Recombinant Mouse Dentin matrix acidic phosphoprotein 1 (Dmp1)

1. This study provides a new understanding of DMP1's function in regulation of osteogenesis: not only an enhancer of bone formation, but also a negative regulator of mesenchymal stem cell differentiation in bone. PMID: 29775615
2. Findings support the critical role of DMP1 in maintaining the integrity of the auditory ossicles and its bony membrane PMID: 28603080
3. Results show that transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice and suggest that DSPP and DMP1 may function synergistically within the complex milieu of bone matrices. PMID: 26686820
4. Nestin(+) cells are one important type of progenitor cell in bone marrow and are associated with bone remodeling. These data indicate that DMP1 plays negative roles in differentiation of Nestin(+) cells and bone formation. PMID: 28647374
5. mutation creates a lower set point for extracellular phosphate and maintains it through the regulation of Fgf23 cleavage and expression PMID: 28005411
6. Data show that the phenotype of Notch activation in osteocytes was prevented in matrix protein 1 (Dmp1)-Cre;Rosa(Notch) mice hemizygous for the Dmp1-sclerostin (SOST) transgene. PMID: 26456319
7. Klf10 is involved in tooth development and promotes odontoblastic differentiation via the up-regulation of Dmp1 and Dspp transcription. PMID: 26310138
8. These findings indicate that glycosylation of DMP1 is a key posttranslational modification process during development and that DMP1-PG functions as an indispensable proteoglycan in osteogenesis. PMID: 26634432
9. the hypophosphatemia induced osteomalacia phenotype in Dmp1 KO mice is contributed by at least two factors: the low Pi level and the DMP1 local function in mineralization PMID: 26303287
10. These results suggest that the LPV motif is essential for the efficient export of secretory DMP1 from the ER to the Golgi complex. PMID: 26595451
11. An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. PMID: 26428891
12. It was concluded that endogenously secreted PTH and GHR signaling in bone are necessary to establish radial bone growth and optimize mineral acquisition during growth. PMID: 26481310
13. This study demonstrates the sequential involvement of Wnt5, MMP-3, DMP-1 expression, and DMP-1 degradation products by MMP-3, in effecting IL-1beta-induced proliferation of ESC-derived odontoblast-like cells. PMID: 26355224
14. We conclude that DMP-1 may be involved in regulating the temporal expression at embryonic stages in the mouse tongue PMID: 25978185
15. downregulation by PTH and vitamin D via the cAMP/PKA pathway PMID: 26276370
16. bone-specific Dentin matrix protein 1 overexpression changes the pattern in osteogenic gene expression pattern thereby influencing bone development PMID: 25158195
17. identify alternative splicing as a mechanism utilized by cancer cells to modulate the DMP1 locus through diminishing DMP1alpha tumour suppressor expression PMID: 25537728
18. These results indicated that the downregulation of Dmp1 may not directly associate with, or significantly contribute to the bone and dentin defects in the Fam20C-cKO mice. PMID: 24874551
19. DMP1 may play an important role in maintaining the chondrogenic phenotype and its possible involvement in altered cartilage matrix remodelling and degradation in disease conditions like osteoarthritis. PMID: 24987156
20. data suggest that the full-length DMP1 plays no apparent role in the nucleus during odontogenesis. PMID: 25105818
21. DMP1 continues its expression in osteoblasts during postnatal development and that the deletion of Dmp1 leads to an increase in osteoblast proliferation PMID: 24917674
22. results support the hypothesis that 1,25D regulates DMP-1 expression through a VDR-dependent mechanism, possibly contributing to local changes in bone/tooth mineral homeostasis. PMID: 24334408
23. Klf4 was able to specifically bind to the Dmp1 promoter. PMID: 23558921
24. the differential localization patterns of DMP1 fragments indicate that different forms of DMP1 may play distinct roles in the SMGs. PMID: 23111467
