Recombinant Human immunodeficiency virus type 2 subtype A Gag polyprotein(gag) ,partial

Code CSB-YP322411HLU
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Source Yeast
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Code CSB-EP322411HLU
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Source E.coli
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Code CSB-EP322411HLU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP322411HLU
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Source Baculovirus
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Code CSB-MP322411HLU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names gag
Uniprot No. P18095
Alternative Names gag; Gag polyprotein; Pr55Gag) [Cleaved into: Matrix protein p17; MA); Capsid protein p24; CA); Spacer peptide 1; SP1; p2); Nucleocapsid protein p7; NC); Spacer peptide 2; SP2; p1); p6-gag]
Species Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Gag polyprotein
Gene References into Functions
  1. The differential requirement for adaptor protein complexes confirmed that HIV-1 and HIV-2 Gag have distinct cellular trafficking pathways, and that HIV-2 particles may be more susceptible to degradation prior to release. PMID: 27392064
  2. These data on HIV-2 indicate that the role of the matrix domain in the nucleic acid chaperone activity of Gag differs not only between, but also within, retroviral genera. PMID: 26987314
  3. These data show that infectious HIV-2 cannot bear the replacement of the reverse transcriptase Gln294 Pro, as it results in substantially reduced HIV-2 replication and fast reversions to the wild-type Gln294 virus. PMID: 25965791
  4. This showed that V111I changed the flexibility of the 110-to-115 loop region, which may affect deoxynucleoside triphosphate (dNTP) binding and polymerase activity. PMID: 25355888
  5. HIV-2 genome dimerization is required for the correct processing of Gag. PMID: 22419802
  6. The N-terminal and C-terminal domains of the integrase were highly conserved. PMID: 21114823
  7. analysis of the secondary active domain of HIV-2 NCp8 PMID: 17511966
  8. The results show that all modifications of HIV-2 RT Gln294 lead to an increase of the RNase H activity of the enzyme relative to the wild-type. PMID: 18625228
  9. C1-C4 region of HIV2 SU glycoprotein impairs utilization of the CCR5 and CXCR4 for viral entry. PMID: 19200444
  10. These results suggest that the splicing of both the 5'UTR intron and the C-box element have key roles in regulation of HIV-2 gag translation in vitro and in vivo. PMID: 19559029

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Subcellular Location Gag polyprotein: Host cell membrane, Lipid-anchor, Host endosome, host multivesicular body
Protein Families Primate lentivirus group gag polyprotein family

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