Recombinant Human Regulator of G-protein signaling 13 (RGS13)

Code CSB-YP019645HU
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Source Yeast
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Code CSB-EP019645HU
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Source E.coli
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Code CSB-EP019645HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP019645HU
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Source Baculovirus
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Code CSB-MP019645HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
RGS13
Uniprot No.
Alternative Names
AL713991.1; HGNC:9995; MGC17173; OTTMUSP00000022853; OTTMUSP00000022854; Regulator of G protein signalling 13; Regulator of G-protein signaling 13; RGD1562103; RGS 13; RGS13; RGS13_HUMAN; RP11 92K2.1
Species
Homo sapiens (Human)
Expression Region
1-159
Target Protein Sequence
MSRRNCWICK MCRDESKRPP SNLTLEEVLQ WAQSFENLMA TKYGPVVYAA YLKMEHSDEN IQFWMACETY KKIASRWSRI SRAKKLYKIY IQPQSPREIN IDSSTRETII RNIQEPTETC FEEAQKIVYM HMERDSYPRF LKSEMYQKLL KTMQSNNSF
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha.
Gene References into Functions
  1. p53 may modulate immune responses through suppression of RGS13 transcription in mast cells and B cells PMID: 21531726
  2. RGS13 turnover was significantly reduced in cells stimulated with cAMP, which was reversed by expression of the PKA-specific inhibitory peptide PKI. PMID: 20974683
  3. Functional characterization of the G protein regulator RGS13 PMID: 11875076
  4. Down-Regulation of regulator of G-protein signalling 13 is associated with mantle cell lymphoma PMID: 12970790
  5. RGS13 overexpression inhibited CXCL12-evoked Ca(2+) mobilization, Akt phosphorylation and chemotaxis. PMID: 19017978

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Database Links

HGNC: 9995

OMIM: 607190

KEGG: hsa:6003

STRING: 9606.ENSP00000375853

UniGene: Hs.497220

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