Recombinant Mouse Cell surface glycoprotein MUC18 (Mcam), partial

1. findings suggest that MCAM is a gene upregulated and involved in maintaining PPARgamma induction in the late but not in the early stages of 3T3-L1 fibroblasts adipogenesis. PMID: 29468504
2. The dynamic expression of CD146 controls the behavior of ECs and pericyte. PMID: 28827364
3. In summary, we have shown that MUC18/Muc18 may serve as a regulator of airway inflammation and mucus overproduction, two important features of type 2-high asthma. Our data suggest that MUC18/Muc18 or its downstream signaling mediators may be targets for potential therapeutic agents. PMID: 28451734
4. These findings identify CD146 as a novel retention signal that traps macrophages within the artery wall, and a promising therapeutic target in atherosclerosis treatment. PMID: 28084332
5. Activation of the proteolytic processing of short isoform CD146, in particular by soluble CD146, constitutes a promising pathway to improve endothelial progenitors' regenerative properties for the treatment of cardiovascular diseases. PMID: 27170199
6. Study shows that Mcam is upregulated in cells that have a migratory phenotype upon MEIS1 overexpression and identi fi ed a MEIS1 consensus site 113 kb upstream of the Mcam tran- scriptional start site. PMID: 27583552
7. Different intrinsic co-factors in different K1735 sublines, which modulate the functions of MCAM/MUC18 in the cells that interact differently to the tumor microenvironment, may render sublines manifest differently in tumorigenicity and metastasis in vivo. PMID: 27510563
8. Results provide evidence that MUC18 promotes viral infections both in vivo and in vitro. PMID: 27701461
9. Microphthalmia-associated transcription factor regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule PMID: 26284703
10. Data show that CD146 was significantly higher expressed on tumor endothelium than on the liver. PMID: 26503468
11. Conditional knockout of the cd146 gene in the murine endothelium or disruption of netrin-CD146 interaction by a specific anti-CD146 antibody blocks or reduces netrin-1-induced angiogenesis. PMID: 25656845
12. MCAM is expressed by encephalitogenic CD8+ T lymphocytes in experimental autoimmune encephalomyelitis. Blocking or depleting MCAM in vivo reduces chronic neurological deficits in active, transfer, and spontaneous progressive EAE models. PMID: 25869475
13. Study demonstrate for the fi rst time that host CD146 contributes to hematogenous melanoma cell metastasis through a novel mechanism involving the VEGF/FAK/Ve-cadherin network. PMID: 25449773
14. Suggest endothelial CD146 as a target for specific drug delivery in hepatocellular carcinoma. PMID: 25238265
15. CD146 plays a dual role on endothelium, facilitating leukocyte extravasations and angiogenesis, thus promoting inflammation. PMID: 24767106
16. CD146 deletion in the nervous system impairs appetite, locomotor activity and spatial learning in mice. PMID: 24040184
17. Identified a novel negative regulator of angiogenesis, microRNA 329 (miR-329), that directly targeted CD146 and inhibited CD146-mediated angiogenesis in vitro and in vivo. PMID: 23878390
18. In addition, our data suggest that the AA98 is a promising candidate for treating MS and other CNS autoimmune diseases. PMID: 23595028
19. Alterations in CD146 are involved in the basic etiology of COPD/pulmonary emphysema. PMID: 23649916
20. MUC18 exerts a proinflammatory function during lung bacterial infection. PMID: 23256918
21. Data suggest that Mcam plays role in sustaining spermatogenesis and clonogenic activity of spermatogonial stem cells (SSC); Mcam appears to be involved in homing of transplanted SSC to testicular niche (but not in apoptosis or cell proliferation). PMID: 23053437
22. CD146 expression was significantly associated with high tumor stage, poor prognosis, and triple-negative breast cancer. PMID: 22210108
23. MUC18 is involved in cell signaling regulating the expression of Id-1 and ATF-3, thus contributing to melanoma metastasis PMID: 21467165
24. gicerin is an effector for the malignant progression of mammary carcinoma PMID: 14612940
25. Two isoforms of gicerin were generated by an alternative splicing of exon 15 that results in cytoplasmic domains composed of either 63 or 21 amino acids. The mRNA content of gicerin in PC12 cells was regulated by cAMP. PMID: 15769548
26. These findings suggest that TGF-beta1 may therefore regulate gicerin expression in hepatocytes leading to liver regeneration by cell-cell or cell-extracellular matrix interactions. PMID: 17273784
27. These data present direct evidence for the role of CD146 in mediating embryonic attachment and trophoblastic invasion, and provide new insight into the molecular mechanism underlying unexplained pregnancy loss and recurrent miscarriage. PMID: 18288634
28. A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule/MUC18-dependent interaction. PMID: 18922915
29. study identified CD146 as a marker of mouse natural killer cell maturation that is not expressed by other lymphocyte subpopulations PMID: 18958886
30. study concluded that increased moMCAM/MUC18 expression in the two melanoma K1735 sublines minimally affected their tumorigenicity, but it augmented their in vitro motility and invasiveness and increased their pulmonary metastasis in the syngeneic C3H mice PMID: 19010815

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KEGG: mmu:84004

STRING: 10090.ENSMUSP00000034650

UniGene: Mm.275003