Recombinant Human Unconventional myosin-VI (MYO6), partial

1. Backfolding of MVI regulates its ability to bind DNA and that a putative transcription co-activator NDP52 relieves the auto-inhibition of MVI to enable DNA binding. Additionally, we show that the MVI-NDP52 complex binds RNAPII, which is critical for transcription, and that depletion of NDP52 or MVI reduces steady-state mRNA levels. PMID: 29187741
2. The tumorigenic effect of lncRNA SOX21-AS1 in CRC cells via targeting miR-145/MYO6, providing a novel insight for CRC carcinogenesis. PMID: 29217166
3. Rab33b, OATL1 and Myo6 have roles in nanoparticle trafficking in HeLa cells PMID: 27374232
4. miR-143 and miR-145 suppress gastric cancer cell migration and metastasis by inhibiting MYO6 expression and the epithelial-mesenchymal transition, which provides a novel mechanism and promising therapeutic target for the treatment of gastric cancer metastasis. PMID: 29022908
5. MYO6 facilitates Salmonella invasion.Salmonella virulence effector SopB requires MYO6 to regulate the localization of phosphoinositides and Akt activation. PMID: 28348208
6. Data indicate filopodia formation and MYO6 motor function at endosomes and at the plasma membrane. PMID: 28143933
7. we describe a novel nonsense MYO6 mutation that was responsible for the hearing loss in a Brazilian family PMID: 29044474
8. this is the first ILDR1 and MYO6 mutations recognized in the southwest Iran. Our data expands the spectrum of mutations in ILDR1 and MYO6 genes PMID: 29224747
9. MYO6 could play an essential role in the growth of OSCC cells via regulation of cell cycle progression and apoptosis. PMID: 27561828
10. characterisation of the human myosin VI deafness mutant (R1166X) suggests that defects in cargo binding may leave myosin VI in a primed/activated state with an increased actin-binding ability PMID: 27474411
11. PRAS40 was downregulated in the DU145 cells following MYO6 knockdown. PMID: 27431378
12. knockdown of MYO6 slightly arrested cell cycle in G0/G1 phase, but remarkably increased the proportion of the sub-G1 phase of cell with the increase of apoptotic cells in colorectal cancer PMID: 27044563
13. study indicates that MYO6 may play an important role in gastric cancer tumorigenesis and may serve as a potential therapeutic target in human gastric cancer. PMID: 27515005
14. This study identified an isoform-specific regulatory helix, named the alpha2-linker, that defines specific conformations and hence determines the target selectivity of human myosin VI. PMID: 26950368
15. Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. PMID: 27018747
16. Knockdown of myosin VI significantly suppressed melanoma cell viability and proliferation. PMID: 26324058
17. Knockdown of MYO6 markedly reduced cell viability and colony formation, as well as suppressed cell cycle progression in breast cancer cells. PMID: 26407123
18. MYO6 was highly expressed in hepatocellular carcinoma. PMID: 25703929
19. MYO6 is crucial in maintaining cell cycle and cell growth of lung cancer cells.MYO6 is highly expressed in human lung cancer tissues. PMID: 25643992
20. Optineurin binding to myosin VI was also decreased in tissue lysates from sporadic amyotrophic lateral sclerosis spinal cords. PMID: 25859013
21. we demonstrate that myosin VI and TAX1BP1 are recruited to ubiquitylated Salmonella and play a key role in xenophagy PMID: 26451915
22. The frameshift deletion in MYO6 was confirmed as the causative variant for this dominant nonsyndromic hearing loss DFNA22 family PMID: 25227905
23. Several postulated mechanisms of function for actin cytoskeleton and MVI during subsequent steps of clathrin-dependent endocytosis are discussed in this review. PMID: 26263762
24. Four mutations of MYO6 protein were found in seven Japanese families exhibiting autosomal dominant inheritance of hearing loss. PMID: 25999546
25. Myosin VI mediates the movement of NHE3 to the microvillus in intestinal epithelial cells. PMID: 24928903
26. In myopathies associated with fiber atrophy, the amount of MVI was enhanced and its localization in affected fibers was changed. PMID: 25125183
