Recombinant Mouse 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Prkaa2)

1. AMPK mediates the progress of atrophy during unloading and regrowth of atrophied muscles following reloading, but it does not influence the transition of myosin heavy chain isoforms. PMID: 30262782
2. Those findings provide new insight into the mechanisms responsible for AMPKalpha2-dependent regulation of GLUT4 transcription after exercise. PMID: 28688716
3. data suggest that AMPK is an intermediate effector in endocannabinoid-mediated exercise-induced antinociception. PMID: 28479394
4. The rs2746342 polymorphism is significantly associated with susceptibility to type 2 diabetes mellitus (T2DM) and seems to interact with the rs2143754 polymorphism in the modulation of fasting plasma glucose (FPG) in the Han Chinese population. PMID: 27427333
5. AMPKalpha2 activation prevents cardiac hypertrophy predominantly by inhibiting O-GlcNAcylation. PMID: 29371602
6. Ampk is required for exercise-induced mitophagy in muscle. PMID: 28916822
7. This novel mechanism explains how CDK4 promotes anabolism by blocking catabolic processes (FAO) that are activated by AMPK. PMID: 29053957
8. High AMPKalpha2 phosphorylation is associated with abdominal aortic aneurysm. PMID: 28179583
9. TNF-alpha treatment of colonic rho(0) cells augmented IL-8 expression by 9-fold (P < 0.01) via NF-kappaB compared to TNF-alpha-treated control. Moreover, reduced mitochondrial function facilitated TNF-alpha-mediated NF-kappaB luciferase promoter activity as a result of lowered inhibitory IkappaBalpha (nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor, alpha), leading to elevated NF-kappaB. ... PMID: 28183804
10. Rac1 and AMPK together account for almost the entire ex vivo contraction response in muscle glucose transport, whereas only Rac1, but not alpha2 AMPK, regulates muscle glucose uptake during submaximal exercise in vivo. PMID: 28389470
11. we used the Cre-loxP system to knock down AMPKalpha2 expression in renal epithelial cells. Combining this approach with the systemic deletion of AMPKalpha1 we achieved reduced renal AMPK activity, accompanied by a shift to a moderate water- and salt-wasting phenotype. Thus we confirm the physiologically relevant role of AMPK in the kidney. PMID: 28179232
12. AMPK phosphorylation of cortactin followed by SIRT1 deacetylation modulates the interaction of cortactin and cortical-actin in response to shear stress. Functionally, this AMPK/SIRT1 coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase subcellular translocation/activation and is atheroprotective. PMID: 27758765
13. Findings show that decreased AMPK activity in muscle leads to decreased voluntary activity which is not due to secondary abnormalities in dopamine levels in the ventral striatum or sensitivity to cocaine. Thus, decreased voluntary activity in AMPK muscle deficient mice is most likely unrelated to regulation of brain dopamine content and metabolism. PMID: 27306083
14. Hypoxia reduces HNF4alpha/MODY1 protein expression in pancreatic beta-cells by activating AMP-activated protein kinase. PMID: 28364040
15. These studies reveal a novel mechanism in which CYP2J2 and epoxyeicosatrienoic acids enhanced Akt1 nuclear translocation through interaction with AMPKalpha2beta2gamma1 and protect against cardiac hypertrophy. PMID: 27416746
16. Loss of AMPKalpha2 is associated with impaired control of vesicular stomatitis virus infection. PMID: 27879319
17. AMPK-mediated HSPB1 expression enhanced insulin sensitivity in the skeletal muscle. PMID: 27928820
18. Collectively, our data support the notion that the activation of AMPKalpha2 contributes to the atrophic effects of denervation. PMID: 27136709
19. The activation of AMPKalpha2 in neutrophils is a decisive event in the initiation of vascular repair after ischemia. PMID: 27777247
20. AMPKalpha2 deletion induces vascular smooth muscle cell phenotype switching and promotes features of atherosclerotic plaque. PMID: 27439892
21. Suggest that E2 treatment ameliorates estrogen deficiency-induced changes in cardiac contractile function possibly through an AMPK-dependent mechanism. PMID: 25448287
22. AMPKalpha2 deletion and high-fat feeding adverse effects are not additive on heart function and myocardial ischemic tolerance. PMID: 26596312
23. AMPKalpha2 isoform plays a fundamental role in anti-oxidant stress and anti-senescence PMID: 26718972
24. AMPKalpha2 is involved in post-transcriptional and not transcriptional regulation of PDK4 in muscle. PMID: 26359931
25. PKD1 phosphorylates AMPKalpha2 at Ser485/491, thus diminishing AMPK activity. PMID: 26797128
