Recombinant Human Suppressor of tumorigenicity 7 protein (ST7), partial

Code CSB-YP865116HU1
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Source Yeast
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Code CSB-EP865116HU1
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Source E.coli
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Code CSB-EP865116HU1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP865116HU1
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Source Baculovirus
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Code CSB-MP865116HU1
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ST7
Uniprot No.
Alternative Names
ST7; FAM4A1; HELG; RAY1; Suppressor of tumorigenicity 7 protein; Protein FAM4A1; Protein HELG
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May act as a tumor suppressor.
Gene References into Functions
  1. The tumor suppressor ST7 is a key gene silenced by PRMT5. PMID: 24453002
  2. ST7 mediates tumor suppression through the regulation of the genes involved in maintaining the cellular structure of the cell and involved in oncogenic pathways PMID: 20238225
  3. Mutational analysis of ST7 in a wide range of cell lines and primary epithelial cancer failed to detect mutations at this locus, with the exception of 1 missense change in a breast cancer cell line. PMID: 12107844
  4. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system PMID: 12213198
  5. The ST7 gene is not a primary target of inactivation in most human cancers with loss of heterozygosity at 7q31.1-q31.2. PMID: 12231539
  6. These data suggest that LOH at 7q31-q35 is involved in the origin or progression of at least a subset of esophageal carcinomas, but that ST7 is not the target gene of this somatic event. PMID: 12545169
  7. somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors PMID: 14534688
  8. ST7 gene may not be the target gene of inactivation at 7q31 site in gastric carcinoma. PMID: 14669308

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
ST7 family
Tissue Specificity
Ubiquitously expressed, with highest levels in heart, liver and pancreas.
Database Links

HGNC: 11351

OMIM: 600833

KEGG: hsa:7982

STRING: 9606.ENSP00000265437

UniGene: Hs.368131

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