Recombinant Human Oxidized low-density lipoprotein receptor 1(OLR1),partial

Code CSB-YP016331HU
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Source Yeast
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Code CSB-EP016331HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP016331HU
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Source Baculovirus
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Code CSB-MP016331HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names OLR1
Uniprot No. P78380
Alternative Names C-type lectin domain family 8 member A; CLEC8A; hLOX 1; hLOX-1; Lectin like oxidized LDL receptor 1; Lectin like oxLDL receptor 1; Lectin type oxidized LDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; low density lipoprotein oxidized, receptor 1; LOX-1; LOXIN; Olr1; OLR1_HUMAN; Ox LDL receptor 1; Ox-LDL receptor 1; Oxidised low density lipoprotein (lectin like) receptor 1; Oxidized low density lipoprotein receptor 1; Oxidized low density lipoprotein receptor 1 soluble form; Oxidized low-density lipoprotein receptor 1; OxLDL receptor 1 ; SCARE1; Scavenger receptor class E, member 1; SLOX1; soluble form; SR-EI
Species Homo sapiens (Human)
Protein Length Extracellular domain
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Gene References into Functions
  1. Study showed that a high expression of LOX-1 was associated with poor prognosis in gastric cancer (GC) patients and TNM stage. LOX-1 was found to promote migration, invasion and epithelial-mesenchymal transition (EMT) of GC cells through activating PI3K/Akt/GSK3beta pathway. PMID: 28345638
  2. LOX-1(+) CD15(+) polymorphonuclear myeloid-derived suppressor cells were elevated in hepatocellular carcinoma patients and suppressed T cell proliferation through ROS/Arg I pathway induced by ER stress. PMID: 29211299
  3. High LOX-1 ligand activity as a risk factor for ischemic stroke. PMID: 28442661
  4. The analysis also revealed that OLR1 is not required for the transcriptional regulation induced by oxidized PAPC but interestingly, OLR1 knockdown affected expression of CNN2, HMRR, ITGB6 and KIF20A, all genes governing cell proliferation and motility. PMID: 29103984
  5. Data show that oxidized low density lipoprotein receptor 1 (LOX-1) is overexpressed in prostate cancer cells. PMID: 29107109
  6. expression significantly higher in the arterial wall of epicardial coronary arteries compared to intramyocardial coronary arteries PMID: 29448251
  7. let7g exerts a LOX1independent antiaging effect on endothelial cells. PMID: 29393358
  8. high LOX-1 expression in pancreatic cancer tissues is indicative for the occurrence of lymph node metastases, high TNM stages and a poor prognosis. PMID: 29168159
  9. lincRNAp21 is a major mediator of oxLDLinduced apoptosis and expression of LOX1 in human vascular endothelial cells, and acts via activation of PKCdelta. PMID: 28983628
  10. this study shows that LOX-1 is involved in IL-1beta production and extracellular matrix breakdown in dental peri-implantitis PMID: 28898769
  11. Results showed that the scFv with N-terminal fusing peptides proteins demonstrated increased LOX-1-binding activity without decrease in stability. These findings will help increase the application efficacy of LOX-1 targeting scFv in LOX-1-based therapy PMID: 29094051
  12. The serum sLOX-1 level was higher in patients with large artery atherosclerotic stroke, and it was an independent predictor of functional outcome in patients with large artery atherosclerotic ischemic stroke. PMID: 27967338
  13. LOX-1 has a role in atherogenesis and tumorigenesis as a potential link in these diseases [review] PMID: 29462603
  14. the rs1050283 T allele of LOX-1 is strongly associated with an increased risk for atherosclerotic cerebral infarction in a Chinese population, which also affects levels of LOX-1 and sLOX-1 PMID: 27840386
  15. data revealed that miR-let-7g exhibits anti-atherosclerotic activity, at least partially by targeting the LOX-1 signaling pathway. PMID: 28535009
  16. High LOX1 expression is associated with colorectal cancer. PMID: 26895376
  17. Increased LOX-1 expression in endothelial cells is potentially involved in the pathogenesis of sickle cell disease vasculopathy PMID: 27519944
  18. LOX-1 signalling and the crucial role of cytokines PMID: 28860004
  19. High OLR1 expression is associated with breast cancer. PMID: 28844714
  20. Multiple classical molecular dynamics simulations have been applied to the human LOX-1 receptor to clarify the role of the Trp150Ala mutation in the loss of binding activity. Results indicate that the substitution of this crucial residue, located at the dimer interface, markedly disrupts the wild-type receptor dynamics PMID: 28657156