27. Three mutations (p.R825X, p.R991X and Q918fsX941) produce a premature truncation of the myosin VI protein. p.R205Q, was associated with diminished actin-activated ATPase activity and actin gliding velocity of myosin VI in an in vitro analysis. PMID: 25080041
28. The central regions of the cadherin tail adjacent to the juxtamembrane sequence also display binding activity for Myo VI-CBD. PMID: 23007415
29. Myo6 plays a critical role in the fusion of endosome/lysosome in Rmc epithelial cells. Deficiency of myo6 compromises the epithelial barrier function PMID: 24028494
30. we identified a novel MYO6 mutation at the splice acceptor site of exon 7 (c.554-1G>A) in an extended German family with autosomal dominant postlingual non-syndromic hearing impairment. PMID: 23635807
31. Report Dutch family with progressive autosomal dominant sensorineural hearing loss caused by a mutation in MYO6 resembling presbyacusis. PMID: 23340379
32. analysis of the dynamic exchange of myosin VI on endocytic structures PMID: 22992744
33. It was shown that that myosin VI, in concert with Tom1, plays a crucial role in autophagy. Tom1 was identified as a myosin VI binding partner on endosomes. PMID: 23023224
34. detailed kinetic characterization of the myosin-6 motor domain PMID: 22884421
35. myosin VI regulates the organization of actin dynamics at the surface of a specialized organelle PMID: 22321127
36. Studies from crystallographic structures of myosin VI have revealed that rearrangements within the converter subdomain occur. PMID: 22171985
37. In this review, we describe the structure, kinetic properties and functions proposed for myosin VI, and present current hypotheses on the mechanisms of functioning of this unique protein in vivo. PMID: 21735821
38. results suggest a novel role for myosin VI and optineurin in regulation of fusion pores formed between secretory vesicles and the plasma membrane during the final stages of secretion PMID: 21148290
39. Role of insert-1 of myosin VI in modulating nucleotide affinity. PMID: 21278381
40. In migratory cells ablation of myosin VI or optineurin inhibits the polarized delivery of the epidermal growth factor receptor into the leading edge and leads to profound defects in lamellipodia formation. PMID: 20604900
41. Study suggests 2 tilt angles during myo6 stepping, corresponding to the pre- & post powerstroke states regulating leading head; large steps with hand-over-hand mechanism & small steps with inchworm-like mechanism increasing in frequency with ADP. PMID: 20850010
42. Myosin VI is differentially regulated by DNA damage in p53- and cell type-dependent manners. PMID: 20576604
43. This study describes the phenotype of 2 Belgian families with SNHL linked to DFNA22, both with a pathogenic change in the deafness gene MYO6. PMID: 19893302
44. Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer. PMID: 20353999
45. Data show that downregulation of myosin VI expression results in a significant reduction in PSA and VEGF secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI-interacting proteins, GIPC and LMTK2 and Dab2. PMID: 19855435
46. In families with recessively inherited deafness, DFNB37, our sequence analyses of MYO6 reveal a frameshift mutation (36-37insT), a nonsense mutation (R1166X), and a missense mutation (E216V) PMID: 12687499
47. Results report the effects of the C442Y mutation on the kinetics of the actomyosin ATP hydrolysis mechanism and motor function of myosin VI. PMID: 15123708
48. Inhibiting myosin VI expression in high-grade ovarian carcinoma cells impeded cell spreading and migration in vitro; optical imaging and histopathologic studies revealed that inhibiting myosin VI expression reduces tumor dissemination in nude mice PMID: 15146066
49. myosin VI and Dab2 facilitate CFTR endocytosis by a mechanism that requires actin filaments PMID: 15247260
50. a novel function for p53 in the maintenance of Golgi complex integrity and for myosin VI in the p53-dependent prosurvival pathway. PMID: 16507995

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HGNC: 7605

OMIM: 600970

KEGG: hsa:4646

STRING: 9606.ENSP00000358994

UniGene: Hs.149387