Recombinant Mouse 11-beta-hydroxysteroid dehydrogenase 1 (Hsd11b1), partial

1. exercise training increases pulmonary expression of 11beta-HSD1, thus contributing to local glucocorticoid activation and suppression of pulmonary inflammation in obese mice PMID: 28663379
2. study demonstrates that glucocorticoid-induced insulin resistance was dependent on 11beta-HSD1, resulting in the critical activation of JNK signaling in adipocytes. PMID: 27841334
3. findings indicate that 11b-HSD1 regenerated glucocorticoids in the forebrain and decreased levels of Brain Derived Neurotrophic Factor in the hippocampus play a role in spatial memory deficits in aged wild-type mice. PMID: 27859809
4. 11beta-HSD1 protein expression after caloric restriction was significantly up-regulated, while no difference was detected after re-feeding. Interestingly, upregulation of protein after CR (1.4-fold) was lower than the increase in enzymatic activity (2.6-fold). PMID: 28254522
5. The present study shows the temporal localisation of 11beta-HSD1 in uterus, highlighting its importance in the timing of gestation and suggesting its contribution in the myometrium contraction. PMID: 28237720
6. 11beta-HSD1 deficiency in myeloid phagocytes promotes angiogenesis. PMID: 28676523
7. These data identify suppression of CXCL2 and CXCL5 chemoattractant expression by 11beta-HSD1 as a novel mechanism with potential for regulation of neutrophil recruitment to the injured myocardium, and cardiac fibroblasts as a key site for intracellular glucocorticoid regeneration during acute inflammation following myocardial injury. PMID: 28522730
8. Brown adipose tissue (BAT) from aged 11beta-HSD1 KO mice showed elevated UCP1 protein and mitochondrial content, and a favorable profile of BAT function. PMID: 28368470
9. 11beta-HSD1-deficient mice are not protected from metabolic disease or hepatosteatosis in the face of a nonalcoholic fatty liver disease-inducing diet. PMID: 27384305
10. 11beta-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation. PMID: 27578244
11. these data suggest that corticosterone activation by 11beta-HSD1 in keratinocytes suppresses hapten-induced irritant dermatitis through suppression of expression of cytokines PMID: 27070821
12. Nr3c2 has a role in mouse skin development in a process that involves HSD11B1/HSD11B2 PMID: 26268211
13. Loss of 11beta-HSD1 is associated with hepatocellular carcinoma. PMID: 26700460
14. Data (including data from knockout mice studies) suggest expression of 11bHSD1 (in cardiomyocytes, vascular smooth muscle, other cells) promotes infarct expansion/ventricular remodeling after myocardial infarction & limits angiogenesis/infarct repair. PMID: 26465199
15. Our results demonstrate an inhibitory effect of IGF-I on 11beta-HSD1 expression and activity within the pancreatic islets, which may mediate part of the IGF-I effects on cell proliferation, survival and insulin secretion PMID: 26305481
16. elevated in livers of offspring of restraint-stressed mothers PMID: 25708481
17. Data indicate that 11beta-HSD1 activity contributes substantially to diurnal and stress-induced increases in hippocampal CORT levels. PMID: 25614240
18. Dynamic increases in hippocampal 11b-HSD1 regenerated CORT levels during learning and retrieval play a key role in age- and stress-associated impairments of spatial memory. PMID: 25109766
19. Data suggest that Hsd11b1 expression is up-regulated in white adipose tissues of obese mice; this induction of Hsd11b1 appears to reduce mitochondrial respiration and adiponectin synthesis in hypertrophic adipocytes. PMID: 25869616
20. Data suggest that Gh (growth hormone) represses H6pd (hexose-6-phosphate dehydrogenase) through locally produced Igf1 (insulin-like growth factor 1); Gh directly represses Hsd11b1 mRNA rather than acting via Igf1 receptor. PMID: 24759003
21. Elevated adipose 11beta-HSD1 expression may contribute to glucocorticoid-induced insulin resistance and adipolysis. PMID: 25389364
22. 11beta-HSD1, particularly in adipose tissue, is key to the development of the adverse metabolic profile associated with circulating glucocorticoid excess PMID: 24889609
23. The possibility of a vicious circle of glucocorticoids signals via 11beta-HSD1 up-regulation in adipose tissues, contributing to deterioration of glucose metabolism to result in diabetes. PMID: 24511146