25. DMP1 has a protective role for odontoblasts and ameloblasts in a pro-apoptotic environment (a high Pi level). PMID: 23258378
26. Results indicate that dentin sialophosphoprotein (DSPP) is a downstream effector molecule that mediates the roles of dentin matrix protein 1 (DMP1) in dentinogenesis. PMID: 23349460
27. These findings indicate a functional interaction between PHEX and DMP1 to regulate bone mineralization and circulating FGF23 levels. PMID: 22930691
28. These findings suggest that DMP1 has an anti-apoptotic role in hyperphosphatemia. PMID: 22879941
29. these findings suggest that, apart from its role as a constituent of dentin and bone matrix, DMP1 might play a regulatory role in the nucleus. PMID: 22813642
30. These results indicate a potential role of the full-length form of DMP1 in chondrogenesis. PMID: 21555863
31. PHEX and DMP1 control a common pathway regulating bone mineralization and FGF23 production, the latter involving activation of the FGFR signaling in osteocytes. PMID: 21507898
32. proteolytic processing of DMP1 is essential to the formation and mineralization of dentin, cementum, and jaw bones PMID: 21297011
33. the 57-kDa C-terminal fragment is the functional domain of DMP-1 that controls osteocyte maturation and phosphate metabolism, and affects FGF23 PMID: 20734454
34. distribution of the osteocytic lacunar-canalicular system and osteocyte-secreting molecules--dentin matrix protein 1 and sclerostin--in the epiphyses and cortical bones in osteoprotegerin deficiency PMID: 21079361
35. mutant mice did not recapture phenotype observed in human patient but displayed a mild rachitic tooth phenotype in comparison with that in the Dmp1-null mice, suggesting that the DI III-like phenotype may be due to an as-yet-undetermined gene modifier PMID: 20499360
36. Data reported circling behavior and hyper reaction to touching in Dmp1 null mice PMID: 20877695
37. that the full-length form of DMP1 is an inactive precursor and its proteolytic processing is an activation step essential to the biological functions of this protein in osteogenesis. PMID: 20663874
38. Dmp1 first appeared in hypertrophic cartilage cells, followed by osteoblasts, and later was expressed strongly in osteocytes. Dmp1 may play an important role in bone formation. PMID: 12369786
39. TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts. PMID: 12489180
40. Transcriptional regulation of dentin matrix protein 1 (DMP1) by AP-1 (c-fos/c-jun) factors. PMID: 12489182
41. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralized matrix formation extracellularly, at later stages of osteoblast maturation PMID: 12615915
42. involved in the responses of osteocytes and osteoblasts to mechanical loading of bone PMID: 12733719
43. dentin matrix protein-1 is processed by Bone morphogenetic protein-1/Tolloid-like proteinases PMID: 14578349
44. Dmp-1 null mice postnatally develop a profound tooth phenotype characterized by a partial failure of maturation of predentin into dentin, enlarged pulp chambers, increased width of predentin zone with reduced dentin wall, and hypomineralization PMID: 14966118
45. histone acetyltransferase activity of p300 a critical role in regulating DMP1 gene expression PMID: 15308641
46. DMP1 may have functions other than the regulation of mineralization PMID: 15316863
47. DMP1 is essential for normal postnatal chondrogenesis and subsequent osteogenesis PMID: 15590631
48. 8-kb region of the Dentin matrix protein 1 (DMP1) gene is a target for mechanotransduction in osteocytes, and its cis-regulatory activity may be correlated to local strain in bone PMID: 15728181
49. Dmp mRNA is expressed in developing testis cords, and thus may contribute to testis differentiation PMID: 15937924
50. Dmp1 is the key factor in the formation of growth plates and secondary ossification center, and plays an important role in the process of bone and cartilage formation and bone nodule remodeling. PMID: 16191382

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KEGG: mmu:13406

STRING: 10090.ENSMUSP00000068053

UniGene: Mm.199008