  21. Carrying the C allele of the rs11053646 variant of the OLR1 gene was associated with an increased risk of CAD in heterozygous adult patients with FH, and this risk could be even greater in smokers as well as in younger patients. PMID: 28941610
  22. Berberine could prevent the oxLDL and TNFalpha - induced LOX1 expression and oxidative stress, key events that lead to NOX, MAPK/Erk1/2 and NF-kappaB activation linked to endothelial dysfunction. PMID: 28511903
  23. Individuals >/=30 years old with abdominal obesity presented lower Lox1 levels than patients >/=30 years old without abdominal obesity. PMID: 27525284
  24. These studies suggest that activation of LOX-1 expression occurs through binding of the chlamydial glycan and provides one mechanism by which Chlamydia pneumoniae infection could play a role in the pathogenesis of atherosclerosis. PMID: 23821487
  25. Elevated LOX1 is Associated with Acute Stroke. PMID: 27025681
  26. Xanthine oxidase induces foam cell formation in large part through activation of LOX-1 - NLRP3 pathway in both vascular smooth muscle cells and THP-1 cells. PMID: 28084571
  27. show that MiR-590-5p inhibits angiogenesis by targeting LOX-1 and suppressing redox-sensitive signals PMID: 26932825
  28. OLR1 rs1050286 SNP may contribute to modify OLR1 susceptibility to acute myocardial infarction and coronary artery diseases. PMID: 26542080
  29. Serum sLOX-1 level was significantly lower in the restless legs syndrome patient group compared to controls. PMID: 27546362
  30. The mechanistic link between miR-590-5p and LOX-1:miR-590-5p downregulation led to LOX-1 upregulation in endothelial cells. PMID: 26906623
  31. Serum LAB was associated with an increased carotid IMT in Japanese men, especially those with hypercholesterolemia PMID: 26892134
  32. the current meta-analysis highlighted that variant allele of OLR1 rs11053646 G > C and PCSK9 rs505151 A > G may contribute to the susceptibility risk of ischemic stroke. PMID: 26666837
  33. Silencing of LOX-1 gene expression abolished ox-LDL induced effects in cell viability, reactive oxygen species generation and gene expression. PMID: 26510581
  34. both the 501>C single nucleotide polymorphisms in the LOX1 gene and the serum LOX1 level may be used to predict the development of left ventricular hypertrophy among essential hypertension patients. PMID: 24480971
  35. for our Turkish sample group, LOX-1 30UTR188C/T and K167N polymorphisms may not be involved in susceptibility to GDM [gestational diabetes mellitus ] PMID: 26296941
  36. Cholesterol depletion triggers the release of LOX-1 in exosomes as a full-length transmembrane isoform and as a truncated ectodomain soluble fragment. PMID: 26495844
  37. Interaction between Lox-1, C-reactive protein and oxidized LDL play role in the pathogenesis of atherosclerosis. PMID: 26607724
  38. OLR1 is a novel molecular link between the proliferative and inflammatory responses of vascular smooth muscle cells. PMID: 26305474
  39. Ginkgo biloba extract inhibits oxLDL-induced matrix metalloproteinase activation by the modulation of the LOX1-regulated signaling pathway in human umbilical vein endothelial cells. PMID: 25080882
  40. Data show that the interplay between the two TNF receptors (TNFR1 and TNFR2) was apparent in the expression pattern of lectin-type oxidized LDL receptor 1 (LOX-1) in response to TNF-alpha. PMID: 25416967
  41. The serum LOX-1 levels were significantly higher in NAFLD patients than in healthy controls. PMID: 26185381
  42. Low shear stress is a regulator of autophagy and LOX-1 plays an important role in shear stress induced autophagy. PMID: 25697875
  43. results showed higher expression of HSP70 and LOX-1 in the placental tissues of pre-eclampsia patients which represent the possible contribution of these molecules in the disease pathogenesis. PMID: 24786389
  44. Elevated plasma sLOX-1 level on admission independently predicts long-term all-cause mortality and MACE after STEMI. PMID: 25746549
  45. biomarker for determining early endothelial damage in hypertension, especially in white coat hypertension PMID: 25007999
  46. LOX-1 activation by oxLDL is an important event that enhances tumor angiogenesis PMID: 25170920
  47. LOX-1 is the receptor that mediates oxidized LDL activity in vascular endothelial cells.Activation of LOX-1 causes endothelial dysfunction and vascular lipid deposition. PMID: 25463747
  48. Our data indicate a new direction for LOX-1 regulation by the modulation of the PKCbeta/NAPDH oxidase/SIRT1/HSF1 mechanism PMID: 25982096
