Recombinant Human Microtubule-associated protein 2 (MAP2), partial

Code CSB-YP013408HU
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Source Yeast
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Code CSB-EP013408HU
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Source E.coli
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Code CSB-EP013408HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP013408HU
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Source Baculovirus
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Code CSB-MP013408HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
MAP2
Uniprot No.
Alternative Names
DKFZp686I2148; MAP 2; MAP dendrite specific; MAP-2; MAP2; MAP2A; MAP2B; MAP2C; Microtubule associated protein 2; Microtubule-associated protein 2; MTAP2_HUMAN
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Gene References into Functions
  1. study suggests that miR-484 and MAP2 can be utilized as predictors for the clinical diagnosis and prognosis of glioma PMID: 29480405
  2. Results highlight the importance of splicing alteration in HD and suggest that MAP2 alteration contributes to dendritic atrophy. PMID: 27098187
  3. The expression of MAP2 and SYP proved most relevant to neurocognitive functioning in HIV-infected patients. PMID: 26637429
  4. In patients with HD, a panel using calretinin and peripherin with or without MAP-2 may be most helpful in identifying transition zones PMID: 26469323
  5. Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells. PMID: 26014048
  6. Study reveals the presence of two selected neuronal markers, MAP-2 and SYP mRNAs and protein expression, in eutopic endometrium and in endometriotic lesions. PMID: 26604067
  7. Findings demonstrate that microtubule-associated protein 2-immunoreactivity loss is closely linked to dendritic spine pathology in schizophrenia. PMID: 25818630
  8. This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. PMID: 25871823
  9. the difference of only two amino acids in tau and MAP2 sequences may determine their different fates in tauopathies PMID: 26134402
  10. MAP2 expression is affected by actomyosin contractility during nanotopography-directed neuronal differentiation of human embryonic stem cells PMID: 25682157
  11. Prolactin significantly increased the gene expression and protein levels of MAP2 in SK-N-SH neuroblastoma cells, while no significant changes were observed in U-87MG glioblastoma cells. PMID: 25629269
  12. SNCG, MAP2, SDF-1 and CXCR4 may play an important role in the carcinogenesis, progression, invasion and metastasis of gastric adenocarcinoma. PMID: 25400739
  13. MAP2 expression in ovarian teratomas does not appear to have a role in predictive the development of anti-NMDAR encephalitis. PMID: 25569473
  14. PP2A/striatin complex modulates microtubule dynamics by regulating MAP2 phosphorylation PMID: 25497017
  15. MAP 2 is a moderately sensitive marker of haemangioblastoma PMID: 24977729
  16. MAP2 may play a significant role in neurotoxicity in the Alzheimer's disease brain despite the absence of MAP2-aggregates. PMID: 24587039
  17. Study suggests that many of the morphological changes detected in children's brainstems regarding distributions of HIF-1alpha and MAP-2 could be due to age differences, but in some regions these distributions are more dependent on the hypoxic conditions PMID: 24780770
  18. Altered MAP2 and tau expression in mesial temporal lobe epilepsy (MTLE) and decreased tau expression in MTLE with psychosis were found. PMID: 24069608
  19. MAP-2 and nestin participate in the regulation of the development of gastric tissues in human embryos. PMID: 22985576
  20. Dysfunction of MAP2/tau family leads to disruption of microtubule structure and impairment of axonal transport, and eventually triggers apoptosis in neurons, which becomes an essential pathway for prion to induce the neuropathology. PMID: 22874672
  21. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn. PMID: 22403409
  22. Data indicate that the decline of MAP2 is a common phenomenon in transmissible spongiform encephalopathies (TSEs), which seems to occur at an early stage of incubation period. PMID: 22272295
  23. Increased MAP2 expression in malignant melanoma cells significantly inhibits tumor cell growth and neoplasm invasiveness, and induces apoptosis and cell cycle arrest. PMID: 20100193
