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Recombinant Mouse Alpha-hemoglobin-stabilizing protein (Ahsp)

Recombinant Mouse Alpha-hemoglobin-stabilizing protein (Ahsp)

Code	CSB-YP875156MO
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP875156MO
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP875156MO-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP875156MO
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP875156MO
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ahsp

Uniprot No.

Q9CY02

Alternative Names

Ahsp; Edrf; ErafAlpha-hemoglobin-stabilizing protein; Erythroid differentiation-related factor; Erythroid-associated factor

Species

Mus musculus (Mouse)

Expression Region

1-102

Target Protein Sequence

MAPFQSNKDL ISTGIKEFNV LLDQQVFDDP LISEEDMVIV VHDWVNLYTN YYKKLVHGEQ EEQDRAMTEF QQELSTLGSQ FLAKYRTFLK SKEPPSNTLP SS

Protein Length

full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation.

Gene References into Functions

role of alpha-hemoglobin stabilizing protein in hemoglobin assembly PMID: 22287545
Endogenous AHSP is not limiting for alpha-globin detoxification in beta-thalassemic mice. PMID: 20815047
An abundant erythroid protein that stabilizes free alpha-haemoglobin. PMID: 12066189
activin A does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh-dependent mechanism PMID: 15054113
Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia. PMID: 15545996
These results support the hypothesis that EKLF acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin genes and indicate that EKLF may play similar roles for other erythroid genes. PMID: 16705186
developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF might be one of the steps necessary for the switch-on of the mammalian adult beta globin gene transcription PMID: 17242208
AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly PMID: 17607360
The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein on the cell surface is reported. PMID: 18828445