Recombinant Human Segment polarity protein dishevelled homolog DVL-1 (DVL1)

1. loss of p53 or LKB1 relieves DVL-linked reciprocal inhibition between the Wnt and nuclear YAP activity PMID: 29895829
2. Lack of DVL prevents NEK2-controlled dissolution of loose centrosomal linker and subsequent centrosomal separation. Increased DVL levels, in contrast, sequester centrosomal NEK2 and mimic monopolar spindle defects induced by a dominant negative version of this kinase. PMID: 27486244
3. These results identify USP4 as a novel regulator of Dvl in Wnt/beta-catenin signal and show its involvement in Wnt3a-induced osteoblast differentiation PMID: 27128386
4. Authors conclude that the planar cell polarity (PCP) pathway contributes significantly to the motility and hence the invasiveness of glioblastoma multiforme (GBM) cells, and that Nrdp1 acts as a negative regulator of PCP signaling by inhibiting Dvl through a novel polyubiquitination mechanism. PMID: 28481871
5. two mutually exclusive functions of the DEP domain in Wnt signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported. PMID: 27744318
6. we show that Wnt5a rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome. PMID: 27500936
7. Data show that dishevelled proteins DVL1, 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs). PMID: 27086035
8. The secreted frizzled-related protein and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors. PMID: 27599467
9. Data show that receptor for activated C kinase 1 (RACK1) interacts with Dishevelled (Dvl) proteins and promotes their lysosomal degradation, and this effect is enhanced by autophagy induction. PMID: 27129200
10. TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVLl. PMID: 26325443
11. Specific -1 frameshift variants in the penultimate exon of DVL1 cause autosomal-dominant Robinow syndrome. PMID: 26924530
12. Results show that coexpression of IQGAP1 and Dvl in the cytoplasm and nucleus was correlated with the lymph nodal metastase and poor prognosis of non-small cell lung cancer. PMID: 25436461
13. Data indicate Dishevelled (DVL) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity. PMID: 25891077
14. silencing DVL1 sensitized A2780/Taxol cells to paclitaxel, by down-regulating AKT/GSK-3beta/beta-catenin signalling, providing a novel strategy for chemosensitization of ovarian cancer to paclitaxel-induced cytotoxicity. PMID: 25643607
15. Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome, with the osteosclerosis possibly the result of an interaction between the wild-type and mutant alleles, leading to elevated canonical Wnt signaling. PMID: 25817014
16. DVL1 frameshift mutations clustering in the penultimate exon cause autosomal-dominant Robinow syndrome. PMID: 25817016
17. Authors propose a model for Rac1 activation where SIRT1/2 positively modulates the DVL/TIAM1/Rac1 axis and promotes sustained pathway activation. PMID: 24362520
18. Dvl overexpression may contribute to the malignant proliferation and invasion of human glioma. PMID: 25043531
19. DVL is a master regulator of FZD6/G-protein signaling PMID: 24500924
20. DVL1 was localized in the cytoplasm of CRC cells. PMID: 24129181
21. Study showed an association of DVL-1 and DVL-3 with Hirschsprung's disease. PMID: 24040443
22. findings did not provide evidence for the implication of DVL1 in the pathogenesis of human NTDs. PMID: 23836490
23. Data reveal a novel Rac1-dependent signalling pathway that, through Nedd4-mediated ubiquitylation of Dvl1, stimulates the maturation of epithelial cell-cell contacts. PMID: 22467858
24. 14-3-3beta interacts with human Dapper1, attenuating the ability of hDpr1 to promote Dishevelled (Dvl) degradation, thus enhancing Wnt signaling PMID: 21262972
25. TMEM88 associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner PMID: 21044957
26. Study demonstrate that the DIX domains of Dvl and Axin are expressed noticeably in a multi-cistronic system but not in a mono-cistronic system. PMID: 20846493
27. Dishevelled signals through LRP5/6 in human cells and Drosophila embryos. PMID: 20388731
28. NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation. PMID: 20177058
29. The DVL1 gene spans a region of approximately 13.8 kb with 15 exons and six rare sequence variations. None of these had any association with late onset AD. PMID: 11803455
30. Amplification and increased expression of the DVL-1 gene is associated with breast carcinogenesis PMID: 12824876
31. amplification and increased expression of the DVL-1 gene may play some role in the development of a portion of human cervical squamous cell cancer through derangement of the Wnt signaling pathway PMID: 12883684
32. interaction among misfolded SOD1, NEDL1, translocon-associated protein-delta, and Dishevelled-1 forms a ubiquitinated protein complex that is included in potentially cytotoxic protein aggregates PMID: 14684739
33. Ccd1 drastically inhibited JNK activation both by Axin and by Dvl. PMID: 15262978
34. DVL1 was overexpressed in prostate cancer and its overexpression might be related to prostate cancer progression through the Wnt/beta-catenin pathway. PMID: 16457155
35. The expression of Dishevelleds in mammalian cells provide an estimate of the relative cellular abundance of each Dvl. PMID: 18093802
36. a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1 PMID: 18162551
37. Our results reveal a mechanism by which nuclear Dvl cooperates with c-Jun to regulate gene transcription stimulated by the canonical Wnt signaling pathway. PMID: 18347071
38. the C6 motif seems to reduce the interaction of Axin with Dvl-1. PMID: 18632848
39. Expression of Dvl-1, Dvl-2 and Dvl-3, is common in non-small cell lung cancer PMID: 18692936
40. These results suggest that membrane accumulation of Par1b induced by Dvl is regulated by its phosphorylation status, which is important for Par1b to regulate the microtubule dynamics. PMID: 18760999
41. Dvl directly interacted with and activated PI4KII alpha by increasing its V(max) for ATP and PtdIns. In addition, Dvl regulated PI4KII alpha and PIP5KI via different domains. PMID: 19561074

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HGNC: 3084

OMIM: 601365

KEGG: hsa:1855

STRING: 9606.ENSP00000368169

UniGene: Hs.731450