24. Elevated hepatic 11betaHSD1 is an important contributor to early insulin resistance and dyslipidemia in uremia. PMID: 24569863
25. TNFalpha-mediated Hsd11b1 binding of NF-kappaB p65 is associated with suppression of 11beta-HSD1 in muscle cells. PMID: 24413279
26. Oxidoreduction of 7-oxolithocholic acid and its conjugated metabolites are catalyzed by 11beta-HSD1. PMID: 23933573
27. These data challenge the concept that inhibition of 11beta-HSD1 is likely to produce a "step-change" treatment for diabetes and/or obesity. PMID: 24169553
28. 11beta-HSD1 expression is down-regulated during adipose tissue expansion in diet-induced obese mice. PMID: 23512810
29. 11beta-HSD1 can inter-convert 7-KC and 7betaOHC in the arterial wall PMID: 22940536
30. 11beta-HSD1 expression was decreased in TPA-treated hyperproliferative skin. PMID: 23362866
31. 11beta-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE knockout mice. PMID: 23383297
32. These findings suggest that 11b-HSD1-generated glucocorticoids may tonically restrain mast cell degranulation, potentially influencing allergic, anaphylactic and inflammatory responses. PMID: 23349944
33. 11beta-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature. PMID: 23170035
34. Our results indicate that 11beta-HSD1 acts as a vital regulator that controls the expression of genes related to brown fat function and as such may become a potential target in preventing obesity PMID: 23197361
35. Ifi202b modulates fat accumulation through expression of adipogenic genes such as 11beta-Hsd1. PMID: 22692684
36. 11beta-HSD1 may be a very promising therapeutic target for obesity and associated disease. PMID: 22768329
37. mice with liver-specific disruption of 11beta-hydroxysteroid dehydrogenase type 1 lack significant metabolic abnormalities PMID: 22555437
38. High-fat diet accelerated aging in the liver of SAMP10 mice by increasing liver mRNA level for Hsd11b1, increasing insulin secretion, and promoting lipid accumulation in the liver. PMID: 22033707
39. knockdown of 11beta-HSD1 can protect against several western type diet-induced metabolic abnormalities. These effects are, at least in part, mediated by increases in the oxidative capacity of brown adipose tissue. PMID: 22209663
40. These studies delineate a novel pathway that links hormonal and circadian signals to gluconeogenesis and glucose homeostasis. PMID: 22447855
41. Reduced intra-adipose glucocorticoid regeneration by 11beta-HSD1 is a novel mechanism that contributes to the metabolic efficacy of salicylates. PMID: 22357964
42. Optimal elevation of beta-cell 11beta-HSD1 represents a novel biological mechanism supporting compensatory insulin hypersecretion rather than exacerbating metabolic disease. PMID: 22315313
43. adipose tissues of 11betaHSD1(-/-) mice exhibit attenuated hypoxia, induction of hypoxia-inducible factor (HIF-1alpha) activation of the TGF-beta/Smad3/alpha-smooth muscle actin (alpha-SMA) signaling pathway, and fibrogenesis PMID: 22158867
44. 11beta-HSD1-deficient mice showed greater numbers of inflammatory cells in pleural lavages in carrageenan-induced pleurisy with lung pathology consistent with slower resolution, suggesting that 11beta-HSD1 limits acute inflammation. PMID: 22067318
45. tissue- and differentiation state-specific promoter usage in expression of human HSD11B PMID: 21215738
46. 11beta-HSD1 controls glucocorticoid-induced protein degradation in human and murine skeletal muscle via regulation of the E3 ubiquitin ligases Atrogin-1 and MuRF-1. PMID: 21304964
47. 11beta-HSD1 deficiency in aging mice leads to lower intracellular GC concentrations in brain, particularly in the hippocampus, which activate predominantly MRs to enhance memory PMID: 21411659
48. Demonstrated that remarkable pharmacokinetic differences existed between high-fat diet-induced obese and lean mice for HSD11B1 inhibitors. PMID: 21198436
49. These data are consistent with an 11beta-HSD1-independent function for H6PDH in which sarcoplasmic reticulum G6P metabolism and NAD/NADH redox status are important for maintaining muscle homeostasis. PMID: 21106871
50. Inflammatory cell recruitment after myocardial infarction is modified in mice deficient in 11bHSD1 and this provides an enhanced stimulus for angiogenesis in the healing infarcts of these mice. PMID: 20495186

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KEGG: mmu:15483

STRING: 10090.ENSMUSP00000016338

UniGene: Mm.28328