Recombinant Mouse Calpain-2 catalytic subunit (Capn2)

1. these findings identify ASAP2 as a new target of Selk-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis. PMID: 27601625
2. ENaC activity is regulated by calpain-2 proteolysis of MARCKS. PMID: 28468944
3. These results suggest that TRPV1/Ca(2+)/calpain 2-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors. PMID: 28360106
4. Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension. PMID: 26248159
5. Dicer is predominantly a Capn2 substrate. Dicer levels were altered in platelets from diabetic mice due to the cleavage of the enzyme by calpain, resulting in loss of function. PMID: 25944670
6. Data suggest that vitamin D3 up-regulates skeletal muscle fat deposition, up-regulates muscle m-calpain/Capn2 and u-calpain/Capn1 expression, and down-regulates muscle calpastatin expression. PMID: 25520983
7. Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 and TMOD4 leads to thin filament elongation in dystrophic skeletal muscle. PMID: 24430868
8. extrasynaptic NMDAR-coupled m-calpain activation is neurodegenerative PMID: 24285894
9. Down-regulated expression of calpain-2 or talin-1, or pharmacological interference with calpain action, did not affect toxin binding but reduced endocytosis and increased the survival of cells exposed to anthrax lethal toxin. PMID: 24085852
10. The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading. PMID: 23466492
11. Calpain-2 was required for FFA-induced expression of CHOP and activation of caspase-12 and caspase-3, thus promoting cell apoptosis in beta-TC3 cells. PMID: 23527285
12. Calpain2 gene silencing eliminated long-term potentiation and impaired learning and memory. The calpain2 isoform is a critical mediator in learning and memory. PMID: 22903378
13. Our results indicate that prolonged calpain expression in resident brain cells (neurons, glial and endothelial cells) plays an important role in neuronal degeneration following traumatic brain injury. PMID: 23390828
14. cleavage of CPEB3 by NMDA-activated calpain 2 accounts for the activity-related translation of CPEB3-targeted RNAs PMID: 22711986
15. Activation of calpain-1/2 are associated with increased lipid peroxidation and low-density lipoprotein oxidation in the brain of hyperlipidemic mice. PMID: 21836084
16. Data suggest that that calpain 2 promotes tumor cell growth both in vitro and in vivo through the PI3K-Akt-FoxO-p27(Kip1) signaling cascade. PMID: 22427650
17. The ability of mouse lens epithelium to maintain lens transparency would be compromised by activation of calpain 2 and associated necrotic cell death. PMID: 21950698
18. Subtype-selective induction of m-calpain in aorta during atherosclerotic progression is associated with proteolytic disorganization of VE-cadherin and proatherogenic hyperpermeability in cells. PMID: 22064597
19. Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor 2,3,4 and 9-induced calpastatin in macrophages PMID: 21849499
20. m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate. PMID: 20729206
21. determined that semaphorin 3A-mediated calpain activation and growth cone collapse were associated with m-calpain phosphorylation PMID: 20643936
22. Capn2 plays a role in fundamental mitotic functions, such as the maintenance of sister chromatid cohesion. PMID: 20094891
23. analysis of a novel role for calpain proteolysis of FAK in regulating adhesion dynamics in motile cells PMID: 20150423
24. m- or mu-calpain can facilitate repair of damaged plasma membrane. PMID: 19781581
25. Our findings support a novel role for calpain 2 in limiting membrane protrusions and in regulating lamellipodial dynamics at the leading edge of migrating cells. PMID: 15302585
26. Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin PMID: 15817486
27. calpain-dependent cleavage of amphiphysin I inhibits synaptic vesicle endocytosis during neural hyperexcitation and demonstrate a novel post-translational regulation of endocytosis PMID: 17541403
28. These results indicate that m-calpain requiring millimolar Ca(2+) level for the full activation plays specific roles in myogenesis. PMID: 18216163
29. From 8-cell stage to late neurulation stages, CAPN2 is expressed in the cytoplasm and nuclear compartments. In situ hybridization analysis from E8.5 to 14.5 stages indicates high levels of capn2 expression in nervous system, heart and mesodermal tissues PMID: 18415939

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KEGG: mmu:12334

STRING: 10090.ENSMUSP00000068895

UniGene: Mm.19306