Recombinant Human Urocortin (UCN)

1. REVIEW: Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand? PMID: 28228090
2. In women with chronic pelvic pain, infertility, or both symptoms, the probability of endometriosis (positive predictive value) increased consistently with the increase of plasma Ucn1 levels. PMID: 28925754
3. Study found reduced miR-326 levels concomitant with elevated Ucn1 levels in Edinger-Westphal nucleus (EWcp) of depressed suicide completers and in the EWcp of depressed rats. In fully recovered rats, both serum and EWcp miR-326 levels rebounded to nonstressed levels. While downregulation of miR-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR-326 overexpression selectively reduced its levels. PMID: 27045550
4. In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma. PMID: 27567427
5. UCN I is secreted from human glioblastoma cells by exocytosis through constitutive secretory granules. PMID: 25239507
6. Findings identify Ucn as a potential mediator that inhibits TGFbeta1 oncogenic signaling in breast neoplasm. PMID: 26138318
7. In women with adnexal endometrioma versus teratoma, the medians were 105.31 pg/mL versus 120.84 pg/mL for urocortin, 7.16 pg/mL versus 9.13 pg/mL for leptin and 584.33 pg/mL versus 657.82 pg/mL for ghrelin (p > 0.05), respectively. PMID: 25951715
8. Ucn1 prevents the development of atherosclerosis by suppressing EC inflammatory response and proliferation, macrophage foam cell formation, and VSMC migration and proliferation PMID: 25462164
9. down-regulated expression in the placenta and maternal serum during intrahepatic cholestasis of pregnancy may impair the blood flow regulation of the utero-placental-fetal unit and contribute to fetal distress PMID: 25172671
10. Production of CRF and UCN1 in human dendritic cells is strongly augmented by commensal intestinal bacteria. PMID: 25339828
11. Cardioplegic arrest failed to induce cardiac myocyte overexpression of urocortin in diabetic hearts. PMID: 24954177
12. Urocortin expression inversely correlates with higher tumor grade and advanced tumor stage in gastric adenocarcinomas. PMID: 23531852
13. all neonates expressed UCN1 in the Edinger-Westphal nucleus independent of the degree of neuropathological injury. PMID: 24012814
14. Ucn is both an essential chondrocyte survival signal peptide and a chondroprotective agent in the presence of pro-apoptotic stimuli. PMID: 23846219
15. A detailed conformational model for the CRF1R-Ucn1 complex based on the many ligand-receptor interactions determined was here and eventually revealed unique features of peptide ligand binding to class B GPCRs. PMID: 24290358
16. during the midluteal phase of the cycle, metformin may decrease the production of corticotropin-releasing hormone and UCN in the endometrium. PMID: 23987517
17. Data suggest that low urocortin-1 concentration in midtrimester amniotic fluid is an early indicative marker of preterm birth. PMID: 23803006
18. Serum urocortin could not predict women who delivered preterm among women with signs of preterm labor. PMID: 22639902
19. Dihydrotestosterone decrease the expression of urocortin in human umbilical vein endothelial cells. PMID: 23801677
20. Confirm the anti-inflammatory function of VIP, through the modulation of the expression of CRF system that impacts in a reduction of mediators with inflammatory/destructive functions. PMID: 21360527
21. not found to be efficient in distinguishing endometrioma from other benign ovarian cysts or to be superior to CA125 in the diagnosis of endometrioma PMID: 20480172
22. nuclear translocation of Ucn along with the loss of CRFR2 in epithelial cells and microvasculature of tumoral specimens may be involved in the pathobiology of renal cell carcinoma PMID: 19437022
23. Women with endometriosis show an impaired endometrial expression of CRH and Ucn mRNA. PMID: 21289256
24. Higher plasma levels of urocortin-1, but not urocortin-II, are associated with worse left ventricular diastolic performance in patients with chronic systolic heart failure. PMID: 20670842
