Recombinant Mouse CCAAT/enhancer-binding protein beta (Cebpb)

1. findings support that C/EBPbeta plays a pivotal role in AD pathogenesis via increasing delta-secretase expression PMID: 29725016
2. LCoR negatively regulates early adipogenesis by repressing C/EBP beta transcriptional activity and add LCoR to the growing list of transcriptional corepressors of adipogenesis. PMID: 28972158
3. results support a stimulatory effect of Pb on adipogenesis which involves ERK activation and C/EBPbeta upregulation prior to PPARgamma and adipogenesis activation. PMID: 28646352
4. Purple sweet potato colour, a class of naturally occurring anthocyanins, exhibited beneficial effects on hepatic steatosis, which were associated with blocking Src and C/EBPbeta activation. PMID: 28636830
5. Thus, this study identifies BCL11B as a novel regulator of adipogenesis, which works, at least in part, by stimulating C/EBPbeta activity and suppressing the Wnt/beta-catenin signaling pathway. PMID: 27586877
6. Study shows that alpha melanocyte stimulating hormone and forkhead box C2 protein promote fatty acid oxidation through C/EBPbeta negative transcription in mice adipose tissue. PMID: 27819350
7. The results indicated that miR-16 was transactivated by C/EBP-beta resulting in aggravated Ischemia-reperfusion induced acute kidney injury and that urinary miR-16 may serve as a potential biomarker for acute kidney injury. PMID: 27297958
8. These results suggest that C/EBPbeta is an endogenous initiator of neuropathic pain and could be a potential target for the prevention and treatment of this disorder. PMID: 28698219
9. We found that C/EBPbeta is phosphorylated by CK2 under AMPK suppression and ER stress, which are important from the viewpoint of the worsening pathological condition of type 2 diabetes, such as decreased insulin secretion and apoptosis of pancreatic beta cells. PMID: 29448105
10. Expression of the SENP2 gene was suppressed by theobromine. In vivo knockdown studies showed that AR1 knockdown in mice attenuated the anti-adipogenic effects of theobromine in younger mice. Theobromine suppresses adipocyte differentiation and induced C/EBPbeta degradation by increasing its sumoylation. PMID: 28965824
11. C/EBPbeta is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2. PMID: 27923399
12. These data establish C/EBPbeta as a key driver of autoimmune inflammation in EAE, and propose a novel role for C/EBPbeta in regulation of IL-23R expression. PMID: 28088614
13. C/EBPbeta in hematopoietic cells is crucial to regulate diet-induced inflammation, hyperlipidemia and atherosclerosis development PMID: 27072340
14. C/EBPbeta or Stat3 depletion by siRNA in sepsis Gr1(+)CD11b(+) MDSCs inhibits miR-21 and miR-181b expression. PMID: 27430527
15. The present study indicates a requirement for C/EBPbeta in the insulin-mediated induction of SREBP-1c mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha, our data reported herein indicate a requirement for both transcription factors. PMID: 27382175
16. elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase/activator protein 1 pathway (MAPK/AP-1). PMID: 28383550
17. Ptn may play a vital role in the progesterone-induced decidualization pathway via C/EBPB-cyclic AMP-Hand2 signaling. PMID: 28657144
18. C/EBPbeta is a critical factor for Ly6C(-) monocyte survival, at least in part through upregulation of Csf1r. PMID: 28807982
19. these results support that decreasing C/EBPbeta expression prevents MDSC generation and decreases immunosuppression in septic mice, providing a target for sepsis treatment. PMID: 28934717
20. PARP-1 attenuates adipogenesis by PARylating C/EBPb, a pro-adipogenic transcription factor, on three residues in its regulatory domain. PMID: 28107648
21. Results show that C/EBPbeta and C/EBPdelta actively regulate the promotor region of both splicing variants Ppargamma1sv and Ppargamma2 in mouse adipocytes. PMID: 23840343
22. These results show that C/EBPbeta directs a switch from proinflammatory to repressor myeloid cells PMID: 28476751
23. Both gain- and loss-of-function studies showed that an accumulation of the CCAAT/enhancer binding protein-beta (C/EBP-beta) protein, which cooperates with dominant transcriptional co-regulator PR domain containing 16 (PRDM16) to determine brown/beige adipocyte lineage, is essential for the enhanced adipocyte browning caused by the loss of ZIP13 PMID: 28854265
24. monocyte differentiation occurred through de novo enhancer establishment and activation of pre-established (poised) enhancers. Generation of Ly6C(-) monocytes involved induction of the transcription factor C/EBPbeta and C/EBPbeta-deficient mice lacked Ly6C(-) monocytes. PMID: 28514690
