Recombinant Mouse Aryl hydrocarbon receptor (Ahr), partial

1. Distribution of parent PCB congeners also varied by genotype with strikingly high levels of PCB 77 in poor-affinity Ahr (d) Cyp1a2(-/-) while Ahr (b) Cyp1a2(+/+) mice effectively sequestered coplanar PCBs in the liver. PMID: 29197979
2. these data support a prominent role for the AhR in regulating lung miRNA expression. PMID: 28079158
3. In air-exposed airway epithelia, induction of factors required for multiciliogenesis, including cyclin O (Ccno) and Multicilin (Mcidas), is AhR dependent, and air exposure induces AhR binding to the Ccno promoter. Submersion and hypoxic conditions impede AhR-dependent Ccno induction. PMID: 27554288
4. Shared epitope-aryl hydrocarbon receptor crosstalk underlies the mechanism of gene-environment interaction in autoimmune arthritis. PMID: 29666259
5. airway inflammatory cells and cytokines present in BALF and TRIF in lung tissue play a role in inducing AHR and airway inflammation upon RSV and bacteria coinfection PMID: 28695368
6. Ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD. PMID: 29107595
7. AhR activation ameliorated epithelial barrier dysfunction following intestinal ischemia/reperfusion and hypoxia through upregulation of Notch1 signaling. PMID: 29286081
8. Low AHR expression is associated with provokes locomotor defects and alteration of myelin structure. PMID: 29351992
9. Data indicate aryl hydrocarbon receptor (AhR) and small heterodimer partner (SHP) as new physiological regulators of phosphatidylcholines (PC) and S-adenosylmethionine (SAM) levels. PMID: 29416063
10. These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSSinduced colitis via the MK2/pMK2/TTP pathway. PMID: 29207040
11. These results validate the role of the AhR pathway in regulating choroidal neovascular pathogenesis, identify mechanisms of AhR-based therapies in the eye, and argue in favor of developing AhR as a drug target for the treatment of neovascular AMD. PMID: 29481912
12. Deletion of the Ahr gene in cardiomyocytes protects males from heart dysfunction due to NKX2.5 haploinsufficiency. PMID: 28973413
13. Identify Cxcl5 as a novel target of AHR-mediated gene expression in primary mouse keratinocytes. PMID: 28973351
14. this study shows that tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia PMID: 28098246
15. Ambient particulate matter enhances dendritic cell activation that primes naive T cell differentiation towards a Th17-like phenotype in an AhR-dependent manner. PMID: 29689377
16. AHR role in the acute lethal pulmonary inflammation PMID: 28673995
17. These findings highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli. Specifically, AhRR contributes to the maintenance of colonic intraepithelial lymphocytes and prevents excessive IL-1beta production and Th17/Tc17 differentiation. In contrast, the AhRR enhances IFN-gamma-production by effector T cells in the in... PMID: 27184933
18. these data support that RelB suppresses cigarette smoke-induced apoptosis, potentially by increasing the AhR PMID: 28254546
19. Results elucidate the dimerization process of AhR with ARNT and propose the structure of the N-terminal region of the AhR:ARNT dimer including the bHLH, PAS-A and PAS-B domains. PMID: 28393157
20. the AhR pathway is much more that a xenobiotic metabolism-inducing pathway, and the regulation by AhR of Notch signaling in the testis offers some insight into the mechanism of infertility in men. PMID: 27688768
21. UV and environmental stimulation of melanoblast-to-melanocyte maturation are enhanced via the AHR pathway. PMID: 27539901
22. the expression of CDC42 might be regulated by AHR, and both proteins are fundamental to the development of normal spermatozoa and the acrosome reaction. PMID: 27635527
23. study provides supportive evidence of the integration of AhR with circadian rhythms and metabolism, where its activation under homeostatic conditions influences circadian rhythm amplitude PMID: 28347186
24. the untimely expression of the Ahr gene needs to be repressed to maintain embryonic stem cell mitotic progression and prevent premature loss of pluripotency. PMID: 27374890
25. These results establish that mo-DCs and mo-Macs are controlled by distinct transcription factors and show that AHR acts as a molecular switch for monocyte fate specification in response to micro-environmental factors. PMID: 28930664
26. The results suggest AhR activation causes the loss of liver-specific and sexually dimorphic gene expression producing a functionally "de-differentiated" hepatic phenotype. PMID: 28922406
