Recombinant Mouse Chloride anion exchanger (Slc26a3), partial

1. TNFalpha may act reciprocally with DRA, leading to the development of intestinal inflammation. PMID: 29286110
2. In intestinal cells, TNF activates NF-kappaB, which reduces expression of the Cl(-) / HCO3(-) exchanger SLC26A3, via direct binding to the promoter region. PMID: 28823863
3. This study showed that transepithelial sulfate fluxes across the mouse distal ileum demonstrating that DRA (and to a lesser extent, PAT1) secretes sulfate with significant implications for intestinal sulfate absorption and overall homeostasis. PMID: 28526688
4. expressed in ameloblasts but not alone critical for formation of dental enamel PMID: 26394631
5. DRA surface expression was reduced partly via an increase in DRA endocytosis and a decrease in exocytosis PMID: 26447204
6. Both PAT-1 and DRA significantly contribute to intestinal fluid absorption and enterocyte acid/base balance but are activated by different ion gradients. PMID: 24233434
7. Data demonstrate an upregulation of SLC26A3 via activation of the ERK1/2 pathway that may underlie potential antidiarrheal effects of Bifidobacterium sp. PMID: 25143346
8. Data indicate that solute carrier family 26, member 3 protein (Slc26a3) is expressed in male reproductive tract, and its expression pattern is related to the function. PMID: 25297603
9. Deletion of DRA results in severely reduced colonic HCO3 (-) secretory rate, a loss of colonic fluid absorption, a lack of a firmly adherent mucus layer and a severely reduced colonic mucosal resistance to dextran sodium sulphate damage. PMID: 24373192
10. Efficacy of lactobacillus acidophilus or its secreted soluble factors in alleviating inflammation and inflammation-associated dysregulation of DRA activity could justify their therapeutic potential in inflammatory diarrheal diseases. PMID: 25059823
11. DRA mediates a predominance of the apical uptake of oxalate and Cl(-) absorbed in the small and large intestine of mice under short-circuit conditions. PMID: 23886857
12. Endogenous and recombinant human/mouse Slc26a3 do not exhibit electrogenic 2Cl-/1HCO- exchange. Acute induction of Slc26a3 Cl-/HCO3- exchange is associated with secondary membrane potential changes representing homeostatic responses. PMID: 21068358
13. demonstrate that the double-mutant mice present with a defect in intestinal water absorption and that Hnf1alpha and beta directly control the expression of Slc26a3. PMID: 20388655
14. Increase in DRA promoter activity and expression may contribute to the upregulation of intestinal electrolyte absorption and might underlie the potential antidiarrheal effects of Lactobacillus acidophilus. PMID: 20044511
15. In Slc26a6-knockout mice, a robust Slc26a3 compensatory upregulation can replace the function of Slc26a6 in pancreatic ducts. PMID: 16901991
16. slc26a3 is the major apical chloride/base exchanger and is essential for the absorption of chloride in the colon. In addition, slc26a3 regulates colonic crypt proliferation. PMID: 17001077
17. Dra activity contributes most basal HCO(3)(-) secretion and approximately 50% of cAMP-stimulated HCO(3)(-) secretion in duodenum PMID: 19121635

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KEGG: mmu:13487

STRING: 10090.ENSMUSP00000001254

UniGene: Mm.490454