Recombinant Human Netrin receptor DCC (DCC), partial

Code CSB-YP006536HU
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Source Yeast
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Code CSB-EP006536HU
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Source E.coli
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Code CSB-EP006536HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP006536HU
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Source Baculovirus
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Code CSB-MP006536HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
DCC
Uniprot No.
Alternative Names
Colorectal cancer related chromosome sequence 18; Colorectal cancer suppressor; CRC 18; CRC18; CRCR 1; CRCR1; DCC; DCC_HUMAN; Deleted in colorectal cancer protein; Deleted in colorectal carcinoma ; Immunoglobulin superfamily DCC subclass member 1; Netrin receptor DCC; Tumor suppressor protein DCC
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Gene References into Functions
  1. Based on the variable expressivity and incomplete penetrance present in heterozygous carriers of a DCC variant, classification and clinical interpretation of missense variants is challenging in the absence of evidence of pathogenicity originated from functional studies PMID: 29366874
  2. Study results indicate that DCC controls corticospinal tract midline crossing in both humans and mice, and that this process is non cell-autonomous in mice. PMID: 28341853
  3. rs2229080 and rs7504990 polymorphisms in DCC might be related with breast cancer susceptibility in Chinese women. PMID: 27127179
  4. Somatic DCC mutations are associated with metastatic NUT midline carcinoma. PMID: 28967088
  5. Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK. PMID: 28701345
  6. Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin. PMID: 27716118
  7. Identified DCC mutations in four families. PMID: 28250454
  8. DCC polymorphism maybe responsible for successful treatment of patients with hydrochlorothiazide . diagnosed with hypertension. PMID: 27381900
  9. Deleted in colorectal cancer (DCC) confers susceptibility to depression-like behaviors in humans and mice and Is regulated by miR-218. By regulating DCC, miR-218 may be a switch of susceptibility versus resilience to stress-related disorders. PMID: 27773352
  10. DCC/18q and ERBB2/17q gene copy number variations are associated with disease-free survival in microsatellite stable colon cancer PMID: 28006840
  11. Allelic and genotypic frequencies of the DCC polymorphism rs2229080 were nominally associated with schizophrenia. PMID: 27055860
  12. Results of APC and DCC LOH, KRAS and microsatellite instability indicate our colorectal cancer cases were typical of sporadic cancers following the 'chromosomal instability' pathway. PMID: 26970738
  13. The study identified DCC as a differentially expressed gene and clustered meningiomas into DCC low expression (3 grade I and 3 grade II tumors), DCC medium expression (2 grade I and 1 grade II tumors), and DCC high expression (5 grade I tumors) groups. PMID: 27096627
  14. Data suggest that, in response to netrin-1/netrin receptor (DCC) signaling, p120RasGAP is recruited to growth cones and supports axon outgrowth; p120RasGAP Src homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth. PMID: 26710849
  15. By analyzing multiple myeloma-derived cell lines and patient-derived primary CD138-positive plasma cells ... authors show for the first time that transcriptional dysregulation of DCC is involved in the progression of plasma cell malignancy. PMID: 26390996
  16. the transfected DCC gene can suppress cell proliferation and lead to downregulation of CEA expression in SW1116 cells. PMID: 26345965
  17. Signaling mechanism of the netrin-1 receptor DCC in axon guidance PMID: 25881791
  18. NTN1-DCC pathway contains targets of FDA-approved drugs and may offer promise for guiding applied clinical research on preventive and therapeutic interventions for AMD PMID: 25950802
  19. DCC mutation correlated with fractionated mirroring in individuals with Congenital mirror movements PMID: 25813273
  20. Data show that silencing ezrin-radixin-moesin (ERM) protein expression ablates deleted in colorectal carcinoma protein (DCC)-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation. PMID: 25575591
  21. Three novel truncating mutations of DCC are associated with congenital mirror movements. PMID: 24808016
  22. EDNRB and/or DCC methylation in salivary rinses compares well to examination by an expert clinician in CRC of oral lesions. PMID: 23637120
