Recombinant Mouse DNA-binding protein inhibitor ID-2 (Id2)

1. It is anegative master modulators of oligodendrocyte differentiation. PMID: 29689424
2. ID2 is a key mediator of progesterone, which drives luminal lineage differentiation and side branching. PMID: 29950389
3. phosphorylation of Id2 modulates the degradation of this important cell-cycle regulator. PMID: 26756672
4. the expression of the transcriptional regulator Id2 is downregulated upon stimulation of invariant natural killer T cells with their cognate antigen. PMID: 26880074
5. data reveal a previously unrecognized STAT3-mediated immunosuppressive mechanism in DCs and indicate that DC-intrinsic ID2 promotes tumor immunity by modulating tumor-associated CD4(+) T cell responses. PMID: 27678219
6. Our work identifies a distinct premalignant state and multiple tumorigenic pathways caused by loss of function of Id2 and Id3 PMID: 28258199
7. Id2 is an important molecular mediator of labyrinthine trophoblast differentiation. PMID: 27168216
8. Zeb2 regulates commitment to both the cDC2 and pDC lineages through repression of Id2. PMID: 27185854
9. The authors show that Id2 restricts the activity of the Wnt signalling pathway at early stages and prevents precocious differentiation of the embryonic intestinal epithelium. PMID: 28077488
10. Reduced core body temperature was found in Id2-/- mice. Moreover, in Id2-/- brown adipose tissue, 30 genes including Irs1, PPARs, and PGC-1s were identified as differentially expressed in a sex-specific pattern. PMID: 27144179
11. this study identifies a role for the E-protein inhibitor Id2 in promoting TH1 cell polarization over follicular T cell polarization PMID: 27213691
12. ID2 is required not only to antagonize E-proteins during NK cell commitment, but constantly required to titrate E-protein activity to regulate NK cell fitness and responsiveness to IL-15. PMID: 26795246
13. Data show that knock down of inhibitor of differentiation protein 2 (Id2) attenuates neuroblastoma tumor cells and induces host immunity. PMID: 26079374
14. overexpression of Id2 in primary alveolar epithelial cells promotes proliferation by inhibiting a retinoblastoma protein/c-Abl interaction leading to greater c-Abl activity. PMID: 25661109
15. Innate lymphoid cells can mediate immune surveillance, which constantly maintains a proper microbiota, to facilitate early colonization resistance through an ID2-dependent regulation of IL-22. PMID: 25902484
16. a distinct pattern of hepatic lipid accumulation was observed in Id2-/- males: low lipids on the low-fat diet and steatosis on the high-fat diet. PMID: 25108156
17. Id2 and Id3 enforce follicular regulatory T-cell checkpoints and control the maintenance and homing of Regulatory T cells. PMID: 24973820
18. Id2 represses E2A-mediated activation of IL-10 expression in T cells. PMID: 24723679
19. Data suggest that elevated Id2 expression in embryonic brains can cause deregulated NSC self-renewal, differentiation, and survival that manifest in multiple neurological outcomes in mature brains, including microcephaly, seizures, and brain tumors. PMID: 23390122
20. expression of the negative regulators of E proteins, Id2 and Id3, defined distinct iNKT cell sublineages. PMID: 24470501
21. a role for ID2 as a regulator of glucose and lipid metabolism and in the circadian control of feeding/locomotor behavior PMID: 24023810
22. Id2 is the major modifier of Id3 in limiting Vgamma1.1(+)Vdelta6.3(+) T cell expansion. Conditional knockout of Id2 alone is sufficient to promote a moderate expansion of gammadelta T cells. PMID: 24379125
23. ID2 and ID3 redundantly promoted iNKT cell lineage specification involving the induction of the signature transcription factor PLZF. ID2 limited iNKT cell numbers by enforcing the postselection checkpoint in conventional thymocytes. PMID: 24244015
24. It was proposed that Id2 expression in the suprachiasmatic nucleus contributes to maintenance of dynamic circadian oscillations. PMID: 24320178
25. Irf8 expression in DC9 cells led to an increase in Id2 transcript levels.When coexpressed with Irf8, Batf3 & Id2 had a synergistic effect on classical CD8alpha(+) DC development. PMID: 24227775
