Recombinant Mouse Caspase-4(Casp4)

Code CSB-YP004549MO
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Source Yeast
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Code CSB-EP004549MO
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Source E.coli
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Code CSB-EP004549MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004549MO
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Source Baculovirus
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Code CSB-MP004549MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Casp4
Uniprot No. P70343
Alternative Names CASP-11; CASP-4; CASP11; CASP4; CASP4_MOUSE; Caspase 11; Caspase 11 apoptosis related cysteine peptidase; Caspase 11 apoptosis related cysteine protease; Caspase 4; Caspase 4 apoptosis related cysteine peptidase; Caspase-11; Caspase-4 subunit p20; CASPL; Ich 3; Ich3; ICH3 protease; Protease ICH-3
Species Mus musculus (Mouse)
Expression Region 81-266
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Proinflammatory caspase
Gene References into Functions
  1. Together, these data suggest that caspase-11/IL-1alpha pathway plays an important role in defending against Klebsiella pneumoniae by recruiting neutrophils in the early stage of infection. PMID: 28939441
  2. Results indicate functional differences between human caspase-4 and murine caspase-11 (caspase 4). PMID: 29339744
  3. Data suggest that Brucella melitensis effector protein TcpB suppresses caspase-4/11--mediated inflammation, subverting inflammasome activation in mouse macrophages; TcpB induces ubiquitination/degradation of caspase-4/11; TcpB suppresses caspase-4/11--mediated pyroptosis and proinflammatory responses induced by lipopolysaccharide. PMID: 29061850
  4. systemic exposure to the bacterial endotoxin lipopolysaccharide (LPS) causes severe endothelial pyroptosis that is mediated by the inflammatory caspases, human caspases 4/5 in human ECs, or the murine homolog caspase-11 in mice in vivo. PMID: 28990935
  5. Caspase-l, Caspase-11 and Dectin-1/syk pathway are involved in the IL-1beta generation in fungal keratosis. PMID: 28167474
  6. These data indicate that the caspase-11-mediated innate immune response plays a crucial role in defending against Acinetobacter baumannii. PMID: 28760936
  7. Hyperactive dendritic cells induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxidized phospholipids and bacterial lipopolysaccharide. PMID: 27103670
  8. gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation PMID: 26375259
  9. But not in Casp11(-/-), Panx1(-/-), or P2x7(-/-) mice. PMID: 26572062
  10. active caspase-11 leads to a drop of intracellular potassium levels, which is necessary to activate NLRP3. PMID: 26173909
  11. These results suggest a role for other caspase-11 effector mechanisms such as pyroptosis in protection against intestinal inflammation. PMID: 24850431
  12. Caspase-11 limits the response of CD8+ T-cells to low-abundance and low-affinity antigens. PMID: 25980012
  13. These data show that both Candida albicans Sap2 and Sap6 can activate caspase-11 through type I interferon (IFN) production. PMID: 25712931
  14. these data suggest that IFN-gamma-mediated caspase-11 expression has a key role maintaining intestinal epithelial barrier integrity in vivo during experimentally induced acute colitis. PMID: 25548224
  15. The caspase-4/11 inflammasome also governs activation of the proinflammatory cytokine, interleukin (IL)-18, in response to intracellular and extracellular enteric pathogens. PMID: 25121752
  16. Lipopolysaccharides may be sensed in the cytosol of cells by a noncanonical inflammasome pathway, resulting in the activation of the cysteine protease caspase-11. [Review] PMID: 25347553
  17. identify caspase-11 as a critical factor protecting the host during acute dextran sulfate sodium-induced colonic injury and inflammation but not during chronic inflammation and tumorigenesis PMID: 25414099
  18. function of caspase-4/5/11 represents a new mode of pattern recognition in immunity and also an unprecedented means of caspase activation PMID: 25119034
  19. caspase-4 can support activation of caspase-1 and secretion of IL-1beta and IL-18 in response to priming signals (LPS or Pam3CSK4) alon PMID: 24879791
  20. a cluster of small interferon-inducible GTPases, the so-called guanylate-binding proteins, is required for the full activity of the non-canonical caspase-11 inflammasome during infections with vacuolar Gram-negative bacteria PMID: 24739961
  21. IFN-inducible guanylate binding protein (Gbp) proteins stimulate caspase-11-dependent, cell-autonomous immunity in response to cytoplasmic lipopolysaccharides. PMID: 24715728
  22. Emerging data point to a cascade of events during which caspase-11 promotes and corroborates caspase-1 activity through NLRP3 inflammasomes. Caspase-11 is also capable of independently inducing pyroptotic cell death.[Review] PMID: 23870309
  23. virulent, but not avirulent, bacteria trigger a rapid caspase-11-dependent innate immune response important for host defense. PMID: 23762026
  24. review gathers together studies on both the mechanisms and implications of caspase-11-mediated noncanonical inflammasome activation, and discuss the emerging importance of this pathway in regulating host defense against intracellular bacterial pathogens PMID: 24037676
  25. study reports that caspase-11 is required for innate immunity to cytosolic, but not vacuolar, bacteria PMID: 23348507
  26. TLR4- and TRIF-induced caspase-11 synthesis is critical for noncanonical Nlrp3 inflammasome activation in macrophages infected with enteric pathogens. PMID: 22898816
  27. non-canonical caspase-11 activation contributes to macrophage death during S. typhimurium infection PMID: 22895188
  28. Caspase-11 activation via the TLR4-TRIF-IFNbeta pathway synergizes with the NLRP3 pathway to coordinate caspase-1-dependent IL-1beta and IL-18 secretion and also leads to caspase-1-independent cell death. PMID: 22819539
  29. found that, despite extensive backcrossing into a C57BL/6 background, c-IAP1(-/-) animals are also deficient in caspase 11 PMID: 22332634
  30. data highlight a unique pro-inflammatory role for caspase-11 in the innate immune response to clinically significant bacterial infections PMID: 22002608
  31. PARP-1, as a transcriptional cofactor for NF-kappaB, regulates the induction of caspase-11 at a transcriptional level. PMID: 21530491
  32. TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. PMID: 21269505
  33. 11 is an essential molecule in NO-independent apoptotic pathway of activated astrocytes. PMID: 11902113
  34. gene expression in response to LPS and interferon-gamma requires NF-kappaB and Stat1 binding PMID: 12198138
  35. In a mouse model of ALS neurodegeneration, inflammatory responses, and disease onset and progression in SOD1 G93A transgenic mice were not altered by the ablation of caspase-11 gene PMID: 12843244
  36. the neurotoxic effects of LPS on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and caspase-11 expression in mice PMID: 15383538
  37. Caspase-11 regulates cell migration during inflammation. PMID: 17293856
  38. Our results suggest that neuroinflammation related to the caspase-11 cascade in the striatum regulates differentiation of neural stem cells in the SVZ of our mouse model of PD. PMID: 17963913
  39. Caspase-11 plays a critical role in TPEN-induced apoptosis. PMID: 18474237
  40. Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation. PMID: 19531658
  41. Ask1 regulates the expression of caspase-11 following LPS stimulation PMID: 19695249

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Subcellular Location Cytoplasm, cytosol, Cytoplasm, Endoplasmic reticulum membrane, Peripheral membrane protein, Cytoplasmic side, Mitochondrion, Inflammasome, Secreted
Protein Families Peptidase C14A family
Tissue Specificity Widely expressed, including in thymus, lung and spleen (at protein level). Very low levels, if any, in the brain.
Database Links

KEGG: mmu:12363

STRING: 10090.ENSMUSP00000027012

UniGene: Mm.1569

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