Recombinant Mouse Bloom syndrome protein homolog (Blm), partial

1. In the absence of BLM, sister chromatid exchange events do not occur randomly throughout the genome but are strikingly enriched at coding regions, specifically at sites of guanine quadruplex motifs in transcribed genes. PMID: 29348659
2. The anti-recombinase activity of BLM is of general importance for normal retention of RAD51 at DNA double strand break sites and regulation of homologous recombination. PMID: 28912125
3. BLM helicase facilites telomere replication by resolving G4 structures formed during copying of the G-rich strand by leading strand synthesis. PMID: 26195664
4. Data suggest that BLM suppresses homologous recombination, while full-length BRCA1 promotes this process. PMID: 21709021
5. Although interhomolog recombination is slightly decreased in the absence of BLM, loss of heterozygosity is increased by fivefold or more, implying significantly increased interhomolog crossing over. PMID: 21730139
6. Blm has roles both upstream and downstream of the Rad54 protein, a core HR factor. Disruption of Rad54 in the Blm-mutant background reduced the elevated level of gene targeting and of sister chromatid exchanges. PMID: 20531307
7. the characterization of Hprt mutations in vivo in Blm hypomorphic mice PMID: 20299287
8. there was no dramatic qualititative difference in the basal cell carcionoma or rhabdomyosarcoma tumors associated with the mutant Blm genotype PMID: 19995795
9. Data show that BLM-deficient mouse and human cells suppress homeologous recombination to a similar extent as wild-type cells. PMID: 20154148
10. observations indicate that Blm is a modifier of tumor formation in the mouse and that Blm haploinsufficiency is associated with tumor predisposition PMID: 12242442
11. Bone marrow cells from mice heterozygous for BLM mutation, BLM(Cin/+), transfected with BCR/ABL display increased sensitivity to cisplatin. PMID: 15750625
12. Blm gene mutation produces this instability, strengthening a role for CIN in the development of human cancer. PMID: 16914751
13. Blm serves a vital role for development, maintenance, and function of T lymphocytes, suggesting a basis for the immune deficiency in Bloom's syndrome. PMID: 17210642
14. BLM, the RecQ DNA helicase mutated in Bloom syndrome, is preferentially modified by SUMO-2/3 both in vitro and in vivo PMID: 18708356
15. A vital role is reported for RecQ family helicase Blm in all major aspects of the B cell life cycle, manifest in disturbed B cell immunity and tumor development in its absence. PMID: 19109166
16. The sister chromatid exchange events stimulated by Tim reduction were largely mediated via a Brca2/Rad51-dependent mechanism and were additively increased by deletion of the Blm helicase. PMID: 19112184

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KEGG: mmu:12144

STRING: 10090.ENSMUSP00000127995

UniGene: Mm.12932