25. Intra-tumor IL-6, C/EBP-beta and PPAR-gamma expression correlated with intramuscular liposarcoma growth in mice and autophagy. PMID: 28668397
26. these findings highlight a critical role of TSC1 in regulating innate immunity by control of the mTOR1-C/EBPbeta pathway. PMID: 27593484
27. Expression of miR-26a or knockdown of Klf4 or Creb or C/ebpbeta, attenuated the survival of Mycobacterium tuberculosis in macrophages. PMID: 28558034
28. Valproic acid attenuated muscle wasting and myotube atrophy and reduced C/EBPbeta binding to atrogin1 promoter locus in the myotubes. PMID: 27122162
29. work shows that helenalin acetate inhibits C/EBPbeta by binding to the N-terminal part of C/EBPbeta, thereby disrupting the cooperation of C/EBPbeta with the co-activator p300. PMID: 27803164
30. SatM (ceacam1(+)Msr1(+)Ly6C(-)F4/80(-)Mac1(+) monocytes, called "segregated-nucleus-containing atypical monocytes") are critical for fibrosis and C/EBPbeta licenses differentiation of SatM from their committed progenitor PMID: 28002407
31. The stimulation of CCAAT/enhancer binding protein (C/EBP) beta expression by interleukin-1beta following muscle injury and in cancer cachexia acts to promote muscle satellite cells survival. PMID: 26913600
32. Cebpb phosphorylation is inhibited by retinoic acid. PMID: 26271478
33. C/EBPbeta controls M2-macrophage gene expression in the heart. Thus, C/EBPbeta appears as a transcription factor required for cardiac hypertrophy response to gestation. PMID: 26476039
34. Suggest Hmgn1/Cebpb signaling may play an important role during mouse decidualization. PMID: 26566865
35. HMGA2 is required for C/EBPbeta-mediated expression of PPAR gamma, and thus promotes adipogenic differentiation. PMID: 26966068
36. This study showned that the transcription factor C/EBPbeta directly regulates the expression of the C3 gene, and that this control could be relevant for the pro-inflammatory effects of this transcription factor PMID: 25617152
37. Loss of C/EBPbeta expression in primary myoblasts rescues differentiation under cachectic conditions without restoring myotube size, indicating that C/EBPbeta is an important inhibitor of myogenesis in cancer cachexia. PMID: 26709824
38. PKR inhibition reduced the expression of eIF4B and C/EBPbeta in an eIF2alpha-independent manner PMID: 26646662
39. Pharmacologic stimulation of C/EBPbeta expression reprograms myoblasts to a more stem cell-like state, promotes expansion in culture, and improves engraftment such that better transplantation outcomes are achieved. PMID: 26941360
40. propose that the pathology of MCDS is underpinned by XBP1 independent UPR-induced dysregulation of C/EBP-beta-mediated chondrocyte differentiation PMID: 26372225
41. C/EBPbeta contributes to immunity to mucosal candidiasis during cortisone immunosuppression in a manner linked to beta-defensin 3 expression, but is apparently dispensable for the IL-17-dependent response. PMID: 26317211
42. Data suggested that translational adjustment of C/EBPbeta-isoform expression is one of the key processes that direct metabolic adaptation in response to changes in mTORC1 activity. PMID: 26113365
43. NF-IL6 plays a dual role for sickness response and immune-to-brain communication: acting pro-inflammatory at 8h but anti-inflammatory at 24 h after onset of the inflammatory response reflecting active natural programming of inflammation. PMID: 25813145
44. Overexpression of LIP significantly reduced the level of polyomavirus JC T-antigen. PMID: 26017382
45. Par4, CEBPB and FAK form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT and self-renewal PMID: 25472717
46. Simulated microgravity activates a p38 MAPK-C/EBPbeta pathway in macrophages to up-regulate arginase and IL-6 expression and down-regulate IL-12B expression PMID: 25804385
47. C/EBPbeta was the main regulator of P2X7 receptor expression in response to a glucose challenge. C/EBPalpha and the C/EBPbeta-LIP isoform blocked the C/EBPbeta-dependent regulation of P2X7 receptor transcription. PMID: 25403356
48. C/EBPbeta and RUNX2 cooperatively stimulate expression of Ihh through direct interactions with a C/EBPbeta binding element, which further promotes hypertrophic differentiation of chondrocytes during the chondrocyte differentiation process. PMID: 25105964
49. Adamts-1 upregulation by inducers of pathological vascular remodeling is mediated by specific signal transduction pathways involving NFAT or C/EBPbeta transcription factors. PMID: 26217013
50. C/EBPbeta controls lymphoma-associated dendritic cell cytokine expression. PMID: 25266931

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KEGG: mmu:12608

STRING: 10090.ENSMUSP00000069850

UniGene: Mm.439656