26. In conclusion, our findings reveal a new functional role of activating AMPK in the CNS to attenuate inflammatory responses and acute lung injury in sepsis. PMID: 26252187
27. AMPKalpha signalling suppresses EMT and secretion of chemokines in renal tubular epithelia through interaction with CK2beta to attenuate renal injury. PMID: 26108355
28. the current data suggests that activation of AMPK signaling is sufficient but not required for exercise-induced accumulation in mitochondrial FAT/CD36. PMID: 25965390
29. The increase in nuclear PPARalpha protein by four-week exercise training under the intermittent hypoxia was dependent on AMPKalpha2 activation. PMID: 25923694
30. Low AMPK-alpha2 signaling disrupts, in part, the exercise training-induced adaptations. PMID: 25103967
31. provide evidence that high CO2 activates skeletal muscle atrophy via AMPKalpha2-FoxO3a-MuRF1, which is of biological and potentially clinical significance in patients with lung diseases and hypercapnia PMID: 25691571
32. AMPKalpha2 is an essential mediator of nicotine-induced whole-body IR in spite of reductions in adiposity PMID: 25799226
33. AMPKalpha2 ablation in muscle did not exacerbate high fat diet induce obesity in mice. On the contrary, it improved animal glucose tolerance and insulin sensitivity, with reduced triglyceride content in skeletal muscle. PMID: 25637528
34. AMPKalpha2 translocates into the nucleus via phosphorylation, AMPKalpha2 interacts with and phosphorylates hnRNP H in the nucleus, and such a protein-protein interaction modulates metformin-mediated glucose uptake. PMID: 24686086
35. activation of AMPKalpha2 seems crucial for maintaining skeletal muscle function, integrity and the ability to compensate chronic metabolic stress induced by SM mitochondrial uncoupling PMID: 24732703
36. Dietary wolfberry elevated the xanthophyll concentrations and enhanced expression of BCO2 and heat shock protein 60, activated AMPKalpha2, potentiated mitophagy and mitochondrial biogenesis and enhanced lipid oxidation and secretion in the liver of mice. PMID: 24449471
37. Data (including data from Prkaa2 knockout mice) suggest leptin is involved in regulation of cardiomyocyte contraction (or dysfunction) via Prkaa2 phosphorylation/activation and autophagy. PMID: 23688013
38. AMPK alpha2 might represent an important therapeutic target for colon cancer metastasis-induced liver injury PMID: 24515110
39. AMPKalpha2 significantly contributed to stabilization and activation of E2F1 by doxorubicin, forming a positive signal amplification loop. PMID: 24398673
40. Deletion of AMPKalpha2 causes aberrant VSMC migration with accelerated neointima formation via Skp2 up-regulation and E-cadherin down-regulation. PMID: 24115035
41. The impact of ageing and high fat diet on insulin action is not worsened in mice lacking functional alpha2AMPK in skeletal muscle. PMID: 23671593
42. AMPK is the first identified physiological substrate for CHIP chaperone activity, establishing a link between cardiac proteolytic and metabolic pathways. PMID: 23863712
43. A functionally active AMPKalpha2 subunit is required for insulin-stimulated muscle glycogen synthesis. PMID: 23224579
44. Suggest that AMPKalpha(2) is involved in the regulation of substrate uptake in a time-dependent manner in contracting muscle but is not necessary for regulation of fatty acid uptake and oxidation during caffeine treatment. PMID: 21551008
45. AMPKalpha2 controls cardiac p70S6K under normoxia and regulates eEF-2 but not the mTOR-p70S6K pathway during ischemia. PMID: 23466593
46. Data from knockout mice suggest that LKB1 (liver kinase B1) acts independent of AMPKa2 in regulation of oxidation of free fatty acids in skeletal muscle during physical activity/exercise. Knockdown of LKB1 leads to decrease in muscle AMPKa2. PMID: 23349504
47. AMPKalpha suppression or knockdown produces the opposite effects. The results demonstrate an anti-infamatory pathway linking AMPK, PARP-1, and Bcl-6 in endothelial cells PMID: 23382195
48. Our data identify the microtubule cytoskeleton as a sensitive target of AMPK activity, and the data suggest a novel role for AMPK in limiting accumulation and densification of microtubules that occurs in response to hypertrophic stress. PMID: 23316058
49. Endoplasmic reticulum stress increases vascular smooth muscle contractility resulting in high blood pressure, and AMP-activated protein kinase activation mitigates high blood pressure through the suppression of ER stress in vivo. PMID: 23288166
50. p70S6 kinase forms a complex with the alpha-2 catalytic subunit of AMPK, resulting in phosphorylation on serine(491). PMID: 22727014

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KEGG: mmu:108079

STRING: 10090.ENSMUSP00000030243

UniGene: Mm.48638