Recombinant Mouse CDK5 and ABL1 enzyme substrate 1 (Cables1)

Code CSB-YP884155MO
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP884155MO
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP884155MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP884155MO
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP884155MO
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
Cables1
Uniprot No.
Alternative Names
Cables1; CablesCDK5 and ABL1 enzyme substrate 1; Interactor with CDK3 1; Ik3-1
Species
Mus musculus (Mouse)
Expression Region
1-568
Target Protein Sequence
MAAATATAGT AACSSSSSSR GGSTDAAATS GVQPPPPPPA TAPPEPLRKP RMDPRRRQAA LSFLTNISLD GRPPLQDHEW GGGEEGGGTK PGARARLSLL AAGCNAFSAP GTAAAPWTAG SGSSPCPLPP SLVPRVLGEP SQPPRSAPAV TGAQLQLPDG PGGAGQEELE EDDAFTNVQV PSASFLGSGT PGSTSGSRGR LNSFTQGILP IAFSRQNSQN YCALEQSGQG GSTSALEQLQ RSRRRLISQR SSLETLEDIE ENAPLRRCRT LSGSPRPKNF KKIHFIKNMR QHDTKNGRDL KLDGGRQSAG AMSLKEIIGL EGVELGADGK TVSYTQFLLP TNAFGNRRNT IDSTASFSQF RSLSHRSLSM GRAGSTQGSL DAGSDLGDFM DYDPNLLDDP QWPCGKHKRV LTFPSYMTTV IDYVKPSDLK KDMNETFKEK FPHIKLTLSK IRSLKREMRK LAQEDCGFEE PTVAMAFVYF EKLALRGKLN KQNRKLCAGA CVLLAAKVGS DLRKHEVKHL IDKLEEKFRL NRRELIAFEF PVLVALEFAL HLPEHEVMPH YRRLIQSS
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death.
Gene References into Functions
  1. Loss of Cables1 enhances tumor progression in the Apc(Min/+) mouse model and activates the Wnt/beta-catenin signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model. PMID: 23792637
  2. Agenesis of the corpus callosum frequency in Cables1(+/TAS) mice was significantly lower than that in Cables1(-/TAS) mice, indicating that wild-type Cables1 interfered with the dominant negative effect of Cables1(TAS). PMID: 24336072
  3. Cables may be involved in the pathogenesis of ovarian carcinomas PMID: 13679449
  4. Loss or suppression of Cables may be an early step in the development of endometrial cancer. PMID: 14729625
  5. Cables is a relevant target of the chromosome 18q deletions frequently seen in human colorectal cancer. PMID: 16210915
  6. Cables1 null mice exhibit a significant expansion of oocyte numbers at the expense of oocyte quality throughout adulthood. PMID: 17912041

Show More

Hide All

Subcellular Location
Nucleus. Cytoplasm. Cell projection, growth cone. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.
Protein Families
Cyclin family
Tissue Specificity
Ubiquitous. Expressed in postnatal day 1 (P1), in postmitotic neurons of the subplate, cortex (V/VI) and marginal zone; in postnatal day 7 (P7), in all layers of the cerebral cortex and in the CA1 and CA2 regions of the hippocampus (at protein level). Hig
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1