  24. The results of this study confirmed previous published data showing a schizophrenia-associated decrease in MAP2 in area 9 with no change in area 17 and no change in Huntington chorea. PMID: 20092829
  25. Hyperactivation of BRAF-MEK signaling activates MAP2 expression in melanoma cells by two independent mechanisms, promoter demethylation or down-regulation of neuronal transcription repressor HES1. PMID: 19880519
  26. MAP2 expression in astrocytomas is due predominantly to low molecular weight isoforms, evident in astrocytes as well as neurons; focal expression of hmw-MAP2 suggests that neuronal antigens may be expressed, particularly in high grade astrocytomas. PMID: 11922706
  27. role of small cluster of charged residues in controlling filament morphology PMID: 12023276
  28. beta-chains of tubulin and MAP-2 are expressed functionally in SCLC cell lines in association with the development of dendrite-like processes on PC-9 / ECM substrate PMID: 12079519
  29. These results provide strong evidence suggesting that MAP2c and tau stabilize microtubules by binding along individual protofilaments, possibly by bridging the tubulin interfaces. PMID: 12082079
  30. Immunoreactivity of MAP-2 has been demonstrated in most neuroendocrine and neuroectodermal related neoplasms such as small cell carcinoma, large cell neuroendocrine carcinoma, carcinoid tumor of the lung. PMID: 12605092
  31. binding of dehydroepiandrosterone to MAP2C involves specific hydrogen bonds that orient the steroid into the pocket PMID: 12775713
  32. The differential distribution of various epitopes suggests that the presence of the Phospho-Ser(262) epitope of tau either accelerates the transition form pre-tangle to tangle, or appears later than the other epitopes in the process of tangle formation. PMID: 12927759
  33. over-expression of microtubule-associated protein 2 is associated with oral squamous cell carcinoma PMID: 14604896
  34. These data point towards MAP2 as valuable diagnostic tool for pattern recognition and differential diagnosis of low-grade neuroepithelial tumors. PMID: 15146346
  35. Decreased spinophilin but unchanged MAP2 expression provides molecular evidence for a hippocampal dendritic pathology in schizophrenia that preferentially affects the spines PMID: 15465982
  36. determined that Fyn phosphorylated MAP-2c on tyrosine 67 PMID: 15536091
  37. MAP2 is involved in the association of endoplasmic reticulum membranes with microtubules. PMID: 15623521
  38. Independent of one another MAP-2c and Fyn are able to induce process outgrowth and in concert can initiate and enhance process outgrowth in an additive manner. PMID: 16145685
  39. MAP-2 is expressed in the cytoplasm of non-tumorous adenohypophysial cells as well as of various pituitary adenoma types. PMID: 16195780
  40. Tat action on MAP2 stability involved Tat-mediated translocation of the proteasome to the site of microtubule filaments. PMID: 16611822
  41. Notch signaling, which is implicated in melanoma progression, and Hairy and Enhancer of Split (HES1) play a role in MAP2 gene regulation during melanoma progression. PMID: 16916793
  42. Thus, our findings have not only identified a novel role of MAP2 in non-neuronal cells, but also provided the first implication of MAP2 in malignant oral cancer tissues. PMID: 18073143
  43. Data show that the Sudden infant death syndrome group and hypoxic/ischemic group exhibites a general reduction in the number of MAP2 reactive neurons in comparison with the non-hypoxic/ischemic injury group. PMID: 19009302
  44. MAP-2 immunoexpression in gliomatosis cerebri PMID: 19309409
  45. In contrast with the findings of previous studies, our data indicate that MAP-2 is a moderately positive predictor of the progression of superficial spreading melanomas. PMID: 19369632
  46. MAP-2 is a sensitive and specific marker of neuroblastoma, both in the primary tumor and bone marrow biopsy settings. PMID: 19701075

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Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, dendrite.
Database Links

HGNC: 6839

OMIM: 157130

KEGG: hsa:4133

STRING: 9606.ENSP00000353508

UniGene: Hs.368281

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