Recombinant Human SLIT and NTRK-like protein 1 (SLITRK1), partial

Code CSB-YP842740HU
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Source Yeast
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Code CSB-EP842740HU
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Source E.coli
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Code CSB-EP842740HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP842740HU
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Source Baculovirus
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Code CSB-MP842740HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SLITRK1
Uniprot No.
Alternative Names
SLITRK1; KIAA1910; LRRC12; UNQ233/PRO266; SLIT and NTRK-like protein 1; Leucine-rich repeat-containing protein 12
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth.
Gene References into Functions
  1. Altogether, these results demonstrate that Slitrk family proteins regulate synapse formation. PMID: 27273464
  2. Data provide partial support for the implication of SLITRK1 in the pathogenesis of Tourette syndrome. PMID: 26317387
  3. the N400I variant of SLITRK1 may have a role in obsessive-compulsive disorder PMID: 23990902
  4. The study of chromosomal aberrations in Tourette syndrome etiology has implicated multiple genes, with SLITRK1 being the most prominent example. PMID: 23333760
  5. One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes PMID: 23528612
  6. DM1 motoneuron/muscle cell cocultures showed alterations that are consistent with the known role of SLITRK genes in neurite outgrowth, neuritogenesis, and synaptogenesis; functional defects can be directly attributed to SLITRK misexpression. PMID: 21458401
  7. The study of this study support that SLITRK1 var321 is association to Tourette syndrome. PMID: 20351724
  8. findings support the association of rare SLITRK1 sequence variants with Tourette's syndrome PMID: 16224024
  9. SLITRK1 trouble in Tourette's syndrome. PMID: 16323357
  10. No variation in patients susceptible to obsessive-compulsive disorder.( PMID: 16936762
  11. Rare variations in SLITRK1 result in disorders of the obsessive-complusive disease spectrum PMID: 17003809
  12. negative results of the SLITRK1 analysis point to genetic heterogeneity in Tourette syndrome PMID: 17712845
  13. identified four new variants for Gilles de la Tourette syndrome PMID: 18004766
  14. Genetic screening in the Slit and Trk-like 1 gene for the recently identified mutations does not appear to be of utility in the diagnosis of Tourette syndrome. PMID: 18021920
  15. Observed transmission is lacking of SLITRK1 var321 from an affected parent to a child with Tourette syndrome in two families segregating this variant. PMID: 18413575
  16. These findings provide the first support for the original finding indicating SLITRK1 as a susceptibility gene for Gilles de la Tourette Syndrome PMID: 18698576
  17. We report the psychopathological features in a large Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene. PMID: 18722020
  18. results provide no evidence for SLITRK1 playing a major role in Tourette disease PMID: 19018236

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Involvement in disease
Trichotillomania (TTM)
Subcellular Location
Membrane; Single-pass type I membrane protein. Secreted. Cell junction, synapse.
Protein Families
SLITRK family
Tissue Specificity
Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
Database Links

HGNC: 20297

OMIM: 609678

KEGG: hsa:114798

STRING: 9606.ENSP00000366288

UniGene: Hs.415478

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