Recombinant Mouse Caspase-1 (Casp1), partial

1. ABT-737 elicited an anti-atopic dermatitis (AD) activity via suppression of caspase-1 activation in AD in vitro and in vivo models. Therefore, this study provides important information regarding the use of anticancer drugs for controlling allergic inflammatory diseases. PMID: 29957081
2. Casp1Null mice expressed caspase-11 proteins and did not secrete IL-1beta and IL-18 or undergo pyroptosis in response to canonical NLRP3, NLRC4 or AIM2 inflammasome activators. PMID: 28345580
3. The enzymatic activities of caspase-1 and caspase-11 are required for growth inhibition in different cell types.These results reveal that these proteases have important functions beyond the direct induction of pyroptosis and proinflammatory cytokine secretion in the control of growth and elimination of cytosolic bacteria. PMID: 27808091
4. Collectively, these results are consistent with a model whereby the type III secretion system apparatus of Pseudomonas aeruginosa activates the caspase-1-dependent inflammasome and caspase-3/7 through an ASC-dependent mechanism. PMID: 29957172
5. The results of this study indicated that beta-Amyloid peptide-induced caspase-1 activation, disrupts autophagy in the cortex and in the hippocampus resulting in neurodegeneration and memory loss. PMID: 28801921
6. caspase-1 regulates dopaminergic neuronal death in the pathogenesis of Parkinson's disease in mice via caspase-7/PARP1/AIF pathway. PMID: 27339879
7. RIP3-mediated activation of caspase-1 rather than necroptosis-dependent inflammation was responsible for aggressive inflammation in influenza A (H7N9) virus-infected mice. PMID: 28423682
8. we assessed the role of RIP3 in synergy with Caspase-1 in the induction of IL-1beta production in BMDM after either LPS/ATP or Chlamydia muridarum stimulation. The possibility of pyroptosis and necroptosis interplays and the role of RIP3 in IL-1beta production during Chlamydia muridarum infection in BMDM was investigated as well. PMID: 28660207
9. Studied the role of transient receptor potential melastatin 2 (TRPM2) in activating caspase-1 and caspase-1-dependent pyroptosis in mouse BMDMs. Found TRPM2 knockout caused higher caspase-1 activation and pyrotopsis. PMID: 29250536
10. The results demonstrate the activation of the caspase 1 precursor by caspase 11 and suggest a new mechanism of protection of Theiler murine encephalomyelitis virus-infected astrocytes from apoptosis. PMID: 26567013
11. Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines and caspase-1 activation PMID: 28407357
12. Adult neural stem cells (ANSCs) expressed NLRP3-containing inflammasome and alpha-syn activated both TLR4/NF-kappaB and NLRP3/caspase-1 signals in ANSCs. PMID: 26676570
13. dimerized or endogenous caspase-8 can also directly cleave IL-1beta into its biologically active form, in the absence of canonical inflammasome components. PMID: 27419363
14. Report direct role of pleural cells in the pathogenesis of bleomycin-induced pulmonary fibrosis via caspase-1/IL-1beta pathway. PMID: 27894300
15. caspase-1-/- mice exhibited resistance to indomethacin-induced small intestinal damage PMID: 26349656
16. data provide evidence that the NLRC4 inflammasome contributes to resistance through regulation of caspase-1, IL-1beta and IL-18 in a CD11blowLy6Glow population of cells PMID: 28961278
17. Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis following lipopolysaccharide exposure through TLR4, which activates Nlrp3, and subsequently induces caspase-1 activation. PMID: 27607578
18. The most well-known function of active caspase-1 is to cleave the proforms of inflammatory cytokines IL-1beta and -18 into their active forms in response to inflammatory stimuli in immune cells. Caspase-1 has multiple functions in addition to this cytokine maturation role. It is at the center of many cell responses to stress and inflammation not just in immune cells but in other cell types, such as epithelia. Review. PMID: 27450556
19. Findings demonstrate a critical role of caspase-1 in macrophage-driven inflammation in the adipose tissue and the development of obesity. PMID: 27702746
20. Inflammasome NLRP3-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development. PMID: 28153878
21. Data indicate that NLRC4 activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 release, and implicate Caspase-8 in NLRC4 inflammasome responses in vivo by generation of doubly deficient in Caspase-1 and Caspase-8. PMID: 28410991
22. our studies have uncovered a specific role for caspase-1-mediated IL-1beta release in the manifestation of Familial Mediterranean Fever PMID: 27998728
23. variant p.C284A caspase-1 stabilizes pyroptosome formation, potentially enhancing inflammation by two IL-1beta-independent mechanisms: pyroptosomes convey an enhanced inflammatory stimulus through the recruitment of additional proteins (such as RIP2, receptor interacting protein kinase 2), which is further amplified through pyroptosome and cell division. PMID: 27402835
