Recombinant Human Zinc finger protein ZFPM2 (ZFPM2), partial

1. The single nucleotide polymorphisms (SNPs) of NKX2.5, GATA4, and TBX5 are highly associated with congenital heart diseases in the Chinese population, but not significant in the SNPs of FOG2. PMID: 29972125
2. when ZFPM2R698Q was co-transfected with GATA4, BNP promoter activity increased significantly, whereas co-transfection with ZFPM2R736L and GATA4 did not significantly increase BNP promoter activity. This suggests that the R698Q mutation may affect the ability of ZFPM2 to bind GATA4. PMID: 29018978
3. Aberrant methylation status at the promoter CpG island shore of ZFPM2 gene may be associated with its gene transcription regulation in the tetralogy of fallot patients PMID: 26959486
4. Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. PMID: 28373160
5. ZFPM2 is a glioma susceptibility gene, its genotype and expression showing associations with incidence and severity. The balancing selection acting on ZFPM2 may relate to its roles in multiple organ development or associated disease etiology. PMID: 26207917
6. Isolated congenital diaphragmatic hernia was the predominant phenotype observed in our ZFPM2 mutation patients. PMID: 24702427
7. screened a larger CTD population, which comprised 145 tetralogy of Fallot (TOF), 37 double-outlet ventricle outflow (DORV), and 18 transposition of the great artery (TGA), to investigate exon mutations as well as copy number variations in ZFPM2/FOG2 PMID: 25025186
8. Whole exome sequencing identified independent missense mutations in FOG2 in two patients with 46,XY gonadal dysgenesis. PMID: 24549039
9. Findings indicate that zinc finger protein, multitype 2 protein (ZFPM2) plays a role in diaphragm and cardiovascular development. PMID: 24769157
10. Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes. PMID: 24743694
11. our results provide strong evidence regarding the susceptibility of the ZFPM2 gene to the development of non-syndromic TOF/DORV. PMID: 24469719
12. FOG1, FOG2 and GATA-6 modulate the transcriptional up-regulation of HAMP in hepatocytes during inflammation. PMID: 24179092
13. Variants of the ZFPM2/FOG2 gene might be a common cause of Double outlet right ventricle. PMID: 21919901
14. Sex Cord Stromal Tumors in childhood exhibited an embryonal gonadal phenotype, expressing a FOG-2/GATA-4 pattern in keeping with embryonal gonads. PMID: 23029311
15. association of the ZFPM2 SNP, rs12678719, with antipsychotic-induced parkinsonism PMID: 21947317
16. New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle PMID: 20807224
17. These results implicate FOG1 and 2 and CTBPs as partners of GATA proteins in the control of adipocyte proliferation and differentiation. PMID: 20705609
18. FOG-2 has specific role in fetal ovaries counteracting transactivation of mullerian-inhibiting substance gene by GATA-4. Important role for FOG-2 and GATA transcription factors in developing ovary. PMID: 12606418
19. AML1-FOG2 and FOG2-AML1 are expressed in myelodysplastic syndrome; results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of AML1 and GATA developmental programs in the disease pathogenesis PMID: 15705784
20. FOG-2 affects not only cardiac development but also gonadal function and its preservation PMID: 17309641
21. sequence variation in diaphragmatic hernia PMID: 17568391
22. SERCA2 is an important target of FOG-2 and that increased FOG-2 expression may contribute to a decline in cardiac function in end-stage heart failure by impaired T3 signaling PMID: 18658259
23. Comparative analyses identify USH and its human homolog, FOG2, as the targets of fly miR-8 and human miR-200, respectively; USH/FOG2 inhibits PI3K activity, suppressing cell growth in both flies and humans. PMID: 20005803

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HGNC: 16700

OMIM: 187500

KEGG: hsa:23414

STRING: 9606.ENSP00000384179

UniGene: Hs.431009