  49. The present study showed that circulating soluble LOX-1 originates from coronary circulation and soluble LOX-1 and LOX-1 index are useful biomarkers for acute coronary syndrome. PMID: 24895597
  50. Meta-analysis results showed that the +1073 C/T polymorphism in ORL1 decreased the risk of Alzheimer's disease. This allele was predicted to affect the binding site of many miRNAs explaining the relationship between the +1073 C/T variant and the disease. PMID: 25501227
  51. higher plasma sLOX-1 and oxLDL concentrations, and the LOX-1 3'UTR188C>T and LOX-1 K167N gene polymorphisms were significantly associated with risk of developing preeclampsia. PMID: 25200690
  52. Increased serum ox-LDL level and OLR1 expression may indicate advanced-stage PCa and lymph node metastasis. Moreover, ox-LDL could stimulate PCa proliferation, migration, and invasion in vitro. PMID: 25566960
  53. Results characterized the contributions of individual SNP to OLR1 exon 5 alternative splicing and revealed SR protein family members (SRSF1, SRSF2) and HMGA1 as factors in promoting OLR1 exon 5 inclusion. PMID: 25904137
  54. In essential hypertensive patients, the T allele of OLR1/LOX-1 gene is strongly associated with an impaired endothelium-dependent vasodilatation, a powerful predictor of cardiovascular events PMID: 23054405
  55. central role in the pathogenesis of atherothrombotic disease [review] PMID: 25216847
  56. Results show that LOX-1 is a target of let- 7a and let-7b, and they inhibit the expression of LOX-1 by targeting its 3'-UTR. PMID: 25247304
  57. LOX-1-mediated autophagy and mitochondrial DNA damage play an essential role in NLRP3 inflammasome activation in inflammatory disease states PMID: 24776598
  58. This study unveils the presence of SR-A1, CD36, and LOX-1 in aortic valves and suggests potential mechanisms by which they may contribute to the pathological angiogenesis, inflammation, calcification, and lipid accumulation in AVS. PMID: 24929820
  59. LOX-1 expressed on dendritic cells and B cells promotes humoral responses. PMID: 25308333
  60. Did not find any correlation of LOXIN genotype with the severity or prognostic localization of coronary artery disease on left main and/or proximal LAD. PMID: 24743687
  61. TNF-alpha increases intracellular reactive oxygen speceis production in monocytes by inducing the expression of oxidant enzymes such as NOX2 and promotes Ac-LDL uptake by enhancing LOX-1 expression. PMID: 24518001
  62. Results of this study demonstrate that the TLR4/NF-kappaB signaling pathway has an important function in the up-regulation of oxLDL-induced expressions of LOX-1, MCP-1, and VCAM-1 in HUVECs. PMID: 24615033
  63. tThe G501C variant in the LOX-1 gene may be associated with susceptibility to cerebral infarction. PMID: 24661313
  64. identified 6 of the 8 components of the chaperonin-containing TCP-1 (CCT) complex bound to LOX-1 cytoplasmic domain PMID: 24846140
  65. Soluble LOX-1 levels (but not those of high-sensitivity C-reactive protein or troponon T) can differentiate acute coronary syndrome with plaque rupture from those without. PMID: 23632121
  66. LOX-1 expression is not associated with impairment of endothelium-dependent vasoreactivity in conduit vessels. PMID: 24101392
  67. Electronegative subfraction of low-density lipoprotein stimulated Local C-reactive protein production via LOX-1 in cultured human aortic endothelial cells. PMID: 23950953
  68. increased expression of IL-10 may help to attenuate the risk of atherosclerosis developed by pro-inflammatory signal(s) generated through the interaction of oxLDL with its cognate receptor LOX-1 on macrophages PMID: 23811604
  69. Soluble lectin-like oxidized LDL receptor is a valuable biomarker for acute aortic dissection. PMID: 23021597
  70. the structural and dynamical properties of the LOX-1 PMID: 24113299
  71. Data indicate that oxLDL doubled the transcripts of hyaluronan synthases HAS2 and HAS3 and hyaluronan deposition via the scavenger receptor LOX-1. PMID: 23979132
  72. The serum sLOX-1 level was found to increase in close association with both the smoking-related variables and the inflammatory marker C-reactive protein. PMID: 23665840
  73. Suggest LOX-1 as an early marker of endothelial damage in Behcet's disease. PMID: 24064019
  74. Serum LOX-1 ligand containing ApoB, a new candidate biomarker for residual risk, was associated with an increased carotid IMT in US Caucasian men independently of various risk factors. PMID: 23683938
  75. LOX-1 may play a bridging role in GLP-1 activation and reactive oxygen species interaction. PMID: 23806684
