Recombinant Mouse DNA- (apurinic or apyrimidinic site) lyase (Apex1)

1. We suggest that serum APE1/Ref-1 can be used to assess for myocardial injury in viral myocarditis without endomyocardial biopsy PMID: 29292734
2. AOM, a colorectal cancer carcinogen, generates damage to the mitochondrial genome, and the BER enzyme APE1 is required to maintain its integrity. PMID: 28360037
3. findings provide evidence that endogenous APE1 protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury PMID: 27274063
4. Suppression of Ape1/Ref-1 redox function leads to an increased cell surface retention of IL-12 and enhances Th1 responses. PMID: 27637330
5. Is closely associated with upregulation of the Ref1/Nrf2 signalling pathway. PMID: 26682532
6. Results show the stimulatory effect of PARP-1 on APE1-dependent base excision repair (BER). PARP-1 and APE1 appear to have a functional interaction in BER since PARP-1 can stimulate the strand incision activity of APE1. PMID: 26020771
7. increases in APEX1 level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells PMID: 26201249
8. Endothelial cell tumor proliferation was found to be dependent on Apex-1 expression. PMID: 26108661
9. Expression of OGG1 and APEX1 was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity. PMID: 25113976
10. Data indicate that the endonuclease activity of APE1 is required for class switch recombination (CSR). PMID: 25404348
11. These results suggest that mitochondrial APE1/Ref-1 is contributed to the protective role to protein kinase C-induced mitochondrial dysfunction in endothelial cells. PMID: 24861944
12. Spinal motor neurones down-regulate APE1 upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions. PMID: 23808792
13. The reductive activation of endothelial SIRT1 by APE1/Ref-1 mediates the effect of APE1/Ref-1 on eNOS acetylation, promoting endothelium-derived NO and endothelium-dependent vasorelaxation. PMID: 23755229
14. Together, these data show that the expression of APE1 is crucial for efficient transcription of ribosomal genes. PMID: 24648491
15. Ape1, an enzyme required for processing apurinic/apyrimidinic (known as abasic) sites, is also involved in the generation of small DNA fragments during DNA repair. PMID: 25210033
16. Voluntary running wheel exercise significantly increases levels of BDNF, activates CREB, and upregulates APE1 in the cerebral cortex and hippocampus of mice. PMID: 24114393
17. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 and up-regulation of APE2 expression in germinal center B cells. PMID: 24927551
18. Transient OGG1, APE1, PARP1 and Polbeta expression in an Alzheimer's disease mouse model. PMID: 24121118
19. APE1 enhances in vivo vascular repair effects of endothelial progenitor cells in part through the maintenance of adhesion properties of EPCs during oxidative stress. PMID: 23934858
20. Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 in individual morula embryos. PMID: 23154201
21. Energy failure-induced Ape1 depletion triggers neuronal death in ischemic brain injuries. PMID: 22841870
22. the mouse-renin gene is regulated by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex PMID: 22441348
23. these findings are the first demonstration that Ape1/Ref-1 is an indispensable molecule for the IL-21-mediated signal transduction through ERK1/2 activation. PMID: 22450323
24. Mutant frequency and nuclear DNA damage increased earlier in spermatogenic cells from Apex1(+/-) mice (by 6 months of age). By old age, mutant frequencies were similar for wild-type and APEN-deficient mice. PMID: 21919107
25. APE1 suppresses oxLDL-induced p66shc activation in endothelial cells by inhibiting PKCbetaII-mediated serine phosphorylation of p66shc, and mitigates vasoconstriction induced by activation of PKC. PMID: 21467074
26. Data show that Mad2 haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 inhibitor in vitro. PMID: 21216274
27. These findings suggest that cell death is initiated by reducing APE/Ref-1 protein and inhibiting its repair function. PMID: 20637286
28. Cytoplasmic Ape1 could enhance lung tumor malignancy through NF-kappaB activation. PMID: 20498636
29. The stoichiometry of base excision repair enzymes is one critical factor underlying the tissue selectivity of somatic CAG expansion. PMID: 19997493
30. study indicates that IL-6 induces a novel STAT3-APE1 complex, whose interaction is required for stable chromatin association in the IL-6-induced hepatic acute phase response PMID: 20032196
31. Data show that the rabbit anti-human APE1 polyclonal antibody with high titer and specificity can be used not only to elucidate the roles of APE1 protein in cellular procedures, but also to detect the expression of the APE1 protein in mice and rats. PMID: 19351502
32. indicates that Apex1 can generate complex double strand breaks from clustered lesions consisting of base damage and abasic sites. PMID: 19800300
33. promoter regions and tissue distribution of APEX PMID: 12200116
34. Il-2 induction of ref-1 protein may be involved in the regulation of telomerase activity. PMID: 12647295
35. Ref-1 has a role in redox regulation of AP-1 DNA binding PMID: 12773568
36. Brain expression of apurinic/apyrimidinic endonuclease (APE/Ref-1) multifunctional DNA repair enzyme gene in the mouse with special reference to the suprachiasmatic nucleus. PMID: 12871766
37. changes in base excision repair activity correlated tightly with changes in DNA polymerase beta and Apurinic/apyrimidinic site DNA binding levels PMID: 14973123
38. diminution of AP endonuclease has a significant effect on spontaneous mutagenesis in somatic and germ line cells PMID: 15340075
39. A novel physiological role for APE1/ref-1 in regulating vascular tone by governance of eNOS activity and bioavailable NO. PMID: 15472121
40. Results indicate that the DNA repair and gene regulation functions of APE1 are essential and provide evidence that mammalian cells require APE for survival, presumably to protect against spontaneous oxidative DNA damage. PMID: 15824325
41. In sum, loss of a single allele of Ref-1 is sufficient to reduce intimal lesion formation and to alter circulating cytokine and growth factor expression. PMID: 16936011
42. Ape1 is critical in normal embryonic hematopoietic development PMID: 17053053
43. The ATF4-mediated up-regulation of Ape1 and other genes plays a key role against arsenite-mediated toxicity and mutagenesis. PMID: 17938202
44. Both APE1 and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination. PMID: 18025127
45. In hepatocytes, ablation of p66(shc) is cytoprotective against hypoxia/reoxygenation-induced oxidative stress, with MnSOD, Ref-1, and Bcl-xL up-regulated, and FLICE down-regulated. PMID: 18191273
46. Apex1 makes fine-tuning of CD40-induced B cell proliferation. PMID: 18617267
47. Inhibition of the redox function of APE1 blocks murine endothelial cell growth and angiogenesis, and blocks the growth of human tumor cell lines. These effects are independent of the APE1 DNA-repair function. PMID: 18627350
48. By 1 month of age, genomic instability increases in livers of Mat1a knockout mice, possibly due to reduced APEX1 levels PMID: 18983843
49. increased APE/Ref-1 enhanced DNA repair and inhibited the induction of ischemic oxidative DNA damage and cerebral infarction after ischemia/reperfusion PMID: 19374886

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KEGG: mmu:11792

STRING: 10090.ENSMUSP00000042602

UniGene: Mm.203