Recombinant Mouse Breakpoint cluster region protein (Bcr), partial

1. BCR signaling elicits maximal cell death through upregulation of multiple BH3-only proteins; namely Bim, Bik, and Noxa. PMID: 26184912
2. The resistance in BCR-ABL1 cells resulted either from the Y253H mutation in the BCR-ABL1 gene or incubation in increasing concentrations of imatinib. PMID: 26251899
3. PDZK1 has novel SR-BI-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 suppression of VSM cell proliferation via an inhibitory interaction with Bcr PMID: 25886360
4. Hap1 interacts with Bcr on microtubules to regulate neuronal differentiation. PMID: 25671650
5. Grb10 is involved in BCR-ABL-positive leukemia in mice. PMID: 25249015
6. Bcr is an integral member of the Par-Tiam1 complex that controls polarized cell migration by locally restricting both Rac1 and PKCzeta function. PMID: 24152735
7. Loss of Bcr expression causes defects in spine development. PMID: 24960694
8. Suggest that HS-438 may be a novel drug candidate with the therapeutic potential to target BCR-ABL and overcome imatinib resistance in patients with chronic myeloid leukemia. PMID: 24657654
9. IRF8-rescued BCR-ABL-expressing dendritic cells were capable of inducing CTLs more efficiently than control dendritic cells. PMID: 24242069
10. study provided evidence for a novel, BCR-ABL-mediated antiapoptotic mechanism, which results from the increased acetylation of p53 at the K317/K320 residue, thus preventing the nuclear export of p53 in response to DNA damage. PMID: 22696202
11. Intrafemoral transplantation of BCR-ABL-transduced Cbl-b(-/-) cells revealed equivalent latency of disease development to the wild-type transplants PMID: 23160449
12. Data show that T315I-mutated BCR-ABL is functional at the stem cell level, conferring to murine embryonic stem cell (mESC)-derived leukemic cells a long-term hematopoietic repopulation ability. PMID: 23287417
13. BCR is a novel substrate of PTPRT . PMID: 22767509
14. BCR signalling as a mechanism to cause biased cellular and Ig repertoire selection, ultimately contributing to B cell-mediated autoimmune predisposition. PMID: 22728826
15. Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice. PMID: 22408137
16. BCR-JAK2 codes for a protein containing the BCR oligomerization domain fused to the JAK2 tyrosine-kinase domain PMID: 22384256
17. STAT5a/b is essential for the induction of CML-like leukemia by BCR-ABL1 and of polycythemia by JAK2(V617F). PMID: 22234689
18. The data confirm that BCR-ABL promotes ROS and demonstrate that NF-kappaB prevents excessive levels. PMID: 21625221
19. CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis PMID: 21900237
20. Study shows that an intramolecular interaction between the SH2 and kinase domains in Bcr-Abl is both necessary and sufficient for high catalytic activity of the enzyme. PMID: 22000011
21. (18)F-SKI696 is taken up in vivo by tumors that overexpress Bcr-Abl PMID: 21764785
22. Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia. PMID: 21263154
23. The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.[Bcr-Abl] PMID: 18813851
24. Id2 deficient mice in a C57BL/6 genetic background exhibit increased cellularity in the granulocyte/myeloid progenitor compartment and show significantly higher numbers of maturing neutrophils.[Bcr-Abl] PMID: 18725623
25. BCR-mediated regulation of recombination-activating gene expression is additively controlled in B cells by the extracellular signal-regulated MAP kinase and phosphatidylinositol 3-kinase pathways, in ligand-dependent and ligand-independent manners. PMID: 20709952
26. a BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice PMID: 19823681
27. A mouse model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 PMID: 12032333
28. These findings suggest that Bim plays an important role in the apoptosis of early hematopoietic progenitors and that Bcr-Abl supports cell survival in part through downregulation of this cell death activator. PMID: 15226421
29. suppression of normal hematopoiesis in BCR-ABL-induced leukemia is an active process involving secretion of the cell death-inducing factor 24p3 by mouse leukemia cells PMID: 15735695
30. in mature B cells, BCR stimulation induces a short lived unfolded protein response similar to the LPS-triggered nonclassical UPR, but does not induce plasma cell differentiation PMID: 16188879
31. BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells PMID: 16297667
32. BCR-ABL-expressing leukemic stem cells depend to a greater extent on CD44 for homing and engraftment than do normal hematopoietic stem cells PMID: 16998483
33. Coexpression with the bcr-1 isoform of PML-RARalpha did not increase the penetrance of APL The bcr-1 and bcr-3 isoforms of RARalpha-PML, therefore, have different biological activities that may be relevant for the pathogenesis of murine APL. PMID: 17008533
34. BCR/ABL repressed CCL9 expression at the transcriptional level PMID: 17160016
35. Bcr-Abl oncoprotein requires the IL-3 receptor/Jak2/Stat5 pathways for oncogenic transformation of NIH 3T3 fibroblasts. PMID: 18071309
36. cells treatment-induced BCR-ABL mutations conferring broad resistance to kinase inhibitor were able to spread resistance to non-mutated cells through overexpression of interleukin 3, activation of MEK/ERK and JAK2/STAT5 pathways, and downregulation of Bim PMID: 18216868
37. BCR-ABL impairs host defenses and promotes malignant transformation, involving dual suppression of IFN-activated signaling pathways PMID: 18287094
38. The interaction of beta1-integrin and extracellular matrix components is functionally important in leukemic cells expressing high-levels of BCR/ABL. PMID: 18313694
39. T315I mutant form of BCR-ABL is associated with leukemia PMID: 18429956
40. Expression of miR-203 reduces ABL1 and BCR-ABL1 fusion protein levels and inhibits tumor cell proliferation in an ABL1-dependent manner, suggesting it may function as a tumor suppressor. PMID: 18538733
41. BCR-ABL leukemogenesis inis blocked by PI3K in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells PMID: 18704194
42. FcgammaRIIB coaggregation dampens BCR-induced BLyS receptor up-regulation PMID: 18791164
43. Intimal proliferation in low-flow carotid arteries is decreased in Bcr knockout mice compared with wild-type mice, suggesting the critical role of Bcr kinase in VSMC proliferation in vivo, by regulating PPARgamma/nuclear factor kappaB. PMID: 19023129
44. BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair PMID: 19571320

Show More

Hide All

KEGG: mmu:110279

STRING: 10090.ENSMUSP00000126377

UniGene: Mm.333722