27. Study provides evidence supporting the importance of AHR in tumor progression and host survival through the upregulation of ISX expression and promotion of tumor cell growth while restraining the expression of tumor suppressors in hepatocellular carcinoma (HCC), and thereby suggests a plausible mechanistic link between AHR and HCC. PMID: 28398627
28. AhR controls COX-2 protein via mRNA stability. PMID: 28749959
29. functional AhR expression is critical for skin barrier integrity and that AhR represents a molecular target for the development of therapeutic approaches for skin barrier diseases, including by dietary intervention. PMID: 27430407
30. Lipopolysaccharide (LPS) stimulation increased the expression and activity of the immunoregulatory enzyme IDO1 in hepatic stellate cells (HSCs), and LPS/HSCs stimulated aryl hydrocarbon receptor (AhR) signaling in cocultured regulatory T cells. PMID: 27581538
31. Donor T cells lacking AhR demonstrate decreased acute graft versus host disease because of reduced donor T-cell proliferation early after transplant. PMID: 28550042
32. this study shows that AhR-/- mice display impaired bone healing with delayed endochondral ossification PMID: 27849171
33. AhR(-/-) mice are not able to mount an Natural killer cell memory response to hapten rechallenge. PMID: 27670593
34. Hyperhomocysteinemia activates the AHR-CD36 pathway by increasing hepatic LXA4 content, which results in hepatic steatosis. PMID: 26928949
35. data indicate that intestinal epithelial cells serve as gatekeepers for the supply of AHR ligands to the host and emphasize the importance of feedback control in modulating AHR pathway activation PMID: 28146477
36. Here, the authors report that Candida albicans infection activates the aryl hydrocarbon receptor (AhR), leading to activation of Src family kinases (SFKs), which in turn phosphorylate EGFR and induce endocytosis of the fungus. PMID: 28325761
37. AhR-deficient (Ahr(-/-)) B cells proliferate less than AhR-sufficient (Ahr(+/+)) cells following in vitro B-cell receptor stimulation and in vivo adoptive transfer models confirmed that Ahr(-/-) B cells are outcompeted by Ahr(+/+) cells. PMID: 27875245
38. AhR has a direct role in IL-22 production by Th17 cells in the mouse ear skin, but not by gammadelta T cells, CD4(-) CD8(-) TCRbeta(+) T cells and ILCs. PMID: 27000947
39. The inverse correlation between Smad7 and AhR expression helps to propagate inflammatory signals in the gut in Crohn's disease. PMID: 26818761
40. Findings suggest that miR-124 induces intestinal inflammation by inhibiting AHR to modulate pro-inflammatory cytokine production and thereby promotes the pathogenesis of Crohn's disease. PMID: 26802080
41. STAT3 may cooperate with AhR to regulate the differentiation of both Th17 and Treg cells PMID: 28445259
42. this study reveals the physiological importance of endogenous activation of AHR signaling in shaping the IFN-I-mediated innate response PMID: 27089381
43. AhR is associated with tumor prevention by regulating gut immunity, whereas in tumor cells, it is involved in growth suppression. PMID: 26973338
44. The co-treatment with gamma-T3 and baicalein enhanced the anti-proliferative activity of baicalein, accompanied by the downstream events of AhR-activation induced by baicalein. These data suggest that gamma-T3 upregulates AhR expression and enhances its sensitivity to baicalein. PMID: 27055589
45. Study elucidates that AhR plays an important role in mesangial cells activation, macrophage infiltration, and extracellular matrix accumulation in diabetic nephropathy conferred by oxidative stress. PMID: 26415004
46. data show that AHR contributes to hepatic energy homeostasis, partly through the regulation of FGF21 expression and signaling. PMID: 27226639
47. Indoleamine 2,3-dioxygenase 1 inhibitors can activate the aryl hydrocarbon receptor. PMID: 28336214
48. AhR expression is dependent on NFATc1 activation, and NFATc1 inhibition remarkably decreases AhR expression in mouse lung tissue. CsA administration resulted in a significant reduction of AhR expression. PMID: 27353300
49. this study shows that benzopyrene exposure increases Langerhans cell migration, and increases IL-5, IL-13, and IL-17 levels following atopic sensitization; the increased cytokine levels are attenuated in AhR knock-out mice PMID: 27129092
50. Disruption of the Ahr gene alters macrophage polarization when compared to WT macrophage PMID: 27153778

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KEGG: mmu:11622

STRING: 10090.ENSMUSP00000112137

UniGene: Mm.341377