Recombinant Monodelphis domestica Cyclin-dependent kinase inhibitor 2A(CDKN2A)

Product Type Recombinant Protein
Uniprot No. O77617
Species Monodelphis domestica (Gray short-tailed opossum)
Gene Names CDKN2A
Protein Names Recommended name: Cyclin-dependent kinase inhibitor 2A Alternative name(s): Cyclin-dependent kinase 4 inhibitor A Short name= CDK4I Tumor suppressor CDKN2A p16-INK4a Short name= p16-INK4
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity).
Subcellular Location Cytoplasm, Nucleus
Protein Families CDKN2 cyclin-dependent kinase inhibitor family
Tissue Specificity Expressed predominantly in lung and testis. In the testis, restricted to germ cells in the seminiferous epithelium. Not detected in premeiotic spermatogonia but high levels found in postmeiotic spermatids. In primary tumors, low levels detected in melanoc
Database Links

STRING: 13616.ENSMODP00000004687

UniGene: Mdm.219

Pathway p53 signaling pathway
Cell cycle
Cellular senescence

Product Details for Different Expression Systems

Product Name Recombinant Monodelphis domestica Cyclin-dependent kinase inhibitor 2A(CDKN2A),Yeast
Code CSB-YP005089MUE
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MGIVEKKEGG LERNRALFNS EGSCEGAKCG KEASMHTKHE SEESFSGEKL TEAAARGRTE VVTELLELGT NPNAVNRFGR SAIQVMMMGN VRLAAILLQY GAEPNTPDPT TLTLPVHDAA REGFLDTLML LHRAGARLDV RDSWGRLPVD LAEEQGHHLV VAYLREVVRD A
Expression Region 1-171
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Monodelphis domestica Cyclin-dependent kinase inhibitor 2A(CDKN2A),E.coli
Code CSB-EP005089MUE
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MGIVEKKEGG LERNRALFNS EGSCEGAKCG KEASMHTKHE SEESFSGEKL TEAAARGRTE VVTELLELGT NPNAVNRFGR SAIQVMMMGN VRLAAILLQY GAEPNTPDPT TLTLPVHDAA REGFLDTLML LHRAGARLDV RDSWGRLPVD LAEEQGHHLV VAYLREVVRD A
Expression Region 1-171
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Monodelphis domestica Cyclin-dependent kinase inhibitor 2A(CDKN2A),Baculovirus
Code CSB-BP005089MUE
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MGIVEKKEGG LERNRALFNS EGSCEGAKCG KEASMHTKHE SEESFSGEKL TEAAARGRTE VVTELLELGT NPNAVNRFGR SAIQVMMMGN VRLAAILLQY GAEPNTPDPT TLTLPVHDAA REGFLDTLML LHRAGARLDV RDSWGRLPVD LAEEQGHHLV VAYLREVVRD A
Expression Region 1-171
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Monodelphis domestica Cyclin-dependent kinase inhibitor 2A(CDKN2A),Mammalian cell
Code CSB-MP005089MUE
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MGIVEKKEGG LERNRALFNS EGSCEGAKCG KEASMHTKHE SEESFSGEKL TEAAARGRTE VVTELLELGT NPNAVNRFGR SAIQVMMMGN VRLAAILLQY GAEPNTPDPT TLTLPVHDAA REGFLDTLML LHRAGARLDV RDSWGRLPVD LAEEQGHHLV VAYLREVVRD A
Expression Region 1-171
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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