Recombinant Mouse Alpha-1-antitrypsin 1-1 (Serpina1a)

Code CSB-YP357195MO
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP357195MO
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP357195MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP357195MO
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP357195MO
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
Serpina1a
Uniprot No.
Alternative Names
Serpina1a; Dom1; Spi1-1Alpha-1-antitrypsin 1-1; AAT; Alpha-1 protease inhibitor 1; Alpha-1-antiproteinase; Serine protease inhibitor 1-1; Serine protease inhibitor A1a; Serpin A1a
Species
Mus musculus (Mouse)
Expression Region
25-413
Target Protein Sequence
EDVQET DTSQKDQSPA SHEIATNLGD FAISLYRELV HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF NLTQTSEADI HKSFQHLLQT LNRPDSELQL STGNGLFVNN DLKLVEKFLE EAKNHYQAEV FSVNFAESEE AKKVINDFVE KGTQGKIAEA VKKLDQDTVF ALANYILFKG KWKKPFDPEN TEEAEFHVDE STTVKVPMMT LSGMLHVHHC STLSSWVLLM DYAGNATAVF LLPDDGKMQH LEQTLSKELI SKFLLNRRRR LAQIHFPRLS ISGEYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSQ AVHKAVLTID ETGTEAAAVT VLQMVPMSMP PILRFDHPFL FIIFEEHTQS PIFLGKVVDP THK
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
Gene References into Functions
  1. Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation. PMID: 27515817
  2. this study proved that SYVN1 enhances SERPINA1(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1(E342K)/ATZ cytotoxicity. PMID: 28121484
  3. hAAT inhibits DC activation and function, and it also attenuates autoimmunity and renal damage in the MRL/lpr lupus model PMID: 27232337
  4. FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy. PMID: 26295339
  5. Data indicate that the scFv4B12 intrabody increased the secretion of Z alpha1-antitrypsin that retained inhibitory activity against neutrophil elastase. PMID: 25757566
  6. unchecked neutrophil serine protease activity may arise from F. tularensis targeted reduction of plasma alpha(1)-antitrysin promoting lung tissue damage facilitating increased dissemination of this bacterium in infection PMID: 22919586
  7. alpha-1 antitrypsin gene induction has a role in experimental and clinical acute kidney injury PMID: 24848503
  8. A1AT bidirectional uptake and secretion from lung endothelial cells towards the alveolar epithelium and airspaces PMID: 24743137
  9. oxidative stress is a contributing factor in the development of liver disease in this model of alpha-1-antitrypsin deficiency. PMID: 23104507
  10. Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival PMID: 22949661
  11. Data sshow that that plasmid-derived circulating hAAT protects islet allografts from acute rejection. PMID: 21670848
  12. AAT represents a novel and viable strategy to mitigate clinical graft-versus-host disease by reducing serum levels of proinflammatory cytokines and altering the ratio of donor T effector to T regulatory cells in favor of reducing the pathological process. PMID: 22203983
  13. Serpina1a serves a critical, nonredundant function during early mouse development. PMID: 21574874
  14. analysis of the effect of mutant alpha1-antitrypsin on alpha1-antitrypsin deficiency PMID: 21505264
  15. IL-8-induced hematopoietic stem cell mobilization is inhibited by serpina1 PMID: 16432201
  16. Regulator of G Signaling 16 has a role in the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency PMID: 17635928

Show More

Hide All

Subcellular Location
Secreted.
Protein Families
Serpin family
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1