Recombinant Human Plasma membrane calcium-transporting ATPase 2 (ATP2B2), partial

1. PMCA2 regulates breast cancer cell proliferation and sensitivity to doxorubicin in basal cell carcinoma. PMID: 27148852
2. Cytoskeleton dynamics regulates plasma membrane PMCA2 activity. PMID: 28527708
3. Data show that ATPase, calcium transporting, plasma membrane 2 protein (PMCA2) silencing augmented B-cell leukemia 2 family proteins (Bcl-2) inhibitor ABT-263-mediated MDA-MB-231 breast cancer cell death. PMID: 27613092
4. NHERF1 acts with PMCA2 to regulate HER2 signaling and membrane retention in breast cancers PMID: 28235801
5. PMCA2 interacts with HER2 in specific actin-rich membrane domains. PMID: 26729871
6. PMCA2b resulted in rapid and highly PMCA abundance-sensitive clearance of store-operated Ca2+ entry-mediated Ca2+ transients. PMID: 25690014
7. ATP2B2 might play a role in the etiology of autism in Chinese Han population. PMID: 23620727
8. G293S and V586M mutations in the PMCA2 Calcium Transporting ATPase of the stereocilia are associated with deafness. (Review) PMID: 22349217
9. The human mutant of PMCA2 exacerbated the deafness produced by a cadherin 23 mutation. The human mutant failed to impair the Ca(2+) ejection by the pump. PMID: 22047666
10. These results provide converging evidence for an association between ATP2B2 gene variants and autism in male subjects PMID: 21757185
11. these data suggest that full polarization is a prerequisite for proper positioning of the PMCA2w variants in the apical membrane domain of polarized cells. PMID: 21672522
12. It appears that Ca extrusion via the sarcolemmal Ca ATPase occurs only at the t-tubules, and is not regulated by basal PKA activity. PMID: 20971118
13. Report a novel interaction between endogenous plasma membrane calcium ATPase (PMCA) and eNOS in endothelial cells. PMCA may negatively modulate eNOS activity, and NO-dependent signal transduction pathways. PMID: 20211863
14. Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells. PMID: 20663896
15. Alternative splicing of the first intracellular loop of PMCA2 alters its membrane targeting PMID: 12624087
16. Decrease in PMCA2 transcript and protein levels and correlation between expression and disease course in two different allergic encephalomyelitis models further highlight the importance of this calcium pump in neuronal dysfunction during inflammation. PMID: 15926914
17. We conclude that PMCA2 mRNA can be highly overexpressed in some breast cancer cells. PMID: 16216224
18. plasma-membrane calcium-pump isoform 2 mutants have roles in causing digenic deafness PMID: 17234811
19. Our results indicate that a loss of PMCA such as occurs in aging brain likely leads to subtle disruptions in normal Ca(2+) signaling and enhanced susceptibility to stresses that can alter the regulation of Ca(2+) homeostasis. PMID: 17488275
20. The deaf-waddler isoform of PMCA2, operating at 30% efficacy, showed a significantly decreased ability to rescue the Ca(2+) loading of cells expressing TRPML3(A419P). PMID: 19299509
21. These data indicate that alternative splicing differentially affects the lipid interactions of PMCA2w/b and PMCA2z/b and that the apical localization of PMCA2w/b is lipid raft-dependent and sensitive to cholesterol depletion. PMID: 19379709
22. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19850283

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HGNC: 815

OMIM: 108733

KEGG: hsa:491

STRING: 9606.ENSP00000324172

UniGene: Hs.268942