Recombinant Mouse D-amino-acid oxidase (Dao)

1. This work provides the most complete baseline analysis of L- and D-amino acids in the brains of wild-type and mutant mice lacking D-amino acid oxidase activity. PMID: 29532193
2. findings reveal that DAO is a microbiota-regulated host innate immune factor that modulates growth of both pathogens and commensals, primarily in the small intestine PMID: 27670111
3. some significant in vivo effects of DAOR199W on motor neuron function (i.e. kyphosis and loss of motor neurons) were detected which were most marked in females and could contribute to the earlier onset of neurological signs in double transgenic females compared to SOD1G93A littermates, highlighting the importance of recognizing gender effects present in animal models of ALS PMID: 29194436
4. Long-term spatial memory is unaltered in Dao-/- mice. PMID: 26833794
5. Dao-/- mice demonstrated enhanced spatial recognition memory and no sleep or circadian rhythm disruption. PMID: 25816902
6. In d-Amino acid oxidase (-/-) mice, approximately twice as many Dopamine-like neurons fired in a bursting pattern than in DAO(+/-) or DAO(+/+) mice. Data provide the first direct evidence that DAO modulates VTA DA neuron activity PMID: 25040393
7. The retinal levels of d-serine are tightly controlled during the first week of postnatal life and vary according to deficiencies in either DAO/ PMID: 25083578
8. DAO deficiency reduces D-serine level in retina and increases NMDA receptor expression. PMID: 24068757
9. D-amino acids and DAO have pivotal neurotransmission functions in the central nervous system. (Review) PMID: 22892863
10. D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects. PMID: 22802136
11. results suggest that DAO, together with myeloperoxidase, may play an important role in antibacterial systems in mammals PMID: 22271930
12. DAO has a pivotal role in motoneuron degeneration through D-serine regulation, with inactivity of DAO being a common feature between the mSOD1 ALS mouse model and mutant DAO-associated familial ALS. PMID: 22203986
13. Results confirm the role of D-amino acid oxidase (DAO) in D-serine metabolism, and provide a tool to investigate DAO, an enzyme currently of considerable interest in the pathophysiology and therapy of schizophrenia. PMID: 20828614
14. data show enhanced PPI responses and enhanced PPI-disruptive effects of NMDA antagonists in DAO-/- mice . PMID: 20933022
15. Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase PMID: 20368421
16. Hypofunctional Dao 1 mutation elevated brain levels of D-serine. Mice with both Dao1 and Grin 1 mutations had improved social approach spatial memory retention, reversal of latent inhibition, and partial normalized startle responses. PMID: 19751394
17. These results suggest that the abundant D-amino-acids in the mutant mouse brain facilitate hippocampal LTP and spatial learning. PMID: 15996778
18. Lacks DAO activity and shown for the first time it has increased occupancy of the NMDAR glycine site due to elevated extracellular D-serine levels and has enhanced NMDAR function in vivo. PMID: 16843004
19. Its physiological role is in metabolizing endogenous and exogenous D-amino acids. PMID: 18516913
20. D-amino acid oxidase may be a promising therapeutic target to improve cognitive flexibility and inhibitory learning in psychiatric disorders such as schizophrenia and anxiety syndromes. PMID: 19117914

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KEGG: mmu:13142

STRING: 10090.ENSMUSP00000107911

UniGene: Mm.20115