24. TNF-alpha induces caspase-1 activation in an inflammasome-independent manner in 3T3-L1 cells and that the ERK-dependent expression of NLRP3 may play a role independently of its canonical role as a component of inflammasomes. PMID: 26989816
25. caspase-1 activation is an upstream event of apoptotic caspase-7 induction in renal tubulointerstitial fibrosis PMID: 27643624
26. it was found that GSK2656157 specifically inhibited ER stress induced by large amount of LPS and reduced LPS-induced IL-1beta production through inhibition of Caspase 1 activation. PMID: 27251848
27. Study suggests that Casp1 has a limited role in the development of burn-induced pain. PMID: 28040362
28. Data show that inhibiting caspase-1 activity in the NLR family, pyrin domain-containing 3 protein (NLRP3) inflammasome decreased gastric cell apoptosis. PMID: 27053298
29. Chronic kidney disease-mediated increase of contractile markers in vascular smooth muscle cells and increased expression of VSMC migration molecule alphavbeta3 integrin in NH formation were caspase-1 dependent. PMID: 26928596
30. Demonstrate the utility of intracellular caspase 1 and extracellular CTSS proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation. PMID: 27108091
31. Caspase-1-/- mice have intact immune responses but do not develop an expanded marginal zone B cell population in response to pristane-induced lupus. This may be one explanation for reduced IgG autoantibody production in these mice. PMID: 26405027
32. study uncovered an important role for YopJ in inhibiting caspase-1 in activated macrophages and in promoting Yersinia virulence PMID: 26810037
33. Caspase-1-activated IL-18 induces IFN-gamma to prime caspase-11 and rapidly clear Burkholderia thailandensis infection. PMID: 26320999
34. These results argue that caspase-1, -4 or -5 can be recruited to inflammasomes under specific circumstances, often leading to distinctly organized and localized complexes that may impact the functions of these proteases PMID: 26158519
35. Prophylactic treatment with capsase-1 inhibitor VX756 ameliorated the severity and progression of collagen-induced arthritis. PMID: 26742834
36. The resilience of casp1(-/-) mice to SIRS lethality is associated with a lower inflammatory response, loss of hippocampal gene coexpression patterns, and increased hippocampal Adamts1 gene expression. PMID: 25633245
37. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes. PMID: 26466953
38. This study highlights a critical role of caspase-1 activation and NLPR3/ASC inflammasome complex in the down-modulation of IL-33 in vivo and in vitro. PMID: 25714839
39. Data show that caspase-1 but not caspase-11 was essential for the functional activities of the NLRC4 inflammasome. PMID: 26232428
40. Data indicate that genetic ablation of caspase-1 and -11 from cpdm mice significantly reduced skin inflammation in sharpin-deficient mice. PMID: 26216893
41. In an inflammatory microenvironment, caspase-1 is regulated by NF-kappaB. PMID: 25815426
42. ASC-driven caspase-1 autoprocessing and speck formation are dispensable for the activation of caspase-1 and the NLRP1b inflammasome. PMID: 24492532
43. The signalling pathway governing the inflammasome formation in the heart requires a priming signal in order for an active NLRP3 to induce caspase-1 activation PMID: 25524927
44. GATA4, a key regulator of cardiomyocyte survival, is a substrate for caspase-1. PMID: 25501827
45. Data (including data from studies in knockout mice) suggest that caspase-1/11 are involved in development of atherosclerosis; hematopoietic deletion of caspase-1/11 results in strong reduction in atherosclerotic plaque size. PMID: 25817537
46. There may be a protective role of caspase-1 in keratinocytes during UVB-induced skin cancer development through the induction of apoptosis. PMID: 25562666
47. These findings suggest that endogenous caspase-1/11 activity, independent of the NLRP3 inflammasome, not only promotes the magnitude of the inflammatory response, but also suppresses protective immunity in the neonate PMID: 25684123
48. Data suggest that Casp1 is activated and expression/nucleocytoplasmic translocation of Hmgb1 (high mobility group box 1) is up-regulated in pulmonary mucosa in asthma; these changes involve PI3K (phosphatidylinositol 3-kinase) signal pathway. PMID: 25929181
49. Inflammasome-induced activation of an intracellular caspase-1/calpain cysteine protease cascade degraded filamin. Caspase-1 specifically facilitated actin exposure, which released of highly procoagulant MPs from filopodia. PMID: 25705884
50. caspase-1/ASC inflammasomes play a significant role in the activation of IL-1beta/ROS and NF-kappaB signaling of cytokine gene expression for T. cruzi control in human and mouse macrophages. PMID: 25372293

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KEGG: mmu:12362

STRING: 10090.ENSMUSP00000027015

UniGene: Mm.1051