  23. genetic variations in DCC rs714 (A>G) modulate risk of esophageal and gastric cancers in a high-risk Kashmir population. PMID: 23765761
  24. Ethnic Malays is genetically susceptible to H. pylori infection and is possibly mediated through a genetic variation in the DCC gene. PMID: 22829558
  25. results suggested that cohypermethylation of p14 in combination with DCC and/or CADM1 may be an independent prognostic factor for recurrence in patients with stage I ESCC PMID: 23310950
  26. Netrin-1 and DCC are increased in diseased lumbar intervertebral discs and may play a role in the process of neurovascular growth. PMID: 22588384
  27. This study re-affirms the role of plausible tumor suppressor DCC variants, in gallbladder carcinogenesis and the risk haplotype may be explored as a useful marker for gallbladder cancer susceptibility. PMID: 23353777
  28. The results of this study suggested that DCC as a promising novel candidate gene that may contribute to the genetic basis behind individual differences in susceptibility to schizophrenia. PMID: 22418395
  29. SNP rs7504990 in the DCC showed genome-wide significant association with gallbladder cancer susceptibility. PMID: 22318345
  30. An unexpected binding mode of the DCC peptide to the subdomain C groove of the FERM domain, which is distinct from previously reported beta-beta associations found in radixin-adhesion molecule complexes. PMID: 21642953
  31. Lost expression of DCC gene is associated with ovarian cancer. PMID: 20054719
  32. study reports a novel DCC gene mutation responsible for congenital isolated persistent mirror movements in an Italian family and provide evidence that this entity is genetically heterogeneous PMID: 21242494
  33. our findings might indicate also an important role for DCC and netrin-1 in human foetal central nervous system development PMID: 20609112
  34. study found that individuals affected with congenital mirror movements carried protein-truncating mutations in DCC; mutant DCC protein revealed a defect in netrin-1 binding; DCC has an important role in lateralization of the nervous system PMID: 20431009
  35. DCC methylation was observed in the course of gastric carcinogenesis and disappeared in advanced gastric carcinoma. PMID: 20150623
  36. DCC receptor is localized to syncytiotrophoblasts and invasive extravillous cytotrophoblasts during the first trimester and at term. PMID: 19826074
  37. Altered expression of DCC protein is detectable in gastric carcinomas, an event that may have a role in the development of the disease. PMID: 11518545
  38. The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. PMID: 11817894
  39. Loss of dcc gene expression is associated with acute myelogenous leukemia PMID: 12060632
  40. loss of DCC expression occurs in some colon adenomas, but is insufficient to drive the adenoma to carcinoma progression. PMID: 12432238
  41. data suggest that the codon 201 polymorphism of the DCC gene was a target of LOH, and predicted prognosis in colorectal cancer patients PMID: 12787729
  42. DCC binds to netrin, which regulates its interactions with heparin PMID: 12810718
  43. Prognostic significance of the DCC gene protein expression in high-risk resected gastric carcinoma PMID: 12901278
  44. Deletions in this gene are found in colorectal and gastric cancers PMID: 12901294
  45. Multiple aberrations involving the DCC locus may play a role in the progression of nephroblastomas, and hence confer a poorer prognosis. PMID: 14631365
  46. DCC/netrin-1 signaling may commit cells to the transition of endometrial gland architecture or function from a proliferating to a secretory phase. PMID: 15491747
  47. Binding of netrin-1 to its receptors inhibits tumour suppressor p53-dependent apoptosis (review) PMID: 15573119
  48. DCC binds netrin through the fourth fibronectin type III domain. PMID: 15574733
  49. DCC expression appears not to be predictive in poor survival outcome in patients with stage II or III colorectal cancer. PMID: 15722793
  50. DCC in both commissural neurons and immortalized cells, is partially associated with cholesterol- and sphingolipid-enriched membrane domains named lipid rafts. PMID: 15811950

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Involvement in disease
Mirror movements 1 (MRMV1); Gaze palsy, familial horizontal, with progressive scoliosis, 2 (HGPPS2)
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Immunoglobulin superfamily, DCC family
Tissue Specificity
Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
Database Links

HGNC: 2701

OMIM: 120470

KEGG: hsa:1630

STRING: 9606.ENSP00000389140

UniGene: Hs.162025

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