Recombinant Mouse Dual specificity protein phosphatase 6 (Dusp6)

1. 257 genes among 55,681 genes examined were up-regulated after 30-min treatment of GT1-7 cells with GnRH. These up-regulated genes included four dual-specificity MAPK phosphatases (DUSPs), DUSP1, DUSP2, DUSP5, and DUSP6. PMID: 29899190
2. findings suggest that DUSP6 connects TCR signaling to activation-induced metabolic commitment toward glycolysis and restrains TFH cell differentiation via inhibiting IL-21 production. PMID: 30087184
3. mitogen-activated kinase phosphatase-3 overexpression resulted in a significant reduction of hypothalamic FoxO1 phosphorylation after insulin stimulation. PMID: 28866049
4. DUSP6 may be a useful strategy to prevent neuronal death in neurodegenerative diseases. PMID: 28475917
5. This study demonstrates that dusp6 deficiency is a strong genetic factor shaping gut microbiota, and that it confers obesity protection by ameliorating the gut microbiota response to diet-mediated stress. PMID: 27892926
6. DUSP6 deficiency has limited impact on the regulation of energy metabolism, but impairs systemic glucose tolerance. PMID: 28873424
7. Mitogen-activated protein kinase phosphatase 3 upregulation requires the activation of the Erk1/2 pathway, which correlates with the shutdown of this pathway. PMID: 26818088
8. MKP3 could be an important factor in the regulation of brown adipocyte differentiation. PMID: 26325440
9. exercised obese mice had a lower expression of MKP-3 and FoxO1/MKP-3 association in the liver PMID: 24396063
10. c-Myb plays an important role in H-Ras-induced MKP-3 transcription PMID: 24978307
11. Mice lacking MKP-3 protein develop an abnormal persistent state of mechanical allodynia following plantar incision, concurrent with long-lasting spinal phosphorylation of ERK-1/2 and p38. PMID: 24155322
12. Depletion of DUSP6 reduced the viability of cancer cell lines and increased the cytotoxicity of EGFR and other targeted inhibitors, and cytotoxic agents. PMID: 23839489
13. LH/hCG tightly up-regulates MKP-3 which in turn, dephosphorylates ERK1/2 and drives p21 expression. PMID: 23261984
14. Insulin likely promotes MKP-3 protein degradation through activation of MEK/ERK pathway in liver cells. PMID: 22521266
15. DUSP6 and PP2A participate in the regulation of melanogenesis PMID: 22544520
16. DUSP6 is important in melanoma and it plays a different role in the distinct subtype of mouse melanoma compared with that in classic human melanoma. PMID: 22171919
17. The reduced MKP3 expression increased the phosphorylation of Akt and Erk5, and this was correlated with an enhanced cell migration in response to PDGF-BB stimulation. PMID: 22100392
18. ERK cascade can act as a coincidence detector to decode the simultaneous engagement of a receptor tyrosine kinase and of LRP-1 and as a signal integrator that encodes this information in a spatially and temporally distinct biological signal PMID: 21610072
19. Results indicate that Dusp6 is a major regulator of epididymal cell proliferation in the caput and corpus regions (but not in the initial segment). PMID: 20650883
20. mPyst1 messenger RNA is found in important signaling centers associated with cell proliferation and patterning in developing mouse embryos PMID: 11960712
21. cloning and expression analysis during embryogenesis PMID: 12128234
22. MKP3 mediates the cellular response to FGF8 in the mouse limb. PMID: 12766772
23. During mouse limb bud development, Mkp3, a known MAPK/ERK regulator, is induced in the mesoderm by FGF8 signaling, through the PI3/Akt pathway. PMID: 12776124
24. cytoplasmic localization of MKP3 is mediated by a chromosome region maintenance-1 (CRM1)-dependent nuclear export pathway; the ability of MKP3 to cause the cytoplasmic retention of ERK2 requires both a functional kinase interaction motif and NES PMID: 15269220
25. CK2 selectively phosphorylates MKP3, suggesting cross-regulation between CK2alpha and MKP3, as well as a modulation of ERK2-MAPK signaling by CK2alpha via MKP3 PMID: 15284227
26. MKP3 has a negative feedback action on the MAPK/ERK-mediated FGF8 pathway in the mouse neuroepithelium. PMID: 15572144
27. Dusp6 is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development. PMID: 17164422
28. Data show that Dusp6 transcripts is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development. PMID: 18058922
29. In this study, association analyses were preformed in silico between the variation I62M (rs13480726) of the Dusp6 (Mkp3) gene and the mouse forebrain weight/structure in 385 mice of 20 strains. PMID: 18344456
30. WT1 transactivates another important negative regulator of the Ras/MAPK pathway, MAPK phosphatase 3 (MKP3). PMID: 18644985
31. The molecular basis of DUSP6 gene expression in undifferentiated state of ES cells is highly conserved during evolution. PMID: 19032937
32. cellular microglial pathway triggered by CBR2 activation; reduction of pro-inflammatory factors and microglial migration via MKP-3 induction is part of the mechanism of action of CBR2 agonists PMID: 19476641

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KEGG: mmu:67603

STRING: 10090.ENSMUSP00000020118

UniGene: Mm.1791