Recombinant Mouse CREB-regulated transcription coactivator 1 (Crtc1)

1. Collectively, these findings highlight the male-specific involvement of CRTC1 in the central control of energy balance and circadian locomotor activity. PMID: 29217834
2. CRTC1 selectively plays protective role against nonalcoholic fatty liver disease development.CRTC1 also mediates anti-lipogenic effects of bile acid signaling, whereas it is negatively regulated by miR-34a. PMID: 27869139
3. the HDAC3-N-CoR corepressor complex leaves the Fgf1b promoter and a complex involving the translocated CRTC1, phosphorylated CREB, and histone acetyltransferase CBP induces transient transcription. PMID: 28076781
4. this study shows that mTORC1 activation is required for fueling B cells prior to dark zone proliferation rather than for allowing cell-cycle progression itself and must be regulated dynamically during cyclic re-entry to ensure efficient affinity-based selection PMID: 28636954
5. The NR2B-CREB-miR212/132-CRTC1-CREB signal network plays an important role in the regulation of pain. PMID: 28244951
6. Findings reveal a critical role of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus during associative memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegeneration. PMID: 27587263
7. Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response PMID: 28069808
8. Study suggests that CRTC1 is a key regulator of behavioral and molecular response to antidepressant: CRTC1 is required for complete behavioral antidepressant response and for desipramine-induced expression of Bdnf and Nr4a1-2. By acting downstream of CRTC1, the HDAC inhibitor SAHA improves the depressive-like behavior of Crtc1-/- mice. PMID: 26970016
9. Upregulation of CRTC1 enhancing CREB-dependent gene transcription in spinal cord may play an important role in bone cancer pain. PMID: 27060162
10. This study demonstrates that TSC1- mechanistic target of rapamycin complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1] PMID: 25213336
11. These data identify Notch as a therapeutically actionable branch point of metabolic signaling at which Akt activation in the liver can be uncoupled from hepatosteatosis.[mTORC1] PMID: 23832089
12. aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 [mTORC1] PMID: 23109424
13. CRTC1 has a wide impact on CREB-dpendent memory processes and fine-tunes CREB output in a region-specific manner. PMID: 25277455
14. PDK4 promotes tumorigenesis through activation of the CREB-RHEB-mTORC1 signaling cascade. PMID: 25164809
15. mTORC1 activity is necessary and sufficient for the transition of satellite cells from G0 into G(Alert) and that signalling through the HGF receptor cMet is also necessary PMID: 24870234
16. Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer Disease. PMID: 24760838
17. Fisetin inhibits Akt-mTORC1 signaling in 3T3-L1 preadipocytes and white adipose tissue in HFD-fed mice. PMID: 23517912
18. Report dose-dependent suppression of mTOR activity by IL-6 and suppressed mTOR responsiveness to glucose administration in Apc(Min/+) mice. IL-6 suppression of mTOR activity was dependent on AMPK activation and independent of STAT signaling in myotubes. PMID: 23531613
19. impaired expression and function of TORC1, which results in a reduction in PGC-1alpha, plays an important role in mitochondrial dysfunction in HD PMID: 22589249
20. mTORC1 and Akt have different yet synergistic effects during the development of liver tumors in mice. PMID: 23376645
21. CaMKIalpha regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation. PMID: 23447692
22. increasing CRTC1 function is sufficient to enhance the strength of new, as well as established reactivated, memories without compromising memory quality. PMID: 23223304
23. results suggest that denervation induces not only muscle degradation but also adaptive muscle response in a proteasome- and mTORC1-dependent manner PMID: 23209294
24. The data of this study supported that a role for the CRTC1-CREB pathway in mood disorders etiology and behavioral response to antidepressants and identify CRTC1 as an essential coactivator of genes involved in mood regulation. PMID: 22592058
25. Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity. PMID: 22770221
26. Data suggest that increased activation of mTORC1 can promote carcinogenesis. PMID: 22457330
27. The neuroprotective effect of Sirt1 requires the presence of CREB-regulated transcription coactivator 1 (TORC1), a brain-specific modulator of CREB activity. PMID: 22179316
28. TORC1 increases the Gonadotropin-releasing hormone activation of the Follicle Stimulating Hormone promoter and works synergistically with Nur77 and/or CREB. PMID: 21986493
29. Results indicate that CRTC1 protein is expressed in submandibular salivary gland epithelia during early stages of morphogenesis, disappears with differentiation, and reappears in initial tumor-like pathology. PMID: 20837164
30. Data find that TORC1 activity is transiently upregulated during the endoderm-intestine transition in mouse. PMID: 20925120
31. These findings suggest that CRTC1 plays a key role in coupling synaptic activity to gene transcription required for hippocampal-dependent memory, and that beta-amyloid could disrupt cognition by affecting CRTC1 function. PMID: 20631169
32. mTORC1 signaling plays a major role in the integration of the mitogenic signal in follicular thyroid cancer. PMID: 20299527
33. Effect of activation and inhibition of the mammalian TORC1 signaling pathway on the expression of adipose triglyceride lipase. PMID: 20068142
34. Tsc1/mTORC1 signaling and PTEN/PI3K signaling synergistically regulate the dormancy and activation of primordial follicles. PMID: 19843540
35. TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus PMID: 17360587
36. These studies uncover a critical role for the Tsc2/mTOR pathway in regulation of beta cell mass and carbohydrate metabolism in vivo. PMID: 18587048
37. Data suggest that mTORC1 controls translation of leptin mRNA via a novel mechanism that does not require the presence of either the 5'-terminal oligopyrimidine tract or the 5'-UTR. PMID: 18653778
38. mTORC1 promotes survival through translational control of Mcl-1. PMID: 18664580
39. the Creb1-Crtc1 pathway mediates the central effects of hormones and nutrients on energy balance and fertility. PMID: 18758446
40. TSC1 is a critical regulator of hematopoietic stem cell self-renewal, mobilization, and multilineage development and executes these actions via both mTORC1-dependent and -independent pathways PMID: 19052232
41. findings suggest that mTORC1 mediates glucose amplification of lipotoxicity, acting through activation of endoplasmic reticulum (ER) stress and JNK; mTORC1 is an important transducer of ER stress in beta-cell glucolipotoxicity PMID: 19305497
42. Crtc1 may be required for the hypothalamic expression of genes that mediate the effects of leptin on energy balance but not on fertility. PMID: 19734865

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KEGG: mmu:382056

STRING: 10090.ENSMUSP00000075916

UniGene: Mm.227767