Recombinant Mouse B-cell receptor CD22 (Cd22), partial

1. Thus, proximity labeling with tyramide appears to be a useful method to identify cis-ligands and to analyze their interaction with the lectins. PMID: 29146181
2. This combined approach suggests that the inhibitory function of CD22 is influenced by its nanoscale organization and is ensured by its fast diffusion enabling a "global BCR surveillance" at the plasma membrane. PMID: 26671981
3. results demonstrate that loss of high affinity CD22 ligands on GC B-cells occurs in both mice and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells PMID: 26507663
4. A noncatalytic role for CD45 in regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR) signaling through modulation of the function of the inhibitory coreceptor CD22, was identified. PMID: 26561584
5. CD22 is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge. PMID: 25252961
6. These data assign a key role to CCL22 in Treg recruitment in the protection of NOD mice against type 1 diabetes following the treatment with G-CSF. PMID: 23878314
7. Thus, CD22 plays an essential role in controlling West Nile virus infection by governing cell migration and CD8(+) T cell responses. PMID: 23302871
8. that neither B cells nor CD22 are critical for the immediate antiinflammatory activity of IVIgs in mouse models of rheumatoid arthritis and ITP. PMID: 22945870
9. Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia. PMID: 22930244
10. novel expression pattern and tissue eosinophilia-regulating function for the "B cell-specific" inhibitory molecule CD22 on GI eosinophils. PMID: 22190185
11. As a receptor for sIgM, CD22 induces a negative feedback loop for B-cell activation/ PMID: 21956693
12. The efficacy of a ligand-targeting approach to B cell-specific depletion therapy for cancer may be the ability of CD22 to recycle and accumulate ligand-decorated cargo intracellularly, as an endocytic receptor. PMID: 21178016
13. It regulates B lymphocyte signaling. (review) PMID: 21089380
14. CD22 and BLyS promote the survival of overlapping B-cell subsets but contribute to their maintenance through independent and complementary signaling pathways PMID: 20513733
15. CD22 deficiency results in prolonged contact hypersensitivity (CHS) reactions and suggests an inhibitory role for CD22 expression, especially during the late phase in elicitation of CHS. PMID: 20335532
16. Siglec-G and CD22 have partly compensatory functions and together are crucial in maintaining the B cell tolerance. PMID: 20200274
17. Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. PMID: 20038598
18. Data show that anti-CD22 autoantibodies were positive in 80% of TSK/+ mice and in 22% of SSc patients. PMID: 19919568
19. The Lyn/CD22/SHP-1 pathway is important in autoimmunity. Naive and tolerant B-cells differ in their calcium signaling in response to antigenic stimulation. PMID: 11826756
20. sialic acid binding domains are necessary for CD22 to function as a negative regulator PMID: 11994425
21. The expression and function of CD22 are differentially regulated in B-1 and conventional B-2 lymphocytes, which are implicated in innate and adaptive immunity, respectively. PMID: 12055217
22. CD22 binding to native CD45 and synthetic oligosaccharide PMID: 12115612
23. Surface expression of CD22 is selectively increased on B lineage cells in the bone marrow of BOB.1/OBF.1-deficient mice AND regulates early B cell development. PMID: 12207332
24. In the yeast two-hybrid system the carboxyl-terminal portion of the CD22 cytoplasmic tail, encompassing tyrosine residues 843 and 863, is critical for binding of clathrin adaptor AP50 to CD22, an interaction required for internalization. PMID: 12646615
25. Inhibitory coreceptors CD22 and CD72 are responsible for setting the requirement of CD40 signaling for survival and proliferation of antigen-stimulated spleen B cells. PMID: 12902484
26. CD22 is an inhibitory coreceptor for B cell receptor (BCR) signaling. The inhibition is most likely mediated by activation of SHP-1. PMID: 14635051
27. CD22 neither associates with nor functions in major histocompatibility complex (MHC) class II/Ig-alpha beta signaling, and is actively excluded from cell surface MHC class II aggregates. PMID: 14688326
28. CD22 is defined as a critical regulator of B cell proliferation, survival, phenotype, and the expression of essential cell cycle regulatory genes, especially in the context of a C57BL/6 genetic background. PMID: 14764675
29. reduced Marginal Zone B cell compartment in the absence of CD22 expression does not interfere with the inflammatory response during S. aureus arthritis and sepsis. PMID: 15050965
30. Neurons secrete CD22, which functions as an inhibitor of microglial proinflammatory cytokine production. PMID: 15095367
31. Results suggest that CD22 is expressed on mouse primary T cells and capable of associating with the Src homology 2 domain-containing protein-tyrosine phosphatase, SHP-1. PMID: 15364920
32. CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. PMID: 15378059
33. knock-out mice have increased numbers of B-1 cells, BCR signalling hyperesponsiveness, develop autoimmune disease-like manifestations, genetic polymorphisms may contribute to autoimmunity PMID: 16227086
34. deficiencies in both CD22 and its ligand (Cd22-/- St6gal1-/- mice) showed restored B cell receptor (BCR) signaling, suggesting that the suppressed signaling of St6gal1-/- cells is mediated through CD22 PMID: 16369536
35. negative role of CD22 in CD40 signaling PMID: 16393971
36. Protein glycosylation by ST6Gal-I restricts access of antigen receptors and Shp-1 to CD22 and operates by a CD22-dependent mechanism. PMID: 16782884
37. inhibition of CD22 ligand binding can disrupt normal and malignant B cell survival in vivo and suggest a novel mechanism of action for therapeutics targeting CD22 ligand binding domains PMID: 16920943
38. gamma1 chain can exert a unique signaling function that can partially replace that of the Ig alpha/beta heterodimer in B cell maintenance and may contribute to memory B cell physiology PMID: 17420268
39. strongly suggest that synthetic glycan ligand excludes CD22 from BCR-containing lipid rafts PMID: 17631277
40. These immunoreceptor tyrosine-based inhibition motifs constitute a novel conditional SHP-1-binding site of CD22 that is activated upon BCR ligation by antigen but not by anti-Ig Ab. PMID: 18024433
41. B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. PMID: 18178830
42. second CD22 ligand (CD22L) is expressed on CD11c(+) splenic and bone marrow-derived dendritic cells PMID: 18354178
43. SAP is expressed endogenously in mouse splenic B cells and co-localizes and interacts with CD22. SAP binding to the inhibitory immunoreceptor CD22 regulates calcium mobilization in B cells. PMID: 19150402
44. Inhibition of B cell receptor signaling by Lyn kinase-CD22-Src homology region 2 domain-containing phosphatase-1 (SHP-1) pathway is up-regulated as splenic B cells mature, and is involved in maintenance of peripheral B-cell immune tolerance. PMID: 19380785

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KEGG: mmu:12483

STRING: 10090.ENSMUSP00000019248

UniGene: Mm.260994