Recombinant Human Tyrosine-protein kinase Yes (YES1)

1. The downregulation of miR-199a contributes to paclitaxel (PTX) resistance in prostate cancer. YES1 mediates the regulation of miR-199a in prostate cancer PTX resistance. PMID: 29204706
2. findings identify acquired amplification of YES1 as a recurrent and targetable mechanism of resistance to EGFR inhibition in EGFR-mutant lung cancers and demonstrate the utility of transposon mutagenesis in discovering clinically relevant mechanisms of drug resistance. PMID: 29875142
3. Study on the role of miR-140-5p in inhibiting tumorigenesis in gastric cancer thru targeting YES proto-oncogene 1(YES1). PMID: 28818100
4. Our results suggest that H19 functions as a competitive endogenous RNA (ceRNA) by acting as a sink for miR-17-5p, revealing a potential ceRNA regulatory network involving H19 and miR-17-5p with a role in the modulation of YES1 expression PMID: 27093644
5. c-Yes plays an important role in migration and invasion of epithelial ovarian cancer. PMID: 27289010
6. Up-regulation of miR-210 inhibits hepatocellular carcinoma cell proliferation. Yes1 is a target of miR-210 and affects cell proliferation in HCC. PMID: 26676187
7. findings indicate that miR-203 induces the apoptosis of KB cells by directly targeting Yes-1, suggesting its application in anti-cancer therapeutics PMID: 25910964
8. Results demonstrate a unique role for Yes in phosphorylation of FAK and in promoting PCa metastasis. Therefore, phosphorylated FAK Y861 and increased Yes expression may be predictive markers for PCa metastasis. PMID: 25868388
9. results indicated that miR-17-5p might play a role in human ovarian cancer by up-regulating YES1 expression. PMID: 25561420
10. Increased YES/SFK activation might serve as a clinical biomarker for predicting tumor resistance to IGF-1R inhibition. PMID: 25925378
11. YES1 and YAP transcript levels were higher in liver metastases of patients with colon cancer after 5FU-based neoadjuvant chemotherapy. PMID: 24323901
12. YES kinase as a proximal glucose-specific signal in the Cdc42-signaling cascade. PMID: 24610809
13. we identified CRKL/YES as critical interrelated pathways necessary for rhabdomyosarcoma cell growth and survival and suggest a potential therapeutic role of SRC family kinase inhibition in the treatment of rhabdomyosarcoma. PMID: 23318429
14. Expression of HPV type 16 E7 resulted in increase in Src and Yes proteins level, but did not alter the level of Fyn. PMID: 23497302
15. Taken together, our findings demonstrate that Yes and Lyn phosphorylate EGFR at Y1101, which influences EGFR nuclear translocation in this model of cetuximab resistance. PMID: 22430206
16. study concludes that Yes is a central mediator for malignant mesothelioma cell growth that is not shared with other Src family kinases such as c-Src PMID: 22948717
17. c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that is not shared with c-Src. PMID: 21390316
18. Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3. PMID: 21454696
19. Yes-associated protein may play important roles in different pathways in distinct lung tumor subtypes. PMID: 21190720
20. c-Yes was expressed in malignant melanoma, and squamous cell carcinoma type skin neoplasms. PMID: 20796316
21. Cloning of the complete coding sequence of the cDNA of the Csk and Yes tyrosine kinases genes of the human lymphocytes and retina have been carried out. PMID: 19757166
22. Both YES and STAT1 were verified as direct miR-145 targets PMID: 20098684
23. Study identified the previously reported pathogenic mutation of NTRK3 in a KRAS/BRAF wild-type tumor and 2 somatic mutations in the Src family of kinases (YES1 and LYN) that would be expected to cause structural changes. PMID: 19893451
24. Data show that found that IFIH1, a susceptibility gene of type 1 diabetes, interacts with YES1, which plays a role in glucose transport. PMID: 19797678
25. cAMP activates while Ca(2+) inhibits human sperm c-yes kinase activity PMID: 12080032
26. QM binds to c-yes at the SH3 domain in tumor cell lines PMID: 12138090
27. This review summarizes the potential functions of c-Yes and its ability to modulate signals that are distinct from c-Src. PMID: 12456296
28. Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95 PMID: 15039424
29. activation of c-Yes is important for maintaining embryonic stem cells in an undifferentiated state PMID: 15148312
30. c-Yes 3'-UTR contains at least three newly identified adenine/uridine-rich elements (AREs) which are bound specifically by ARE-binding proteins HuR and AUF1. PMID: 16289864
31. Vascular endothelial growth factor (VEGF)-induced cell migration is significantly decreased in Yes-deficient retinal microvascular endothelial cells. PMID: 16400523
32. activation of the protooncogene product c-Yes may play a significant role in the malignant transformation of hepatocytes PMID: 17007035
33. The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer. PMID: 17109515
34. Nucleus-located c-Yes may be a useful marker to detect early-stage hepatocellular carcinoma. PMID: 17143518
35. Amyloid aggregation by an SH3 domain from the Src family. PMID: 17418139
36. Thus, these results suggest that endogenous c-Src, c-Yes, and Lyn are differentially activated through Cdc2 activation during M phase. PMID: 17692281
37. c-Yes induction results in increased colorectal carcinoma cell motility but did not promote proliferation. In later stages of colorectal carcinogenesis, elevations in c-Yes levels/activity may promote cancer spread & metastasis rather than tumor growth. PMID: 17898870
38. Binding of CD95 Ligand to CD95 on glioblastoma cells recruit Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases. PMID: 18328427
39. These results suggest that SFK trafficking is specified by the palmitoylation state in the SH4 domain. PMID: 19258394

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HGNC: 12841

OMIM: 164880

KEGG: hsa:7525

STRING: 9606.ENSP00000324740

UniGene: Hs.194148