Recombinant Human LRP2-binding protein (LRP2BP)

Code CSB-YP882182HU
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Source Yeast
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Code CSB-EP882182HU
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Source E.coli
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Code CSB-EP882182HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP882182HU
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Source Baculovirus
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Code CSB-MP882182HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
LRP2BP
Uniprot No.
Alternative Names
LRP2BP; KIAA1325; LRP2-binding protein; Megalin-binding protein; MegBP
Species
Homo sapiens (Human)
Expression Region
1-347
Target Protein Sequence
MKLTSEKLPK NPFYASVSQY AAKNQKFFQW KKEKTDYTHA NLVDKALQLL KERILKGDTL AYFLRGQLYF EEGWYEEALE QFEEIKEKDH QATYQLGVMY YDGLGTTLDA EKGVDYMKKI LDSPCPKARH LKFAAAYNLG RAYYEGKGVK RSNEEAERLW LIAADNGNPK ASVKAQSMLG LYYSTKEPKE LEKAFYWHSE ACGNGNLESQ GALGLMYLYG QGIRQDTEAA LQCLREAAER GNVYAQGNLV EYYYKMKFFT KCVAFSKRIA DYDEVHDIPM IAQVTDCLPE FIGRGMAMAS FYHARCLQLG LGITRDETTA KHYYSKACRL NPALADELHS LLIRQRI
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May act as an adapter that regulates LRP2 function.
Gene References into Functions
  1. both in the cytoplasm and nucleus, 4 ankyrin repeats PMID: 15809689
  2. Aberrant shedding of megalin and cubilin may contribute to albuminuria in diabetes and to deficiency states of important vitamins and hormones. PMID: 19366958
  3. A 56-year-old female patient with FOAR syndrome and a novel mutation is reported. PMID: 19577669
Subcellular Location
Cytoplasm. Note=Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.
Database Links

HGNC: 25434

KEGG: hsa:55805

STRING: 9606.ENSP00000332681

UniGene: Hs.558513

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