Recombinant Human PR domain zinc finger protein 16 (PRDM16), partial

1. Study revealed that LINC00982 and PRDM16 may serve as biomarkers or potential drug targets for the diagnosis and therapy of lung adenocarcinoma. PMID: 30132554
2. Multiple regression analysis showed that age, male gender, body max index, presence of obesity, type-2-diabetes mellitus, hypertension and coronary artery disease and left ventricular ejection fraction were associated with the expression levels of UCP1, PGC1alpha and PRDM16 mRNA PMID: 28824327
3. Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially migraine without aura , among Chinese patients. It appears that there is no association with serotonin receptor related genes. PMID: 28058730
4. High PRDM16 expression is a significant predictive marker for poor prognosis in adult AML patients. PMID: 28710806
5. Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT. PMID: 28701693
6. Flow cytometric analysis and western blot analysis of apoptosisassociated proteins indicated that PRDM16 has an antiapoptotic role in prostatic cancer cells. In addition, the spliced form, sPRDM16/MEL1S, was detected to be overexpressed in PCa cell lines. In conclusion, the present study indicated an important oncogenic role in prostate cancer. PMID: 27511603
7. A single risk variant, rs2651899 in PRDM16, was significantly associated with efficacy of triptans in migraine patients PMID: 26502740
8. High PRDM16 expression is associated with astrocytoma. PMID: 26701852
9. Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia. PMID: 26559765
10. Results show that PRDM16 overexpression was highly recurrent in de novo paediatric AML and is associated with adverse outcome PMID: 26684393
11. PRDM16 might contribute to maintain adipose tissue "white fat" gene expression profile and systemic metabolic homeostasis. PMID: 25662275
12. EVI1 and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations have roles in Japanese pediatric acute myeloid leukemia PMID: 25567132
13. Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 locus) were associated with QRS duration; and rs17026156 (SLC8A1 locus) correlated with PR interval. PMID: 25035420
14. Genetic analyses uncovered the importance of the PRDM16 gene in the regulation of lean body mass. PMID: 24863034
15. MED1 is required for optimal PRDM16-induced Ucp1 expression PMID: 25644605
16. PRDM2, PRDM5, PRDM16 promoters are methylated and their expression is suppressed in lung cancer cells. PMID: 24966940
17. Mutations in gene encoding the transcriptional co-activator PRDM16 may be a cause of left-ventricular noncompaction and dilated cardiomyopathy. PMID: 24717670
18. The rs2651899 variant in PRDM16 plays a role in Chinese common migraine susceptibility. PMID: 24021092
19. An association between PRDM16 rs2651899 SNP and migraine in a Swedish case-control study. PMID: 24674449
20. No association between the four polymorphisms of the PRDM16 gene with essential hypertension. PMID: 24327154
21. Single nucleotide polymorphism Rs2236518 is associated with body mass index in the young Chinese males (using QTDT), and the older Chinese males (using GLM-ANOVA). PMID: 23524569
22. Mutation of PRDM16 causes the cardiomyopathy in 1p36 deletion syndrome as well as a proportion of nonsyndromic left ventricular noncompaction cardiomyopathy and dilated cardiomyopathy. PMID: 23768516
23. High PRDM16 expression is associated with pheochromocytoma. PMID: 23454374
24. Data identify Prdm3 and Prdm16 as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin. PMID: 22939622
25. genetic association studies in a Chinese Xinjiang Uygur population: Studies suggest that commonly occurring SNP in PRDM16 (rs2236518) shows a significant negative association with metabolic syndrome in a multivariable logistic regression analysis. PMID: 22383139
26. Survival data suggest that patients with AML/MDS and PRDM16 translocations have a poor prognosis despite a simple karyotype and a median age of 65 years. PMID: 22050763
27. genome-wide association studies have successfully identified four new genetic variants associated with migraine in the LRP1, TRPM8, and PRDM16 genes PMID: 22072275
28. Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus PMID: 22039459
29. Breakpoints occurring in the first intron and in the 5' region of the MEL1 gene associated with the t(1;3)(p36;q21) translocation have been found in three myelodysplastic syndrome/acute myelogenous leukemia patients. PMID: 12557231
30. structure, expression pattern, and function of MEL1 in leukemia cells; overexpression of the zinc finger protein lacking the PR domain (EVI1 and MEL1S)is likely one of the causative factors in the pathogenesis of myeloid leukemia. PMID: 12816872
31. Aberrant gene expression associated with DNA hypomethylation is implicated in leukemogenesis of adult T-cell leukemia. PMID: 14656887
32. Correction opf X-linked chronic granulomatous disease by gene therapy was augmented by insertional activation of PRDM16. PMID: 16582916
33. A 3' RACE experiments followed by sequence-specific RT-PCR resulted in the identification of the PRDM16 gene as a novel fusion partner of the RUNX1 gene in a patient with rare t(1;21)(p36;q22). PMID: 16598304
34. RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance PMID: 18202228
35. array CGH performed on CD34(+) cells revealed cryptic partial deletions of PRDM16. PMID: 18767145
36. SKI and MEL1 knockdown synergistically restored TGF-beta responsiveness in MKN28 cells and reduced tumor growth in vivo PMID: 19049980
37. PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown adipocytes. PMID: 19285866
38. PRDM16 and PGC-1 alpha expression was 2-fold greater in epicardial than sc fat. PMID: 19567523
39. data indicate that the PRDM16-C/EBP-beta complex initiates brown fat formation from myoblastic precursors PMID: 19641492

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HGNC: 14000

OMIM: 605557

KEGG: hsa:63976

STRING: 9606.ENSP00000270722

UniGene: Hs.99500