25. This article provides a review of the role of urocortins in normal cardiovascular physiology and in the pathophysiology of heart failure. PMID: 20363214
26. UCN is produced during the development of mesenchymal progenitor cells to osteoblasts and differentially regulated during culture as well as by differentiation factors. PMID: 19949969
27. Urocortin peptide and mRNA was significantly increased in women with preeclampsia. PMID: 15924674
28. Results demonstrate that plasma concentrations of UCN are significantly increased in patients with heart failure (HF). UCN may participate in the neurohumoral response of HF. PMID: 19961889
29. Results suggest that urocortin concentrations in the amniotic fluid of genetic amniocentesis are not predictive of preterm labor and birth. PMID: 19893766
30. The low amniotic fluid concentrations of urocortin at mid-trimester may be a signal of predisposition to preterm delivery. PMID: 19619932
31. a highly significant, but negative, correlation has been found between Ucn levels and gastric inflammation, suggesting that Ucn may exert an antiinflammatory effect in gastric mucosa PMID: 12519893
32. SCP and UCN are potent activators of the p42/44 MAPK pathway, with SRP able to induce phosphorylation of p42/44 MAPK as well, albeit not as pronounced PMID: 14519439
33. human cord blood-derived cultured mast cells (hCBMC) at 10 wk, but not at 2 wk, are immunocytochemically positive for CRH and UCN PMID: 14576187
34. Adipose tissue expressed urocortin and stresscopin, the predominant ligands of peripheral CRH-R2. PMID: 14764822
35. mRNA expression of urocortin was low during the last weeks of pregnancy in the placenta, myometrium and choriodecidua PMID: 15072543
36. urocortin may regulate uterine artery tone at mid gestation. PMID: 15784504
37. Urocortin potently suppressed the generation of angiotensin II-induced reactive oxygen species (ROS) in HUVECs. Tumor necrosis factor-alpha, interferon-gamma & pitavastatin increased the urocortin mRNA levels and its release from HUVECs. PMID: 16340217
38. CRH peptides can differentially influence hair follicle melanocyte behavior not only via CRH-R1 signaling but also by complex cross-talk between CRH-R1 and CRH-R2. PMID: 16675846
39. expression of UCN in extravillous trophoblast cells and the activation of the UCN gene promoter by the diacylglycerol/PKC pathway PMID: 16698078
40. The evidence that (i) UCN is highly expressed in the secretory phase of the endometrial cycle; (ii) cAMP & E(2) + MPA modulate secretion of UCN & (iii) UCN induces HESCs decidualization together suggest a possible role for UCN in endometrial physiology. PMID: 16920724
41. NPY, via NPY Y5 and to a lesser extent via the Y1 receptors, exerts a stimulatory action on Ucn1 cells in the nonpreganglionic Edinger-Westphal nucleus. PMID: 17154253
42. In allergic nasal mucosa, increased expression levels of urocortin and its receptors may contribute to increased mucosal swelling and vascular permeability, playing an important role in the pathogenesis of allergic rhinitis. PMID: 17597629
43. CRF-BP has distinct and separable binding surfaces for CRF and Ucn 1 PMID: 18234674
44. The Ucn1-mRNA level in non-preganglionic Edinger-Westphal nucleus neurons is about 9.12 times higher in male but unchanged in female suicide victims. PMID: 18329817
45. UCN inhibited the proliferation and promoted the apoptosis of endothelial cells and down-regulated VEGF expression in vivo via CRFR2. PMID: 18443956
46. Ucn showed a significant role in the regulation of local inflammation, proliferation, and relaxation of smooth muscle tone in different organs through activation of corticotropin releasing factor receptor 2 (CRFR2). PMID: 18670748
47. reverses LPS-induced TNF-alpha release from trophoblast PMID: 19703147
48. Plasma urocortin 1 is elevated in heart failure (in proportion to the degree of cardiac dysfunction) in concert with the generalized neurohormonal activation seen in this condition. PMID: 19808377

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HGNC: 12516

OMIM: 600945

KEGG: hsa:7349

STRING: 9606.ENSP00000296099

UniGene: Hs.534363