Recombinant Mouse Catenin delta-1 (Ctnnd1), partial

1. over-expression of P120-catenin suppressed NF-kappaB signaling and reversed the inflammatory effects. P120-catenin prevents endplate chondrocytes from undergoing ICMT-mediated inflammation by suppressing the expression of NF-kappaB. PMID: 28464387
2. p120 Catenin underexpression is associated with Invasive Pancreatic Neoplasia. PMID: 27032419
3. We conclude that p120ctn is not only an adaptor and regulator of E-cadherin, but is also indispensable for proper lineage commitment PMID: 27556156
4. p120 is required for dietary calcium suppression of oral carcinogenesis. PMID: 27682597
5. p120ctn has a critical role in biliary differentiation and is a potent suppressor of liver tumor growth. PMID: 27769530
6. a mechanistic link between E-cadherin loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso-dependent expression of Wnt11, is reported. PMID: 25713299
7. Delta-catenin activates Rac1 and Cdc42 but inhibits RhoA in lymphatic endothelial cells. PMID: 25635825
8. p120-catenin regulates REST and CoREST and modulates mouse embryonic stem cell differentiation. PMID: 25074806
9. Data indicate that p120 catenin is required for proper pancreatic tubulogenesis and branching morphogenesis. PMID: 25523391
10. p120 functions as a differential regulator of TLR4 signaling pathways by facilitating TLR4 endocytic trafficking in macrophages, and support a novel role for p120 in influencing the macrophages in the lung inflammatory response to endotoxin. PMID: 25015829
11. Shroom3 has a role in apical constriction during lens pit morphogenesis and is recruited in a pathway involving p120-catenin PMID: 25038041
12. The recruitment of M-cadherin to lipid rafts during pre-fusion myogenesis events depended on interaction with p120 catenin, whereas the organization of microrafts was controlled by a small G protein, Rac1. PMID: 23978243
13. ZBTB33 expression may elicit intestinal inflammation by antagonizing p120ctn function. PMID: 24040197
14. delta-catenin plays a key role in molecular processes underlying learning and memory: dynamic palmitoylation of delta-catenin can coordinate activity-dependent changes in synapse adhesion and structure and the efficacy of synaptic transmission. PMID: 24562000
15. Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha and downstream disruption of the p120-VE cadherin interaction in vascular endothelium. PMID: 23887639
16. we show that somatic loss of p120-catenin (p120) in a conditional mouse model of noninvasive mammary carcinoma results in formation of stromal-dense tumors that resemble human metaplastic breast cancer and metastasize to lungs and lymph nodes PMID: 23733751
17. mXinalpha directly interacts with p120-catenin and suppresses the p120-catenin-induced branching phenotype. PMID: 23296090
18. Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex. PMID: 23481397
19. Data indicate that PKCalpha phosphorylation of p120-catenin at S879 is a critical phospho-switch mediating disassociation of p120 from VE-cadherin that results in adherens junctions (AJ) disassembly. PMID: 22798526
20. Activation of E-cadherin induces p120-catenin dephosphorylation, as well as changes in the cadherin cytoplasmic domain. PMID: 22513089
21. RPTPmu tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation. PMID: 21998202
22. Findings reveal an essential role for p120 in mammary morphogenesis. PMID: 22461563
23. Results indicate that the vertebrate planar cell polarity pathway regulates cochlear convergent extension (CE) and hair cell polarity independently and that a p120-catenin-dependent mechanism regulates CE of the cochlea. PMID: 22318628
24. p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance PMID: 21747168
25. p120-catenin plays critical protective role in cyclic stretch-induced alveolar barrier dysfunction. Maintenance of p120-catenin expression may be novel therapeutic strategy for prevention and treatment of ventilator-induced lung injury. PMID: 21571907
26. Limited p120 ablation can promote tumorigenesis by an indirect non-cell autonomous mechanism. PMID: 21611205
27. p120ctn is required for early tubule and glomerular morphogenesis, as well as control of luminal diameter, probably through regulation of cadherins. PMID: 21521738
28. report herein that p120ctn loss leads to tumor development in mice PMID: 21481789
29. p120-mediated inhibition of Toll-like receptor (TLR)4 signaling represents an important innate immune mechanism capable of regulating the lung host defense function. PMID: 21278343
30. p120 stabilized ameloblast intercellular interactions during the secretory stage of dental enamel development. PMID: 20862276
31. Results suggest that p120 acts as an obligate intermediate between ErbB2 and Rac1/Cdc42 to modulate the metastatic potential of breast cancer cells. PMID: 20595387
32. The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin PMID: 20395297
33. Reveal a fundamental role for p120 in regulating endothelial cadherin levels during vascular development. Loss of endothelial p120 results in lethality attributable to decreased microvascular density and hemorrhages. PMID: 20110533
34. binding of p120ctn to microtubules is inversely related to its ability to regulate Rho GTPases PMID: 14660598
35. cytoplasmic p120 can associate both directly and indirectly with the microtubule network, and p120 traffics along microtubules toward their plus ends PMID: 14676216
36. epigenetic choice of active allele is clonally stable and that biallelic clones express p120 at twice the level of monoallelic clones PMID: 15522875
37. p120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis. PMID: 15543138
38. development and show that p120 ablation by itself induces effects consistent with a role in tumor progression. PMID: 16399075
39. p120 null epidermal cells activate nuclear NFkB, triggering a cascade of proinflammatory NFkB targets. PMID: 16469707
40. p120 catenin plays an important role in maintaining the basal tone of membrane protein trafficking in adipocytes through the dual regulation of Rho and Rac function. PMID: 16754687
41. Thus, p120ctn acts as a signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during spine and synapse development. PMID: 16815331
42. Rac activation links diverse signaling systems to adherens junction assembly by controlling transient p190RhoGAP interactions with p120 and localized inhibition of Rho. PMID: 17129786
43. p120ctn is necessary in the myelinating Schwann cell for the formation of mature adherens junctions and a normal myelin sheath PMID: 17382558
44. P120 has the ability to regulate microtubule dynamics and affects cell motility independently of the cadherin adhesion system. PMID: 17584295
45. Transfected delta-catenin T454A reduced the length and number of mature mushroom shaped spines in rat primary hippocampal neurons. PMID: 17993462
46. the novel function of the p120 C-terminal region in regulating the trafficking of cytoplasmic E-cadherin PMID: 18159125
47. both E-cadherin and p120 are important regulators of tumor cell growth and imply roles for both proteins in chemoresistance and targeted therapeutics. PMID: 19015320
48. In Drosophila, The Neurons expressing H134R-ChR2 show enhanced responses to blue light pulses and less spike frequency adaptation than neurons expressing ChR2. PMID: 19339465
49. GSK-3 interacts with and phosphorylates delta-catenin and thereby negatively affects its stability by enabling its ubiquitination/proteosome-mediated proteolysis PMID: 19706605

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KEGG: mmu:12388

STRING: 10090.ENSMUSP00000064518

UniGene: Mm.35738