  76. data suggest that ox-LDL concentration polarization plays an important role in the localization of atherosclerotic lesions concomitant with LOX-1 dependent autophagy and apoptosis PMID: 23807658
  77. This study found that the OLR-1gene polymorphisms rs11053646 were associated withthe risk for IS and clinical outcome in a Chinesepopulation. PMID: 23535804
  78. Data suggest that serum soluble LOX-1/OLR1 concentration is associated with severity of peripheral artery disease (PAD; assessed by ankle-brachial index) in type 2 diabetes; thus, sLOX-1 could be biological marker for PAD in such patients. PMID: 23433938
  79. There was no rs3736232 and rs3736234 of OLR1 for risk of coronary atherosclerosis. PMID: 23391848
  80. demonstrated that LOX-1 was palmitoylated and that both cysteine 36 and cysteine 46 were necessary for the recruitment of LOX-1 into raft microdomains and for its ligand uptake ability PMID: 23583401
  81. exaggerated amount of oxLDL in UAP and interaction of oxLDL with LOX-1 receptor are amplified by the activation of octamere 1 with consequent activation of a series of inflammatory endothelial feed-back mechanisms resulting in LOX-1 gene over-expression. PMID: 23237633
  82. The OLR1 IVS4-14 GG polymorphism seems to be related to glucose metabolism disturbance, elevated insulin level and lipid peroxidation in patients with metabolic syndrome. PMID: 23134583
  83. Angiotensin (1-7) inhibited LOX-1 expression and diminished Ang II-mediated inflammation in endothelial cells PMID: 23233095
  84. LOX-1 up-regulation induced by AGE-BSA is receptor mediated through RAGE and is via the PI3K/PDK1/mTORC2 pathway PMID: 22863784
  85. High Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK. PMID: 22641216
  86. The level of plasma soluble LOX-1 and LOX-1 mRNA in peripheral mononuclear cells are significantly increased in acute coronary syndrome. PMID: 21177197
  87. LOX-1 activation by oxLDL and subsequent peroxynitrite generation as a novel mechanism by which disruption of the BBB occurs in EPE. PMID: 23230281
  88. Canonically formed C-type lectin-like domain dimer of LOX-1 is essential for its binding to OxLDL. PMID: 22369967
  89. the effect of 15-lipoxygenase-mediated modification of HDL3 on LOX-1 expression in the endothelial cells is reported. PMID: 23073138
  90. circulating sLOX-1 levels were associated with PCI-RPMI, which might predict periprocedural myocardial necrosis in elective NSV-PCI. PMID: 22797935
  91. Our findings suggest the involvement of some TNFSF/TNFRSF members and oxLDL in the early stages of atherogenesis; this may potentially contribute to the accelerated rate of atherosclerosis observed in individuals with FH. PMID: 22891927
  92. Losartan could attenuate the oxLDL- and Ang II-induced immune maturation of human monocyte-derived dendritic cells partly through downregulation of the LOX-1 expression. PMID: 22549450
  93. Significantly higher levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 are found in coronary artery ectasia patients when compared to control subjects with normal coronary arteries. PMID: 22271373
  94. study provides evidence that the miRNA hsa-let-7g inhibits LOX-1 expression/activation, proliferation and development of apoptosis in vascular cells PMID: 22956623
  95. Membrane cholesterol depletion inhibits LOX-1-mediated ox-LDL binding and internalization. PMID: 22570368
  96. DHA supplementation suppressed oxidized LDL (lectin-like) receptor 1 (OLR1). PMID: 21775114
  97. serum sLOX-1 levels were associated with pregnancy followed by delivery that might predict endothelial dysfunction PMID: 22619487
  98. LOX-1 may play a crucial role in the pathophysiological processes of intrahepatic cholestasis of pregnancy caused by over-apoptosis of trophocytes. PMID: 22905453
  99. the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process. PMID: 22347434
  100. serum-soluble LOX-1 levels were associated with proximal/mid segment of the left anterior descending artery lesion in patients with stable coronary artery disease PMID: 22116101

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Involvement in disease Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.; DISEASE: Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.
Subcellular Location Cell membrane, Lipid-anchor, Cell membrane, Single-pass type II membrane protein, Membrane raft, Secreted
Tissue Specificity Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate
Database Links

HGNC: 8133

OMIM: 602601

KEGG: hsa:4973

STRING: 9606.ENSP00000309124

UniGene: Hs.412484

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