Recombinant Human Sulfate anion transporter 1 (SLC26A1), partial

Code CSB-YP880953HU
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Source Yeast
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Code CSB-EP880953HU
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Source E.coli
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Code CSB-EP880953HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP880953HU
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Source Baculovirus
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Code CSB-MP880953HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SLC26A1
Uniprot No.
Alternative Names
EDM4; S26A1_HUMAN; SAT 1; SAT-1; SAT1; Slc26a1; solute carrier family 26 (anion exchanger); member 1; solute carrier family 26 (sulfate transporter); member 1; Solute carrier family 26 member 1; sulfate anion tranporter AT1; Sulfate anion transporter 1; sulfate transporter; sulfate/anion transporter SAT 1 protein; sulfate/anion transporter SAT1 protein
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.
Gene References into Functions
  1. SLC26A1 L348P was associated with lower whole-body bone mineral density (BMD) and higher serum calcium, consistent with the osteochondrodysplasia exhibited by dogs and sheep with naturally occurring, homozygous, loss-of-function mutations in Slc13a1 PMID: 27412988
  2. Human SLC26A1 resembles SLC26 paralogs in its inhibition. PMID: 27125215
  3. Mutations in SLC26A1 gene is associated with Nephrolithiasis. PMID: 27210743
  4. Screened the SLC26A1 gene in a cohort of 13 individuals with recurrent calcium oxalate urolithiasis, which is the commonest type. DNA sequence analyses showed missense mutations in seven patients. PMID: 24250268
  5. SLC26A1 protein,point mutation is highly responsible for the hearing loss of newborns. PMID: 23815884
  6. The oxalate precursor glyoxylate was identified as a substrate of sat-1. Upregulated expression of sat-1 mRNA and of sat-1 protein indicates that glyoxylate may be responsible for the elevated oxalate release from hepatocytes observed in hyperoxaluria. PMID: 21093948
  7. Characterization of the SAT1 gene and protein function. PMID: 12713736
  8. The expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas), was evaluated. PMID: 17119850
  9. No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA. PMID: 17881426

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Involvement in disease
Nephrolithiasis, calcium oxalate (CAON)
Subcellular Location
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.
Protein Families
SLC26A/SulP transporter (TC 2.A.53) family
Tissue Specificity
Expressed most abundantly in the kidney and liver, with lower levels in the pancreas, testis, brain, small intestine, colon, and lung.
Database Links

HGNC: 10993

OMIM: 167030

KEGG: hsa:10861

STRING: 9606.ENSP00000354721

UniGene: Hs.658244

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