Recombinant Human N-glycosylase/DNA lyase(OGG1)

Code CSB-YP016313HU
Product Type Recombinant Protein
Size US$2474
Uniprot No. O15527
Relevance DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias 8-oxoguanine DNA glycosylase (EC:3.2.2.-) DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18) Short name: AP lyase
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
Research Area Cancer
Source Yeast
Gene Names OGG1
Protein Names Recommended name: N-glycosylase/DNA lyase Including the following 2 domains: 8-oxoguanine DNA glycosylase EC= 3.2.2.- DNA-(apurinic or apyrimidinic site) lyase Short name= AP lyase EC= 4.2.99.18
Expression Region 1-345aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 40.8kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Involvement in disease Renal cell carcinoma (RCC)
Subcellular Location Nucleus, nucleoplasm, Nucleus speckle, Nucleus matrix
Protein Families Type-1 OGG1 family
Tissue Specificity Ubiquitous.
Database Links

HGNC: 8125

OMIM: 144700

KEGG: hsa:4968

UniGene: Hs.380271

Pathway DNA repair pathway

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