Recombinant Human Mitogen-activated protein kinase kinase kinase 1 (MAP3K1), partial

1. Through a stratification analysis, 5q11.2/MAP3K1 (rs16886034, rs16886364, rs16886397, rs1017226, rs16886448) and 7q32.3/LINC-PINT (rs4593472) were associated with Luminal A, and 10q26.1/FGFR2 (rs35054928) was associated with Luminal B. PMID: 28408616
2. findings show a robust association between the variant allele of rs832582 (MAP3K1906Val) and decreased VFDs in patients with ARDS and suggest that this variant may predispose individuals to a greater inflammatory response. PMID: 28858533
3. We have revealed significant association of FGFR2 and MAP3K1 polymorphisms with breast cancer. PMID: 29372690
4. Identification of a MAP3K1 variant should prompt an evaluation for disorders of sex development in female siblings of the proband PMID: 28504475
5. Polymorphism of MAP3K1 is associated with breast cancer. PMID: 28178648
6. SNP variants at the MAP3K1/SETD9 gene boundary associate with somatic PIK3CA variants in breast cancers. PMID: 28029147
7. CSN6 positively regulates c-Jun in a MEKK1-dependent manner PMID: 26237449
8. BAALC conferred chemoresistance in acute myeloid leukemia cells by upregulating ATP-binding cassette proteins in an ERK-dependent manner, which can be therapeutically targeted by MEK inhibitor PMID: 26050649
9. MiR-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D and MAP3K1 expression. PMID: 26019450
10. There were 3 specimens with mutations in MAP3K1 (MEKK1), including two truncation mutants, T779fs and T1481fs; T1481fs encoded an unstable and nonfunctional protein when expressed in vitro. PMID: 25899310
11. Results demonstrate that MAP3K1 rs889312 is closely correlated with outcome among diffuse-type gastric cancer in a Chinese population. PMID: 24759887
12. We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival. PMID: 25529635
13. The present meta-analysis suggests that MAPKKK1 rs889312-C allele and rs16886165-G allele might be risk factors for breast cancer, especially in Europeans and Asians. PMID: 24595411
14. MAP3K1 mutations tilt the balance in the sex-determining pathways by downregulating SOX9 and FGF9. PMID: 24135036
15. MAP3K1 protein expression level in breast cancer cells was higher than that in normal mammary gland cells. PMID: 24253898
16. MAP3K1 single nucleotide polymorphism rs889312 was confirmed to be associated with breast cancer risk (P = 0.04, OR 1.15, 95% CI 1.01-1.30). PMID: 23634849
17. FGFR2 and MAP3K1 SNPs have an additive effect on an increased risk of familial breast cancer in a South-American population. PMID: 23225170
18. We also observed that four Single Nucleotide Polymorphisms (SNPs) were associated with severe asthma PMID: 22468730
19. High MEK1 is associated with hepatocellular carcinoma. PMID: 22110214
20. Novel phosphorylation-dependent ubiquitination of tristetraprolin by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1) and tumor necrosis factor receptor-associated factor 2 (TRAF2) PMID: 21921033
21. Apoptosis induced by cytoskeletal disruption requires distinct domains of MEKK1. PMID: 21364884
22. MAP3K1 rs889312 polymorphism is associated with increased risk of breast cancer in BRCA1 mutation carriers PMID: 20809358
23. The upstream molecule of the TRAIL-induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8-dependent manner. PMID: 21152872
24. Data show that MEKK-1 plays an integral role in IL-1beta modulation of Caco-2 TJ barrier function by regulating the activation of the canonical NF-kappaB pathway and the MLCK gene. PMID: 21048223
25. mutations in MAP3K1 that result in 46,XY DSD with partial or complete gonadal dysgenesis implicate this pathway in normal human sex determination PMID: 21129722
26. MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein PMID: 20923779
27. Han11 was required to allow coupling of MEKK1 to DYRK1 and HIPK2. PMID: 20940704
28. These results of MAP3K1, previously reported as an Axin1 inter-actor in c-Jun NH(2)-terminal kinase pathway, is also involved in the canonical Wnt signalling pathway and positively regulates expression of Wnt target genes. PMID: 20128690
29. Modulation of human cytomegalovirus immediate early gene enhancer and promoter activity by MEKK1 is under the control of the NFkappaB/rel sites. PMID: 11746500
30. MEK kinase 1 induces mitochondrial permeability transition leading to apoptosis PMID: 11756439
31. caspase cleavage of MEKK1 is a dynamic regulatory mechanism that alters the subcellular distribution of MEKK1, changing its function to pro-apoptotic signaling PMID: 11782455
32. Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells PMID: 11903060
33. Results suggest that the conserved AR acetylation site contributes to a pathway governing prostate cancer cellular survival, as AR acetylation mutants are defective in MEKK1-induced apoptosis. PMID: 11971970
34. Results show that oncogenic ras provokes premature senescence by sequentially activating the MEK-ERK and MKK3/6-p38 pathways in normal, primary cells. PMID: 11971971
35. the NOx-induced cell proliferation via activation of MEKK1 might contribute to lung tissue damage caused by NOx PMID: 12079429
36. The difference of suppression in pancreatic cancer cells and non-pancreatic cancer cells suggested that the MEKK1 pathway mainly contributes to cell survival in pancreatic cancer cells PMID: 12185592
37. mechanism by which the MEKK1-dependent JNK/SAPK pathway is negatively regulated by PAK through phosphorylation of serine 67 PMID: 12228228
38. Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways PMID: 12456688
39. MEKK1 is activated by GSK3beta PMID: 12584189
40. Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. PMID: 12878610
41. subdomain VIII of MEKK1 is involved not only in binding to, but also in discrimination of, protein substrates PMID: 14500727
42. coexpression of constitutive-active MEKK1 inhibited orphan receptor TR3 transcriptional activity and TR3-induced proliferation in lung cancer cells PMID: 14612408
43. The G(i)-Ras-MEKK1 signaling pathway mediates lysophosphatidic acid-stimulated ovarian cancer cell migration by facilitating focal adhesion kinase redistribution to focal contacts. PMID: 15205333
44. glutathione s-transferaase Mu suppresses MEKK1-mediated apoptosis and functions as a negative regulator of MEKK1. PMID: 15299005
45. MEKK1 plays a key role in Bcr-Abl-induced STAT3 activation and in ES cells' capacity for LIF-independent self-renewal and may thus be involved in Bcr-Abl-mediated leukemogenesis in stem cells PMID: 16044153
46. Galpha13-induced VASP phosphorylation that involves activation of RhoA and MEKK1, phosphorylation and degradation of IkappaB, release of PKA catalytic subunit from the complex with IkappaB and NF-kappaB, and subsequent phosphorylation of VASP PMID: 16046415
47. Induction of Nur77 nuclear export by MEKK1 required a prolonged MEKK1 activation and was attenuated by Akt activation. Expression of constitutively active Akt prevented MEKK1-induced Nur77 nuclear export. PMID: 16434970
48. Pge2 abolished the MEKK1-induced MMP-1 promoter luciferase activity. PMID: 16714289
49. MEKK1 transmits wound signals, leading to the transcriptional activation of genes involved in Extracellular Matrix homeostasis, epithelial cell migration, and wound reepithelialization. PMID: 16760432
50. Caspase-3 and the p38alpha MAP kinase were activated during TIMP-1-induced UT-7 cells erythroid differentiation. PMID: 17301822

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HGNC: 6848

OMIM: 600982

KEGG: hsa:4214

STRING: 9606.ENSP00000382423

UniGene: Hs.653654