Recombinant Mouse Activin receptor type-2B (Acvr2b), partial

1. The current study reveals that ActRIIB activation by activin A induces muscle catabolism primarily through the activation of p38beta MAPK-mediated catabolic signalling that activates the ubiquitin-proteasome pathway and the autophagy-lysosome pathway. PMID: 27897407
2. The endoplasmic reticulum stress stress and unfolded protein response are increased in mdx muscle. However, these processes are not distinctly improved by voluntary exercise or blocking activin receptor IIB ligands and thus do not appear to be optimal therapeutic choices for improving proteostasis in Duchenne muscular dystrophy. PMID: 27554968
3. Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B-deficient mice exhibit no significant change in any bone parameter. PMID: 28659341
4. Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 PMID: 24726641
5. ActRIIB inhibition enhanced energy expenditure only at ambient temperature or in the cold, where nonshivering thermogenesis is minimal, suggesting that brown fat activation plays a prominent role in the metabolic actions of ActRIIB inhibition. PMID: 22586266
6. findings best fit a model in which BMP3, produced by mature bone cells, acts to reduce BMP signaling through Acvr2b in skeletal progenitor cells, limiting their differentiation to mature osteoblasts PMID: 22074949
7. Functional redundancy in osteoblast differentiation is observed between bone morphogenetic protein receptor BMPR-II and ActR-IIB. PMID: 21503889
8. Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice. PMID: 21281811
9. Akt isoforms are not essential for for the ability of ActRIIB inhibition to regulate muscle size and function . PMID: 20856813
10. ActRIIB plays a role in the specification of left-sidedness in developing mice PMID: 12112458
11. Activin type IIB(ActRIIB) and its subfamily receptor, Activin type IIA (ActRIIA), cooperatively mediate the Gdf11 signal in patterning the axial vertebrae PMID: 12414726
12. ActRIIB is expressed in the early development of thymocytes. PMID: 16477644
13. genetic evidence strongly suggested that ActRIIB and Smad2 function in the same signaling pathway to regulate axial patterning and pancreas islet formation by means of a threshold mechanism. PMID: 17849440
14. expression of MSTN and its associated binding proteins can be modulated in adipose tissue and skeletal muscle by chronic obesity PMID: 18334608
15. Data suggest that BMP3 exerts its effects in the skeleton by altering signaling through ActRIIB in chondrocytes and the periosteum, and this results in defects in bone collar formation and late hypertrophic chondrocyte maturation. PMID: 19653325

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KEGG: mmu:11481

STRING: 10090.ENSMUSP00000126108

UniGene: Mm.390239