26. Deletion of Id2 and Id3 in T cell progenitors resulted in a partial block at the pre-TCR selection checkpoint and a dramatic increase in numbers of iNKT cells. PMID: 24123680
27. Expression of transcription factor, inhibitor of DNA-binding protein, a critical factor for natural killer cell development, is impaired in Mysm1-/- NK cells. PMID: 24062447
28. Findings indicate a function for Id2 in regulating Snai1-mediated repression of integrin beta4. PMID: 23878399
29. These findings document a novel role for Id2 in the maintenance of midbrain dopamine neurons. PMID: 23264561
30. Id2-deficient CD8(+) T cells fail to induce sufficient Tbx21 expression. PMID: 23536629
31. Authors describe a role for Id2 in both the survival and differentiation of normal CD8 effector and memory populations. PMID: 23325888
32. STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. PMID: 23033267
33. These data suggest a model whereby E protein transcription factor activity favors rapid memory-precursor T-cell formation while their negative regulators, Id2 and Id3, are both required for robust effector CD8( ) T-cell response during infection. PMID: 22585759
34. Deficiency in Id2 or Id3 resulted in loss of distinct CD8(+) effector and memory populations. PMID: 22057289
35. Data suggest that JunB contributes to Id2 repression and provides important input in setting the transcriptional program of the EMT and profibrotic responses to TGF-beta. PMID: 22391036
36. Both the expression of Id2 and Notch are required for the generation of alpha4beta7(+) RORgammat(-) fetal progenitors, but Notch subsequently blocks progression to the RORgammat(+) stage and final maturation of lymphoid tissue inducer cells PMID: 22430492
37. BMP signaling is primarily responsible for the serum-induced Id2 expression. PMID: 22421219
38. Data show that spatially-restricted growth defects are localized at the skull base of Id2 KO mice. PMID: 21985998
39. A role for Id2 in the second heart field contribution at both the arterial and the venous poles of the heart. PMID: 22012595
40. CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell PMID: 22041901
41. nuclear retention of Id2 due to RANK signaling plays a decisive role in the survival and differentiation of mammary epithelial cells during mammary gland development PMID: 21947283
42. Id2 may be a novel target for enhancing sensory axonal regeneration following injuries to the adult spinal cord. PMID: 21679705
43. Long-term treatment of lower dosage lipopolysaccharide mainly causes upregulation of Id2 protein. PMID: 21110107
44. Id2 expression delineates differential checkpoints in the genetic program of CD8alpha+ and CD103+ dendritic cell lineages. PMID: 21587207
45. Results demonstrate that high expression levels of Mad3 in immature B cells induce Id2 expression, which inhibits transcription of genes essential for B cell differentiation. PMID: 20375148
46. BMP-responsive elements in mouse Id2 and CGCC sequence that contributes to target recognition by Smad proteins were identified. PMID: 20674548
47. Data demonstrate that benzo(a)pyrene activates PRKAA1/2 and causes ID2 protein loss in trophoblast stem cells in a time- and dose-dependent manner. PMID: 20422711
48. Data observed physical interactions between Id1, Id2, or Id3 and SMAD3. The data suggest that BMP2 synergistically regulates Fshb transcription with activins, at least in part, through the combined actions of Ids 2 or 3 and SMAD3. PMID: 20463050
49. Liver metastases in Id2 heterozygotes demonstrated significant decrease of Id2 expression and loss of the remaining Id2 allele, strongly suggesting that Id2 inactivation specifically was required for metastasis in this model PMID: 20127274
50. Hypoxia-induced ID-2 may contribute to joint destruction in rheumatoid arthritis patients by promoting synovial fibroblast-dependent osteoclastogenesis. PMID: 19950294

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KEGG: mmu:15902

STRING: 10090.ENSMUSP00000020974

UniGene: Mm.34871