genotypes seen included genes for KIR2DL4. PMID: 12559621
30. NK cell receptor, KIR2DL4:HLA-G interaction is not essential for human reproduction. PMID: 12616484
31. The promoter for KIR2DL4 is expressed by all natural killer (NK) cell clones and drives reporter gene expression only in NK cells. PMID: 12794136
32. isolated 3 distinct KIR2DL4 allele clones in each individual with multiple copies of KIR3DL/S1; assumption that unequal crossover event occurred between differing KIR haplotypes resulting in the duplication of the 2DL4, 3DS1/3DL1 genes PMID: 12826375
33. KIR2DL4 transmembrane exon genotype influences both levels of membrane expression and activation of cytotoxic function. PMID: 12902476
34. Appropriate engagement of KIR2DL4 can selectively stimulate NK cells to elicit a strong IFN-gamma response, which has the potential to contribute significant biological benefits, but only in individuals capable of expressing this receptor. PMID: 14500636
35. Specific amplification of the D0 & D2 domains permit PCR discrimination of KIR2DL4 alleles & their frequencies in various cell lines and human populations. PMID: 14700593
36. 4.5% of the individuals of a Caucasoid population bear a recombinant allele of KIR3DP1, officially designed KIR3DP1*004, that associates tightly with gene duplications of KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 PMID: 15580659
37. report that ILT2 receptor, ILT3 receptor, ILT4 receptor, and KIR2DL4 receptor expression is up-regulated by HLA-G histocompatibility antigen in antigen-presenting cells, natural killer cells, and T cells PMID: 15670976
38. evidence that FcepsilonRI-gamma (gamma) associates with 2DL4 to promote surface expression and provide signal transducing function. PMID: 15778339
39. an inhibitory element was identified in the KIR2DL4 promoter and an activating element was found in the KIR3DL3 promoter; AML-2 acts as a repressor of expression of both KIR2DL4 and KIR3DL3 in mature NK cells PMID: 15778373
40. KIR2DL4 alleles may explain the high frequency of this variation in the population. PMID: 15853895
41. KIR2DL4 was constitutively internalized into Rab5-positive compartments in NK cells via dynamin-dependent process. Chemokine secretion induced by KIR2DL4 transfection into 293T cells occurred only with recombinant forms of KIR2DL4 trafficked to endosomes. PMID: 16366734
42. New insights are provided into the mechanisms by which genetic polymorphism of the KIR2DL4 gene influences its expression. PMID: 17171757
43. 8 known KIR2DL4 alleles were observed in individuals involved in bone marrow transplantation; 3 new alleles, KIR2DL4*00203, *00502, *0080104, differering from known alleles at the nucleotide but not the protein sequence level were also identified PMID: 17610421
44. Three new alleles of KIR2DL4 have been identified, among those one allele showed alternatively spliced products. PMID: 18082267
45. Signaling pathways are specifically activated by engagement of killer receptor KIR2DL4 transmembrane association with the FcepsilonRI-gamma (FCER1G) receptor in natural killer (NK) cells. PMID: 18292514
46. Human leukocyte antigen-G, a ligand for the natural killer receptor KIR2DL4, is expressed by eutopic endometrium only in the menstrual phase. PMID: 18314122
47. Increased competency of T cells to express KIR2DL4 with aging is conferred by a selective increase in H3-Lys 4 dimethylation and limited DNA demethylation PMID: 18586981
48. Whereas 26% of the study population has a genotype corresponding to a lack of any functional membrane-bound form of the molecule, no association of the KIR2DL4 transmembrane alleles with susceptibility to MS was observed. PMID: 19304328
49. Cross-linking with anti-LILRB1 on CD14(+) macrophages or anti-KIR2DL4 on CD56(+) NK cells resulted in up-regulation of a small subset of mRNAs including those for IL-6, IL-8, and TNFalpha PMID: 19304799
50. Data showed that the CD70, perforin and KIR2DL4 promoters are demethylated in CD4(+)CD28(-) T cells, and that DNA methyltransferase 1 (Dnmt1) and Dnmt3a levels are decreased in this subset. PMID: 19394279

Show More

Hide All

HGNC: 6332

OMIM: 604945

KEGG: hsa:3805

UniGene: Hs.661219