Recombinant Human respiratory syncytial virus B Non-structural protein 1 (1C)

Code CSB-YP335053HPX
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Source Yeast
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Code CSB-EP335053HPX
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Source E.coli
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Code CSB-EP335053HPX-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP335053HPX
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Source Baculovirus
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Code CSB-MP335053HPX
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
1C
Uniprot No.
Alternative Names
1C; NS1; Non-structural protein 1; Non-structural protein 1C
Species
Human respiratory syncytial virus B (strain 18537)
Expression Region
1-139
Target Protein Sequence
MGCNSLSMIK VRLQNLFDND EVALLKITCY TDKLILLTNA LAKAVIHTIK LNGIVFIHVI TSSEVCPDNN IVVKSNFTTM PILQNGGYIW ELIELTHCSQ SNGLMVDNCE IKFSKRLSDS VMTNYMNQIS DLLGLDLNS
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Plays a major role in antagonizing the type I IFN-mediated antiviral response by degrading or inhibiting multiple cellular factors required for either IFN induction or response pathways. Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3. Also disrupts the association of IRF3 with CREBBP. Interacts with host mitochondrial-associated membrane (MAM) MAVS and prevents the interaction with DDX58/RIG-I. Interacts with TRIM25 to suppress TRIM25-mediated DDX58 ubiquitination and thereby DDX58-MAVS interaction. Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and DDX58/RIG-I through a NS-degradasome involving CUL2 and Elongin-C. The degradasome requires an intact mitochondrial MAVS. Decreases the levels of host TRAF3 and IKBKE/IKK-epsilon. As functions other than disruptions of the type I IFN-mediated antiviral signaling pathways, induces host SOCS1 and SOCS3 expression. Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth. Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication. Suppresses proliferation and activation of host CD103+ CD8+ cytotoxic T-lymphocytes and Th17 helper T-lymphocytes.
Subcellular Location
Host cytoplasm. Host mitochondrion. Host nucleus.
Protein Families
Pneumovirus non-structural protein 1 family
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