Recombinant Mouse Cytosolic carboxypeptidase 6 (Agbl4)

Code CSB-YP600702MO
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Source Yeast
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Code CSB-EP600702MO
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Source E.coli
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Code CSB-EP600702MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP600702MO
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Source Baculovirus
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Code CSB-MP600702MO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Agbl4
Uniprot No.
Alternative Names
Agbl4; Ccp6; Cytosolic carboxypeptidase 6; EC 3.4.17.-; ATP/GTP-binding protein-like 4
Species
Mus musculus (Mouse)
Expression Region
1-540
Target Protein Sequence
MAERSQTAPE AGNDTGNEDA IGGNVNKYIV LPNGYSGQPK KGHLTFDACF ESGNLGRVEQ VSDFEYDLFI RPDTCNPRFR VWFNFTVENV KELQRVIFNI VNFSKTKSLY RDGMAPMVKS TSRPKWQRLP PKNVYYYRCP DHRKNYVMSF AFCFDREDDI YQFAYCYPYT YTRFQHYLDS LQKKNMDYFF REQLGQSVQQ RQLDLLTITS PENLREGSEK KVIFITGRVH PGETPSSFVC QGIIDFLVSQ HPIARVLREH LVFKIAPMLN PDGVYLGNYR CSLMGFDLNR HWLDPSPWAH PTLHGVKQLI IKMYNDPKTS LEFYIDIHAH STMMNGFMYG NIFEDEERFQ RQSIFPKLLC QNAEDFSYTS TSFNRDAVKA GTGRRFLGGL LDHSSYCYTL EVSFYSYIIG GTTAAVPYTE EAYMKLGRNV ARTFLDYYRL NSLVEKIAVP MPRLRSKEER RLGWEHPSCL RAEQPLEVLG IPMCSGKALN EHLGNDIQWH LDCGSSTLPL GLISCSPSSS ASWNDMAMSN SILLPDHSFH
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.
Gene References into Functions
  1. study shows that Mad2 is a novel substrate for CCP6 in megakaryocytes; Mad2 polyglutamylation plays a crucial role in the regulation of megakaryopoiesis PMID: 25332286
Subcellular Location
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Cytoplasm, cytoskeleton, cilium basal body.
Protein Families
Peptidase M14 family
Tissue Specificity
Widely expressed. Expressed abundantly in testis, pituitary and brain and to a lower extent in eye, stomach, adrenal and kidney. In brain, expressed at low level in cerebellum as compared to cortex.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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