Recombinant Mouse Collagen alpha-1 (III) chain (Col3a1), partial

1. Results show that COL1A1 and COL3A1 expression is up-regulated in Schistosoma japonicum-induced liver fibrosis. Furthermore, miR-29b directly targets COL1A1 and COL3A1 through binding to their 3'UTR. PMID: 29091295
2. findings suggest that deficiencies of leucine and isoleucine reduce type I and III tropocollagen syntheses in skin by suppressing the action of mTOR PMID: 29191093
3. osthole could inhibit the collagen I and III expressions and their ratio in CFs treated with TGF-beta1 via Smad signaling pathway, which might be one of its anti-fibrotic action mechanisms. PMID: 27870967
4. The findings indicate the critical role of CatB in regulating the expression of collagens III and IV by fibroblasts via prolonging TLR2/NF-kappaB activation and oxidative stress. PMID: 27648120
5. Tsk2 expressing mice harbor numerous autoantibodies in their plasma, including some which are similar to antinuclear antibodies present in systemic sclerosis patients. PMID: 16081813
6. Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis. PMID: 24820199
7. Procollagen type III amino-terminal propeptide increases with left ventricular dilation and decreases with improvement in systolic function in paediatric dilated cardiomyopathy, indicating a role as a biomarker of cardiac remodelling in children. PMID: 24192074
8. Tsk2 point mutation is the first documented gain-of-function mutation associated with Col3a1, which leads instead to fibrosis. PMID: 25330296
9. Col3 plays a role in development of trabecular bone through its effects on osteoblast differentiation PMID: 24626604
10. Type I collagen turnover is critical to large pulmonary artery remodeling during hypoxic pulmonary hypertension when collagen metabolism is not mutated and type III collagen may serve as a reserve. PMID: 23377784
11. Our findings demonstrated the extreme sensitivity of Col3a1 insufficient mice to prematurely develop thoracic aortic ruptures in response to AngII and its associated high levels in BP. PMID: 23630948
12. a possible common pathological pathway linking connective tissue diseases and brain malformations PMID: 22235340
13. Data show that that Col3a1 null mutant mice exhibit overmigration of neurons beyond the pial basement membrane and a cobblestone-like cortical malformation similar to the phenotype seen in Gpr56 null mutant mice. PMID: 21768377
14. Diminished type III collagen promotes myofibroblast differentiation and increases scar deposition in cutaneous wound healing PMID: 21252470
15. Spontaneous deletion in the promoter region and exons 1-39 of the murine Col3a1 locus has produced a relevant and exploitable model of the vascular dissection in vascular Ehlers-Danlos syndrome. PMID: 21071432
16. Data indicate that COL3A1 intronic miRNAs may regulate the expression of other collagen genes in development. PMID: 21268075
17. Transcriptional activation in Tsk2/+ dermal fibroblasts. PMID: 12659831
18. This study shows the presence of collagen types I, III, and V in the endometrial stroma of implantation and interimplantation sites from days 5 to 8 of pregnancy in the mouse. PMID: 17453912
19. alterations in procollagen expression (specifically 1alpha1 and 3) may contribute to a pattern of collagen deposition in the mid-gestational fetuses that is more favorable for scarless healing with less type 1 and more type 3 collagen. PMID: 17950069
20. decreased expression in late-gestational fibroblasts PMID: 19560165

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KEGG: mmu:12825

STRING: 10090.ENSMUSP00000085192

UniGene: Mm.249555